Ubiquitin Variant Inhibitors Meet the Deubiquitinase USP15

Adam J. Middleton; Catherine L. Day

doi:10.1016/j.str.2019.03.011

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Ubiquitin Variant Inhibitors Meet the Deubiquitinase USP15

Journal article

Open access

Peer reviewed

Ubiquitin Variant Inhibitors Meet the Deubiquitinase USP15

Adam J. Middleton and Catherine L. Day

Structure (London), Vol.27(4), pp.564-565

02/04/2019

DOI: https://doi.org/10.1016/j.str.2019.03.011

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https://hdl.handle.net/10523/36498

Abstract

Biochemistry & Molecular Biology

Biophysics

Cell Biology

Life Sciences & Biomedicine

Science & Technology

Deubiquitinases (DUBs) are important regulators of cellular function and selective inhibitors are required to reveal their biological role and therapeutic potential. In this issue of Structure, Teyra et al. (2019) report the development of DUB USP15 inhibitors that provide a starting point for the analysis of USP15 function.

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Record Identifier: 9926529320401891
Title: Ubiquitin Variant Inhibitors Meet the Deubiquitinase USP15
Creators: Adam J. Middleton
Catherine L. Day
Publication Details: Structure (London), Vol.27(4), pp.564-565
Academic Unit: Biochemistry
Publisher: Elsevier
Grant note: Marsden Fund; Royal Society of New Zealand; Marsden Fund (NZ) Health Research Council of New Zealand
Date published ; e-published: 02/04/2019
Language: English
Resource Type ; Subtype: Journal article