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dc.contributor.advisorButler, Anthony
dc.contributor.advisorRaja, Aamir
dc.contributor.advisorGieseg, Steven
dc.contributor.authorDahal, Shishir
dc.date.available2021-10-06T00:18:55Z
dc.date.copyright2021
dc.identifier.citationDahal, S. (2021). Characterization of atherosclerotic plaque with MARS imaging (Thesis, Doctor of Philosophy). University of Otago. Retrieved from http://hdl.handle.net/10523/12319en
dc.identifier.urihttp://hdl.handle.net/10523/12319
dc.description.abstractThis thesis illustrates the ability of MARS photon counting spectral CT (SPCCT) to identify and quantify intrinsic features of atherosclerotic plaque responsible for its rupture. Atherosclerosis is a disease in which plaque build-up in the arterial wall that can rupture and cause luminal occlusion leading to vascular insufficiency to the end organ. It is an ongoing degenerative process with grave consequences; necessitating timely identification of rupture prone plaque for risk stratification and mitigation of the disease. An estimated eight carotid endarterectomies are required to prevent one stroke in symptomatic patients with severe carotid artery stenosis whereas 30 carotid endarterectomies are required to prevent one stroke in asymptomatic patients. This limited ability to select patients at risk of stroke and the numbers need to treat with invasive and complex surgery that has an intrinsic risk of iatrogenic stroke has compelled to find more efficient imaging technology. Works presented in this thesis illustrate an effectiveness of MARS SPCCT in characterising different morphological components of atheroma, essential parameters to distinguish rupture prone plaque from stable one. Intrinsic characteristics of plaques were quantitatively and qualitatively evaluated in MARS images and compared with histopathological findings. Individual experiments explained in this thesis were designed to address research hypotheses while addressing possible sources of biases. Data analysis were done with suitable statistical tests. This research demonstrates the effectiveness of MARS SPCCT in atherosclerotic plaque imaging. It also shows the traslational potential of MARS SPCCT for clinical application helping clinician to choose appropriate protocol thereby improving patient care and treatment outcomes.en_NZ
dc.format.mimetypeapplication/pdf
dc.language.isoenen_NZ
dc.publisherUniversity of Otago
dc.rightsAll items in OUR Archive are provided for private study and research purposes and are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectSpectral photon counting CTen_NZ
dc.subjectAtherosclerotic plaqueen_NZ
dc.subjectBiomarkers of rupture prone plaquesen_NZ
dc.subjectMARS scanneren_NZ
dc.subjectLipid rich necrotic coreen_NZ
dc.subjectFibrous capen_NZ
dc.subjectIntraplaque hemorrhageen_NZ
dc.subjectIntraplaque calcificationen_NZ
dc.subjectStrokeen_NZ
dc.titleCharacterization of atherosclerotic plaque with MARS imagingen_NZ
dc.typeThesis
dc.date.updated2021-10-05T03:59:36Z
dc.language.rfc3066en
thesis.degree.disciplineDepartment of Radiology, UOCen_NZ
thesis.degree.nameDoctor of Philosophyen_NZ
thesis.degree.grantorUniversity of Otago
thesis.degree.levelDoctoral
otago.openaccessOpenen_NZ
otago.evidence.presentYes
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