Abstract
► TFF1 enhances prostate carcinoma cell migration and invasion. ► TFF1 reduces expression of E-CADHERIN in prostate carcinoma cells and E-CADHERIN rescue abrogates TFF1 stimulated migration. ► TFF1 enhances prostate carcinoma cell metastasis in a xenograft model. ► Inhibition of TFF1 using specific inhibitory antibodies or specific RNAi reduces prostate carcinoma cell invasion.
Metastasis is the primary mediator of prostate cancer (PCA) lethality and poses a significant clinical obstacle. The identification of factors involved in the metastasis of PCA is imperative. We demonstrate herein that trefoil factor 1 (TFF1) promotes PCA cell migration and invasion in vitro and metastasis in vivo. The capacity of TFF1 to enhance cell migration/invasion is mediated by transcriptional repression of E-CADHERIN. Consideration of targeted inhibition of TFF1 to prevent metastasis of prostate carcinoma is warranted.