BET inhibition prevents aberrant RUNX1 and ERG transcription in STAG2 mutant leukaemia cells

Jisha Antony; Gregory Gimenez; Terry Taylor; Umaima Khatoon; Robert Day; Ian M Morison; Julia A Horsfield

doi:10.1093/jmcb/mjz114

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BET inhibition prevents aberrant RUNX1 and ERG transcription in STAG2 mutant leukaemia cells

Letter/Communication

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BET inhibition prevents aberrant RUNX1 and ERG transcription in STAG2 mutant leukaemia cells

Jisha Antony, Gregory Gimenez, Terry Taylor, Umaima Khatoon, Robert Day, Ian M Morison and Julia A Horsfield

Journal of molecular cell biology, Vol.12(5), pp.397-399

11/06/2020

DOI: https://doi.org/10.1093/jmcb/mjz114

Handle:

https://hdl.handle.net/10523/36720

Appears in Chromosome Structure and Development Group (CSDG)

Abstract

Letter to the Editor

CRISPR-Cas9

ERG

RUNX1

STAG2

chromatin

cohesin

enhancer

inducible

megakaryocyte

Cohesin is a multiprotein complex that not only is essential for cell division but also has key roles in genome organization that underpin its gene regulatory function.

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Record Identifier: 9926529240101891
Title: BET inhibition prevents aberrant RUNX1 and ERG transcription in STAG2 mutant leukaemia cells
Creators: Jisha Antony
Gregory Gimenez
Terry Taylor
Umaima Khatoon
Robert Day
Ian M Morison
Julia A Horsfield
Publication Details: Journal of molecular cell biology, Vol.12(5), pp.397-399
Academic Unit: Pathology and Molecular Medicine (DSM); Biochemistry
Publisher: Oxford University Press
Grant note: This work was supported by Health Research Council of NZ award 15/229 to J.A.H. and a Cancer Research Trust of NZ award to J.A. and J.A.H.
Date published ; e-published: 11/06/2020
Copyright: Copyright © The Author(s) 2020. This work was first published in Journal of Molecular Cell Biology (Oxford University Press). This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://www.creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, provided that the original work is properly attributed to the creator(s) and the source, a link to the Creative Commons license is provided, and any changes made are indicated.
Language: English
Resource Type ; Subtype: Letter/Communication