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School of Pharmacy
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(Thesis, Doctor of Philosophy, 2016)Psychotropic medicines are defined by World Health Organisation Collaborating Centre for Drug statistics Methodology as psycholeptics (central nervous system calming effect) and psychoanaleptics (central nervous system ...
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(Thesis, Doctor of Philosophy, 2016)Introduction After birth rapid metabolic adaptation is required to establish glucose homeostasis.Preterm birth disrupts normal timing of this physiological adaptation putting premature neonates at risk of hypo- and ... -
(Thesis, Doctor of Philosophy, 2016)Background: access to healthcare services and medicines is a major problem in low-income countries. Despite a long history of modern healthcare practice, receiving international aid for health and the adoption of a free ... -
(Thesis, Doctor of Philosophy, 2016)The immune responses generated against tumour cells are not always capable of controlling tumour growth. Immunotherapeutic vaccines utilise the immune system’s ability to detect and destroy tumour cells and are a promising ... -
(Thesis, Doctor of Philosophy, 2016)Context: On a conceptual level, triggering drug release from liposomes using ultrasound (US) involves the liberation of encapsulated drug by acoustic energy at a predetermined site and time. Depending upon the parameters ...
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(Thesis, Master of Health Sciences, 2016)Introduction: Toxicological analysis of post-mortem tissue can confirm whether drugs were implicated in death. Alternative toxicological specimens, such as blowfly larvae (Lucilia sericata) are used when traditional tissue ...
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(Thesis, Master of Medical Science, 2016)Introduction: Intravenous gentamicin is frequently prescribed for the empiric treatment of early-onset sepsis in premature neonates1. The effective delivery of gentamicin may be influenced by infusion rate and flush volume2. ... -
(Thesis, Doctor of Philosophy, 2016)Allergic or atopic conditions can collectively affect more than 25% of the population, and current treatments are limited by their lack of disease modifying effects, which emphasises the immense benefits that could be ...
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(Thesis, Doctor of Philosophy, 2016)Medicines with anticholinergic activity are widely prescribed for the older population aged ≥ 65 years for various medical conditions. A current estimate is that one-third to more than one-half of commonly prescribed ...
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(Thesis, Doctor of Philosophy, 2016)Rheumatoid arthritis (RA) is a common inflammatory disease that affects between 0.5% and 1% of adults in developed countries. It is a chronic and progressive disorder that is characterised by systemic inflammation in joints, ...
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(Thesis, Doctor of Philosophy, 2015)Pharmacometric methods have seen increased application in clinical pharmacology in recent years. These methods are applied from the early stages of drug discovery to clinical practice. Pharmacometrics combines knowledge ...
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(Thesis, Doctor of Philosophy, 2015)Proteins are being used as therapeutic active components by the pharmaceutical industry. However, protein drugs may suffer physical and chemical degradation as results of protein purification and formulation. The physical ... -
(Thesis, Doctor of Philosophy, 2015)Drug therapy is an important component of the treatment and prevention of diseases. A drug is administered to achieve a treatment target so it is important to quantify the drug dose and dosing regimen prior to administration ... -
(Thesis, Doctor of Philosophy, 2015)It is known that increased adherence to appropriately prescribed drugs is associated with better therapeutic outcomes and contributes to lower mortality. Adherence is described by three processes, namely initiation, ... -
(Thesis, Doctor of Philosophy, 2015)Formulating drugs in the amorphous form is an attractive and promising strategy to overcome the poorly water soluble challenge commonly encountered in the newly discovered drug. The active research in the investigation of ...
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(Thesis, Doctor of Philosophy, 2015)Introduction: Polymeric nanoparticles can be used as carriers to improve oral bioavailability of therapeutic peptides or proteins. These polymeric carriers can be formulated with cell-penetrating peptides such as ... -
(Thesis, Doctor of Philosophy, 2015)Statement of the problem. Protein drugs are important therapeutic agents and lipids can be used to prepare protein dosage forms. However, proteins may degrade during the formulation processing leading to changes in ...
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(Thesis, Doctor of Philosophy, 2014)Melanoma is the most serious form of skin cancer, with New Zealand having the world’s highest incidence rates. It is characterised by an aggressive clinical behaviour, associated with metastasis to distant organs and poor ...
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(Thesis, Doctor of Philosophy, 2007)Background: In September 2001, in addition to their existing management of primary care pharmaceutical expenditure, PHARMAC, the New Zealand government's Pharmaceutical Management Agency, was authorized to manage pharmaceutical ... -
(Thesis, Doctor of Philosophy, 2014)Infectious diseases are a worldwide health problem. The lack of effective and affordable medications for infections such as AIDS and systemic fungal infections poses a serious concern in modern medicine. Furthermore, most ...
