Utilizing urinary single-cell RNA sequencing to explore the pathogenesis of diabetic kidney disease progression

Henry H L Wu; Long The Nguyen; Naveen Kumar Parthiban; Joey Lai; David Zheng; Chia-Ling Chan; Robert J Walker; Carol A Pollock; Sonia Saad

doi:10.1093/ckj/sfag230

Utilizing urinary single-cell RNA sequencing to explore the pathogenesis of diabetic kidney disease progression

Henry H L Wu, Long The Nguyen, Naveen Kumar Parthiban, Joey Lai, David Zheng, Chia-Ling Chan, Robert J Walker, Carol A Pollock Sonia Saad

Clinical kidney journal, Vol.19(8), sfag230

10/07/2026

: https://doi.org/10.1093/ckj/sfag230

https://hdl.handle.net/10523/51905

Letter to the Editor

diabetic kidney disease (DKD)

single-cell ribonucleic acid sequencing (scRNAseq)

biomarkers

prognostication

There is now recognized potential in utilizing scRNAseq as a prognostic biomarker in early DKD, with urinary exfoliated kidney cells being previously applied as non-invasive biomarkers for DKD prognostication. Whilst the pathogenesis of DKD was previously explored using serum scRNAseq, few studies have done so currently based on urinary scRNAseq. There were no published studies which considered the utility of urinary scRNAseq to determine the pathogenesis of DKD progression over time. Our group conducted a pilot study to explore on this.

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https://doi.org/10.1093/ckj/sfag230

Published (Version of record)

: 9926894587301891
: Utilizing urinary single-cell RNA sequencing to explore the pathogenesis of diabetic kidney disease progression
: Henry H L Wu
Long The Nguyen
Naveen Kumar Parthiban
Joey Lai
David Zheng
Chia-Ling Chan
Robert J Walker
Carol A Pollock
Sonia Saad
: Medicine (DSM)
: Clinical kidney journal, Vol.19(8), sfag230
: Oxford University Press
: 10/07/2026
: Copyright © The Author(s) 2026. This work was first published in Clinical Kidney Journal (Oxford University Press). This is an open access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://www.creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, provided that the original work is properly attributed to the creator(s) and the source, a link to the Creative Commons license is provided, and any changes made are indicated.
: English
: Letter/Communication