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dc.contributor.advisorMoratti, Stephen Carl
dc.contributor.advisorHanton, Lyall
dc.contributor.authorKirchhoefer, Cathrin
dc.date.available2011-08-08T20:51:28Z
dc.date.copyright2011
dc.identifier.citationKirchhoefer, C. (2011). Chitosan / Dextran Based Hydrogels as Drug Delivery Systems (Thesis, Master of Science). University of Otago. Retrieved from http://hdl.handle.net/10523/1825en
dc.identifier.urihttp://hdl.handle.net/10523/1825
dc.description.abstractControlled drug release enhances the safety, efficiency and reliability of drug administration. Regulation of the release rate results in a reduced frequency of the administration and supports the patient´s comfort. In the recent years, hydrogels have experienced an increase interest with respect to their potential in biomedical applications. At the same time the outstanding characteristics of polysaccharides have attracted attention. Combining both, our group has developed a chitosan/dextran based hydrogel for surgical use. Promising results have been obtained from sheep studies and human trials using the hydrogel as wound dressing in endoscopic sinus surgery. Considering the requirements after surgery, the idea arose to use the gel at the same time as a controlled delivery system. The aim of this research programme was to investigate the ability of the hydrogel in sustained release applying three model drugs. An anti-inflammatory, an anti-microbial drug as well as a painkiller were chosen for this study taking the healing process and the well-being of patients into account. Different characteristics of the compounds and the hydrogel were also determined.
dc.language.isoen
dc.publisherUniversity of Otago
dc.rightsAll items in OUR Archive are provided for private study and research purposes and are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectPolymer
dc.subjectDrug Delivery
dc.subjectGel
dc.subjectChitosan
dc.titleChitosan / Dextran Based Hydrogels as Drug Delivery Systems
dc.typeThesis
dc.date.updated2011-08-03T23:51:37Z
thesis.degree.disciplineChemistry
thesis.degree.disciplineChemistryen_NZ
thesis.degree.nameMaster of Science
thesis.degree.grantorUniversity of Otago
thesis.degree.levelMasters Theses
otago.interloannoen_NZ
otago.openaccessAbstract Only
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