The origins of SARS-CoV-2: A critical review

Edward C. Holmes; Stephen A. Goldstein; Angela L. Rasmussen; David L. Robertson; Alexander Crits-Christoph; Joel O. Wertheim; Simon J. Anthony; Wendy S. Barclay; Maciej F. Boni; Peter C. Doherty; Jeremy Farrar; Jemma L. Geoghegan; Xiaowei Jiang; Julian L. Leibowitz; Stuart J. D. Neil; Tim Skern; Susan R. Weiss; Michael Worobey; Kristian G. Andersen; Robert F. Garry; Andrew Rambaut

doi:10.1016/j.cell.2021.08.017

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The origins of SARS-CoV-2: A critical review

Journal article

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The origins of SARS-CoV-2: A critical review

Edward C. Holmes, Stephen A. Goldstein, Angela L. Rasmussen, David L. Robertson, Alexander Crits-Christoph, Joel O. Wertheim, Simon J. Anthony, Wendy S. Barclay, Maciej F. Boni, Peter C. Doherty, …

Cell, Vol.184(19), pp.4848-4856

16/09/2021

DOI: https://doi.org/10.1016/j.cell.2021.08.017

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https://hdl.handle.net/10523/22141

Abstract

Biochemistry & Molecular Biology

Cell Biology

Life Sciences & Biomedicine

Science & Technology

Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus in December 2019 in Wuhan, China, there has been intense interest in understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the human population. Recent debate has coalesced around two competing ideas: a "laboratory escape" scenario and zoonotic emergence. Here, we critically review the current scientific evidence that may help clarify the origin of SARS-CoV-2.

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Record Identifier: 9926495083301891
Title: The origins of SARS-CoV-2: A critical review
Creators: Edward C. Holmes
Stephen A. Goldstein
Angela L. Rasmussen
David L. Robertson
Alexander Crits-Christoph
Joel O. Wertheim
Simon J. Anthony
Wendy S. Barclay
Maciej F. Boni
Peter C. Doherty
Jeremy Farrar
Jemma L. Geoghegan
Xiaowei Jiang
Julian L. Leibowitz
Stuart J. D. Neil
Tim Skern
Susan R. Weiss
Michael Worobey
Kristian G. Andersen
Robert F. Garry
Andrew Rambaut
Publication Details: Cell, Vol.184(19), pp.4848-4856
Academic Unit: Microbiology and Immunology
Publisher: Elsevier
Grant note: 206298/Z/17/Z-ARTIC / Wellcome Trust BB/S008292 / BBSRC; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) 2029949 / Direct For Biological Sciences; Div Of Biological Infrastructure; National Science Foundation (NSF); NSF - Directorate for Biological Sciences (BIO) 725422-ReservoirDOCS / European Research Council; European Research Council (ERC) MC_UU_12014/12; 220977/Z/20/Z / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) INV004212 / Bill andMelinda Gates Foundation; Bill & Melinda Gates Foundation INV-005517 / Bill and Melinda Gates Foundation; Bill & Melinda Gates Foundation Ministry of Agriculture; Gida Tarim Ve Hayvancilik Bakanligi INTU1901; ESEP1904; RIA2019LV-3053 / Coalition for Epidemic Preparedness Innovations Penn Center for Research on Coronaviruses and Other Emerging Pathogens Government of Saskatchewan through Innovation Saskatchewan R01AI132223; R01AI132244; U19AI135995; U54HG007480; U19AI142790; U01AI151812 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA WT098049AIA / Wellcome Trust Senior Fellowship; Wellcome Trust Canada Foundation for Innovation-Major Science Initiatives Fund; Canada Foundation for Innovation 2029949 / NSF; National Science Foundation (NSF) FL170100022 / ARC Australian Laureate Fellowship; Australian Research Council INV-005517; RDF-20-UOO-007 / Bill and Melinda Gates Foundation; Bill & Melinda Gates Foundation Arizona Board of Regents P 28183 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC)
Date published ; e-published: 16/09/2021
Language: English
Resource Type ; Subtype: Journal article