School of Pharmacy
Recent Deposits
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Development of Fluorescent Ligands for CB2 receptor
CB2 receptor plays an important role in inflammation and has been implicated in the pathologies of several diseases, including neurodegenerative disorders, cancer, and atherosclerosis. However, there is a lack of understanding ... -
The Communication of Science through Crime Fiction
Background: Science can be communicated informally through fictional media. Crime fiction in print media has contained elements of forensic science since the first detective stories, for example, Sherlock Holmes. Modern ... -
Deprescribing in Older New Zealanders
Polypharmacy, the prescription of five or more medicines, is an emerging worldwide health concern. When older people are prescribed five or more medicines, they are susceptible to a wide variety of negative health consequences, ... -
The dose individualisation of oral anticoagulants
Oral anticoagulants are used to treat and prevent blood clots. All anticoagulants carry the risk of bleeding if the systemic exposure is too high, while inadequate exposure will increase the risk of thrombosis. Therefore, ... -
ISCOMs and related colloidal particles prepared by the lipid film hydration method for antigen delivery
Purposes: The aims of this thesis were to physicochemically investigate the formation of ISCOM matrices and other types of colloidal particles formed in aqueous dispersion as a function of different mass ratios of Quil A, ... -
The introduction of an advanced role for pharmacy technicians into the New Zealand pharmacy setting
The roles of pharmacists and pharmacy technicians are changing, both within New Zealand and internationally. The move of New Zealand pharmacists into the more clinically focused roles of their overseas colleagues has however ... -
What patients pay for medicines: a comparison of six countries
Introduction Pharmaceutical expenditure is rising in high-income countries. Some countries choose to pass some of these costs on to patients through various cost-sharing strategies. In many countries, patients pay an ... -
I can see clearly now: Survey results from neonatal staff on mydriatic use in retinopathy or prematurity screening
Aims: Very preterm infants require mydriatic eye drops in preparation for retinopathy of prematurity examination. Mydriatic dosing needs to provide adequate pupil dilation for the examination and yet, avoid adverse ... -
Lack of evidence and consequential harm caused by mydriatic regimens used in retinopathy of prematurity screening.
Approximately 3,500 infants in New Zealand and Australia are screened annually for retinopathy of prematurity (ROP). To view the retina and diagnose ROP, adequate pupil dilation with mydriatic medicines is required. ... -
Developing Novel Chlamydia-Targeted Protease Inhibitors
Chlamydia trachomatis is an obligate intracellular human parasite responsible for the most common sexually transmitted bacterial infection world-wide. The largely asymptomatic infection frequently results in complications ... -
Pharmacoepidemiological approaches examining preventive medicines and multimorbidity in older people
Prescribing medicines for older people, aged 65 years and older, with multimorbidity is challenging. Preventive medicines are often prescribed in older people to prevent diseases or to confer health benefits. However, it ... -
Maternity Outcomes and Access following Regulatory Changes for Isotretinoin Prescribing in New Zealand
Aims: Oral isotretinoin is an effective treatment for severe acne that is teratogenic. On 1 March 2009 funded access to oral isotretinoin in New Zealand was extended from dermatologist-only to also include prescriptions ... -
Psychotropic medicine utilisation in older people: A pharmacoepidemiological approach
Psychotropic medicines are defined by World Health Organisation Collaborating Centre for Drug statistics Methodology as psycholeptics (central nervous system calming effect) and psychoanaleptics (central nervous system ... -
Factors affecting glucose homeostasis in premature neonates
Introduction After birth rapid metabolic adaptation is required to establish glucose homeostasis.Preterm birth disrupts normal timing of this physiological adaptation putting premature neonates at risk of hypo- and ... -
Medicines, society and the health system: a case study of access to and use of medicines in the Annapurna region of Western Nepal
Background: access to healthcare services and medicines is a major problem in low-income countries. Despite a long history of modern healthcare practice, receiving international aid for health and the adoption of a free ... -
Bio-conjugate Approaches for Improved Targeted Toll-like receptor based Immune Adjuvant Vaccines
The immune responses generated against tumour cells are not always capable of controlling tumour growth. Immunotherapeutic vaccines utilise the immune system’s ability to detect and destroy tumour cells and are a promising ... -
Ultrasound Sensitive Liposomes
Context: On a conceptual level, triggering drug release from liposomes using ultrasound (US) involves the liberation of encapsulated drug by acoustic energy at a predetermined site and time. Depending upon the parameters ... -
Drug metabolism in Lucilia sericata larvae
Introduction: Toxicological analysis of post-mortem tissue can confirm whether drugs were implicated in death. Alternative toxicological specimens, such as blowfly larvae (Lucilia sericata) are used when traditional tissue ... -
Variability in neonatal gentamicin administration influencing drug delivery kinetics
Introduction: Intravenous gentamicin is frequently prescribed for the empiric treatment of early-onset sepsis in premature neonates1. The effective delivery of gentamicin may be influenced by infusion rate and flush volume2. ... -
Evaluation of oral particulate formulations containing α-galactosylceramide for the treatment of allergy
Allergic or atopic conditions can collectively affect more than 25% of the population, and current treatments are limited by their lack of disease modifying effects, which emphasises the immense benefits that could be ...