Trends in the ulcerative colitis to Crohn’s disease incidence ratio are distinct between epidemiologic stages of Inflammatory bowel disease

Joseph W Windsor; Stephanie Coward; Lindsay Hracs; Joyce W Y Mak; Rupa Banerjee; Paulo G Kotze; Richard Gearry; Siew C Ng; Gilaad G Kaplan; Global IBD Visualization of Epidemiology Studies in the 21s,t Century (GIVES-21) Research Group

doi:10.14309/ajg.0000000000003868

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Trends in the ulcerative colitis to Crohn’s disease incidence ratio are distinct between epidemiologic stages of Inflammatory bowel disease

Journal article

Peer reviewed

Trends in the ulcerative colitis to Crohn’s disease incidence ratio are distinct between epidemiologic stages of Inflammatory bowel disease

Joseph W Windsor, Stephanie Coward, Lindsay Hracs, Joyce W Y Mak, Rupa Banerjee, Paulo G Kotze, Richard Gearry, Siew C Ng, Gilaad G Kaplan and Global IBD Visualization of Epidemiology Studies in the 21s,t Century (GIVES-21) Research Group

The American journal of gastroenterology

24/11/2025

DOI: https://doi.org/10.14309/ajg.0000000000003868

Handle:

https://hdl.handle.net/10523/49029

Abstract

Inflammatory bowel disease

ulcerative colitis

epidemiologic transition

incidence ratio

Crohn’s disease

Introduction: The ulcerative colitis (UC) to Crohn's disease (CD) incidence ratio varies across geography and time. Methods: We analyzed UC:CD incidence ratios across three epidemiologic stages using generalized additive models for location, shape, and scale and pooled average annual percent changes (AAPCs) by meta-analysis. Results: Ratios significantly decreased: median 3.62 in stage 1, 1.82 in stage 2, 1.55 in stage 3; the incidence ratio stabilized in stage 3 (AAPC: -0.12; 95%CI: -0.66, 0.42). Discussion: Decreasing UC:CD incidence ratios signal a rising burden of CD, underscoring the need to anticipate greater healthcare demand, including higher treatment costs and higher prevalence of complications.

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Record Identifier: 9926795283501891
Title: Trends in the ulcerative colitis to Crohn’s disease incidence ratio are distinct between epidemiologic stages of Inflammatory bowel disease
Creators: Joseph W Windsor
Stephanie Coward
Lindsay Hracs
Joyce W Y Mak
Rupa Banerjee
Paulo G Kotze
Richard Gearry
Siew C Ng
Gilaad G Kaplan
Global IBD Visualization of Epidemiology Studies in the 21s,t Century (GIVES-21) Research Group
Publication Details: The American journal of gastroenterology
Academic Unit: Medicine (UOC)
Publisher: Wolters Kluwer
Date published ; e-published: 24/11/2025
Comment: The published version is not available in full-text in OUR Archive. Where available, a link to the published version is provided (check the DOI and/or the Files and links section). The full-text item may be open access on the publisher's website. An earlier version of the work (such as authors' accepted manuscript following peer-review or unreviewed preprint/author's original version) may be available in the Files and links section of this record. Alternatively, readers may have subscription access to the full-text from the publisher.
Language: English
Resource Type ; Subtype: Journal article

Trends in the ulcerative colitis to Crohn’s disease incidence ratio are distinct between epidemiologic stages of Inflammatory bowel disease

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