School of Pharmacy
Recent Deposits
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Pharmacometric modelling of haemodynamics in humans
Current pharmacokinetic-pharmacodynamic models describing changes to the haemodynamic system often do not include necessary feedback mechanisms. These models often provide an adequate empirical description of data but may ... -
The use of metformin in patients with renal impairment
Metformin, a biguanide, is widely accepted to be the preferred first-line oral antihyperglycaemic agent to manage type 2 diabetes. There is considerable concern that patients receiving metformin therapy may be at an increased ... -
Evaluation of intranasal particulate strategies to enhance the delivery of anti-seizure therapeutics to the brain
Epilepsy is a common and serious neurological disorder to which a high proportion of patients continue to be considered “drug-resistant” despite the availability of a host of anti-seizure drugs. Investigation into new ... -
Dabigatran etexilate dosing and monitoring in Aotearoa New Zealand
Introduction Dabigatran etexilate is a direct thrombin inhibitor that has become widely used in New Zealand. It has been available and fully subsidised in New Zealand since July 2011. Of patients who receive oral ... -
Dose adjustment based on renal function
Patients with impaired kidney function are at risk of excessive drug exposure and toxicity when standard doses of renally cleared drugs are used. Dose adjustment to normalise drug exposure between patients may be required ... -
In vitro and in vivo studies on the binding and permeation of ketotifen and norketotifen atropisomers in the central nervous system
Ketotifen (K) is a first-generation antihistamine with antiinflammatory potency. It penetrates the blood-brain barrier (BBB) and causes a sedative side effect. Norketotifen (N) is an active metabolite of K. The S-atropisomer ... -
Cell-penetrating peptides for enhanced oral delivery of nanoformulations
Introduction: Oral drug delivery systems such as polymeric nanoparticles are used to improve therapies that utilize biomacromolecules like proteins and peptides. Surface modifications of polymeric nanoparticles play a ... -
Military Medicines: ANZAC Military Pharmacy, 1914-1918
Military pharmacy is a niche subset of the wider pharmacy profession. As a small component of the armed forces, the role encompasses unique military requirements beyond usual pharmacy practice. This thesis analyses the ... -
Application of pharmacometric methods to quantify functional selectivity
Interest has arisen in the ability of ligands to differentially regulate signalling pathways when coupled to a single receptor, a concept termed functional selectivity. The current approach used to quantify functional ... -
Understanding antiepileptic drug exposure in pregnancy: the consequences for mother and child
Background: Antiepileptic drugs (AEDs) are used to manage several neurological conditions and continued use throughout pregnancy is often necessary. AED use during pregnancy has been linked to elevated obstetric risk and ... -
Non-Lamellar Liquid Crystalline Nanoparticles for Targeted Delivery of Endogenous Lipids to the Brain
Purpose: Bioactive endogenous lipids such as N-acylethanolamines (NAEs) and alkylglycerols have shown therapeutic potential in various neurological diseases and targeted brain drug delivery, respectively. However, their ... -
Scaling of clearance by body size and composition
Dose scaling is a critical component of dose individualisation that helps ensure that the required amount of drug exposure is achieved in each and every patient. This is typically achieved by scaling the pharmacokinetic ... -
Slow dissolving inhalable dry powders for treatment of pulmonary tuberculosis
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis, which mainly affects the lungs. The current treatment by the oral or/and parenteral route of administration requires very high doses of the ... -
Understanding azathioprine metabolism using a systems pharmacology approach
Quantitative systems pharmacology (QSP) modelling, being an integral part of pharmacometrics, is attracting a great amount of attention in drug development and clinical therapy as QSP models are used to identify drug targets ... -
Adherence to oral hypoglycaemic medications and the impact on diabetic biomarkers and clinical outcomes
Introduction Improving adherence to appropriately prescribed medications enhances clinical outcomes. To our knowledge, there is scarce literature on the implementation and outcomes of an adherence support service when ... -
Preparation and evaluation of oral nanoformulations containing antioxidant rutin
Purpose Oxidants induce oxidative stress in the body playing an important role in the development of diseases such as cancer, arthritis, cardiovascular and neurological disease. Rutin - a strong antioxidant - can scavenge ... -
Understanding health-seeking behaviours of people in Indonesia; and developing, piloting, and evaluating a culturally appropriate intervention for people with diabetes
Indonesia is facing a dual burden of communicable and non-communicable diseases. Childhood-immunisation coverage is lower than most countries in Southeast Asia, with vaccine-preventable disease outbreaks frequently reported. ... -
Application of pharmacometric methods to understand warfarin dose response
Existing warfarin dosing methods do not accurately predict warfarin maintenance doses for patients in the lower or upper quartile of dose requirements. It was argued that this is related to the use of the international ... -
An exploration of the medicines information needs of general practitioners and the information support roles of pharmacists in New Zealand
Background The optimal use of medicines is a fundamental goal in health policy worldwide. Using medicines effectively and safely relies on a large and constantly increasing knowledge base. Despite living in an era of ... -
pH responsive nanoparticles as versatile carriers for cancer chemotherapy and vaccination
Cancer is one of the leading causes of mortality and morbidity in the Western world. The anguish caused by cancer is exacerbated by current chemotherapeutic treatments as severe adverse effects can be caused by off-target ...