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dc.contributor.authorKremer, Lisa
dc.contributor.authorReith, David
dc.contributor.authorMedlicott, Natalie J
dc.contributor.authorBroadbent, Roland
dc.date.available2021-12-22T00:41:15Z
dc.date.copyright2019-05
dc.identifier.citationKremer LJ, Reith DM, Medlicott N, et alSystematic review of mydriatics used for screening of retinopathy in premature infantsBMJ Paediatrics Open 2019;3:e000448. doi: 10.1136/bmjpo-2019-000448en_NZ
dc.identifier.urihttp://hdl.handle.net/10523/12630
dc.description.abstractIntroduction Routine retinopathy of prematurity eye examinations are an important part of neonatal care, and mydriatic medicines are essential in dilating the pupil for the eye examination. There are concerns about the level of evidence for efficacy and safety of these mydriatic medicines. Objective This review evaluates both efficacy and safety evidence of mydriatics used during the retinopathy of prematurity eye examination. Method Systematic literature review. Results There is limited evidence guiding clinical practice for safety and efficacy of mydriatics. The majority of publications are underpowered and with an unclear to high level of bias. There are a wide variety of mydriatic regimens evaluated for efficacy and safety, and multiple regimens are associated with case reports. Conclusions Current international guideline seems unnecessarily high, especially when the reviewed literature suggest that lower doses are effective, albiet from underpowered studies. The lowest effective combination regimen appears to be phenylephrine 1% and cyclopentolate 0.2% (1 drop). Microdrop administration of this regimen would further increase the safety profile, however, efficacy needs to be assessed.en_NZ
dc.format.mimetypeapplication/pdf
dc.publisherBritish Medical Journalen_NZ
dc.relation.ispartofBritish Medical Journal Paediatrics Openen_NZ
dc.subjectphenylephrineen_NZ
dc.subjectcyclopentolateen_NZ
dc.subjecttropicamideen_NZ
dc.subjectmydriasisen_NZ
dc.subjectpupil dilationen_NZ
dc.subjectadverse effectsen_NZ
dc.subjecteye dropsen_NZ
dc.subjectadministration and dosageen_NZ
dc.subjectophthalmic solutionen_NZ
dc.subjectpupilen_NZ
dc.titleSystematic review of mydriatics used for screening of retinopathy in premature infantsen_NZ
dc.typeJournal Articleen_NZ
dc.date.updated2021-12-21T00:27:07Z
otago.schoolSchool of Pharmacyen_NZ
dc.identifier.doi10.1136/bmjpo-2019-000448en_NZ
otago.openaccessOpenen_NZ
dc.rights.statement© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.en_NZ
dc.description.refereedPeer Revieweden_NZ
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