Abstract
The promise of genomics-focused neuroscience to improve health outcomes for Indigenous Peoples depends on ensuring more equitable data relationships though culturally appropriate data governance and the technical infrastructure to enable its implementation. Although ethical frameworks and legal policy mechanisms affirm Indigenous rights, there is a persistent gap in translating these commitments into practice. Here we discuss how embedding Indigenous data governance across research infrastructures and data ecosystems is needed to strengthen the field’s capacity to deliver beneficial outcomes for all.