Abstract
• First reported synthesis of clavatadine C.
• 5 steps with 38% overall yield.
• Discovered to have moderate anti-cancer activity.
The first synthesis of clavatadine C was achieved in 5 steps and an overall yield of 38%. The key step in the synthesis features a highly efficient one-pot dibromination and oxidative spirocyclization sequence to forge the spiro-2,6-dibromocyclohexadienone isoxazoline scaffold. Clavatadine C was found to possess moderate cytotoxicity against both breast and colon cancer cell lines.