Abstract
Objective: This study sought to determine the relationship between levels of the inflammatory marker, C-reactive protein (CRP), cardiovascular risk factors and oral contraceptive use in young adults. Design: Cross-sectional study of a community cohort. Subjects: 822 men and women aged 26 years. Measurements: CRP, body mass index (BMI), blood pressure, lipid and lipoprotein levels, smoking status, socioeconomic status, health status, and hormonal contraceptive use in women. Results: Multiple regression analysis showed obesity was independently related to CRP with an increase in ratio CRP of 1.03 (95% CI; 1.01, 1.05) for men and 1.07 (1.05, 1.09) for women associated with a 1 kg/m2 increase in BMI. In women combined oral contraceptive use was associated with a ratio change in CRP of 1.52 (1.27, 1.82) compared with non users. Other independent determinants of CRP in men and women were apolipoprotein B level, systolic blood pressure and apolipoprotein A in men. Univariate analysis showed the relationship between CRP and BMI, systolic blood pressure and apolipoprotein B was significantly stronger in women than men. Conclusion: These findings suggest obesity is associated with inflammation independent of other cardiovascular risk factors which may contribute to an increased risk for cardiovascular disease in men and women. Elevated CRP related to combined oral contraceptive use may influence the rate of cardiovascular events in young women.