Physiology and pharmacology of the brushtail possum gastrointestinal tract: Relationship to the human gastrointestinal tract
McDowell, Arlene; McLeod, Bernie
Oral formulations are typically based on studies from eutherian animal models. This review introduces information relating to oral formulations for a marsupial species, the Australian brushtail possum (Trichosurus vulpecula) that have arisen from research into new methods for controlling this species, a major vertebrate pest in New Zealand. Morphologically, the gastrointestinal tract of the possums is similar to that of hindgut fermenting eutherian species, but there are some striking differences in function. Limited data suggests that the pharmacokinetics and bioavailability of administered drugs is similar to that in eutherian species, but there is some evidence that possums may have specific mechanisms for handling the intake of plant toxins and xenobiotics. The development of oral formulations for a free-ranging pest species presents several challenges above those encountered in the development of therapeutic formulations for humans and domestic animals. Use of a marsupial animal model may lead to new strategies for oral formulations in humans.
Rights Statement: This version in OUR Archive is the author’s manuscript accepted for publication after peer-review. The published version is: McDowell A, McLeod BJ. Physiology and pharmacology of the brushtail possum gastrointestinal tract: relationship to the human gastrointestinal tract. Adv Drug Deliv Rev. 2007 Sep 30;59(11):1121-32. doi: 10.1016/j.addr.2007.06.012. This OUR Archive version is licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International https://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Oral delivery; Marsupial; caecum; LHRH; Gastrointestinal pH; transit time; Trichosurus vulpecula
Research Type: Journal Article
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