Abstract
The evidence for harm to human health caused by plastic has grown in the last five years, notably from chemical additives in plastics and plastic particles themselves. This evidence strengthens the case for urgent action to prevent further plastic pollution, remediate environments containing plastic, reduce our interactions with plastics in our day-today lives, and minimise exposure to plastic particles i where possible. While individual actions are helpful, we need systematic change at the local, national, and global levels to achieve a comprehensive response to the environmental and health threats from plastics.