School of Pharmacy
Recent Deposits
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Application of pharmacometric methods to understand warfarin dose response
Existing warfarin dosing methods do not accurately predict warfarin maintenance doses for patients in the lower or upper quartile of dose requirements. It was argued that this is related to the use of the international ... -
An exploration of the medicines information needs of general practitioners and the information support roles of pharmacists in New Zealand
Background The optimal use of medicines is a fundamental goal in health policy worldwide. Using medicines effectively and safely relies on a large and constantly increasing knowledge base. Despite living in an era of ... -
pH responsive nanoparticles as versatile carriers for cancer chemotherapy and vaccination
Cancer is one of the leading causes of mortality and morbidity in the Western world. The anguish caused by cancer is exacerbated by current chemotherapeutic treatments as severe adverse effects can be caused by off-target ... -
Development of fluorescent ligands for A1 adenosine receptor and cannabinoid receptors
Adenosine A1 receptor (A1AR), cannabinoid type 1 receptor (CB1R) and cannabinoid type 2 receptor (CB2R) are class A G protein-coupled receptors (GPCRs) and play important roles in human pathophysiological conditions such ... -
Surface modified cubosomes for drug delivery across the blood-brain barrier
The bottleneck in delivering drugs to the brain for treatment of diseases related to central nervous system (CNS), lies behind the presence of blood-brain barrier (BBB). This barrier prevents most of the large and a number ... -
Development and Applications of Stimuli-Responsive Drug Delivery Strategies
In this thesis, bioorthogonal chemistry was explored as a means of developing stimuli-responsive nanoparticles and hydrogels. It has been hypothesised that the use of stimuli-responsive drug delivery systems will improve ... -
Spray-dried powder particles for treating pulmonary tuberculosis
Background Tuberculosis (TB) is a major global health burden. Rapid emergence of drug-resistant TB has aggravated the current situation of global TB. High dose delivery of drugs to the lung using a dry powder inhaler (DPI) ... -
Formulation Strategies to Enhance Nose-to-Brain Delivery of Drugs
Delivery of drugs via the intranasal olfactory route is a non-invasive and practical method of bypassing the blood-brain barrier (BBB). However, targeted delivery and retention of drugs to the olfactory region is a significant ... -
Spectroscopic investigation and quantitation of polymorphism and crystallinity of pharmaceutical compounds
Spectroscopy is increasingly used to investigate and monitor the solid state forms of pharmaceutical materials and products. Spectroscopy's speed, non-destructive sampling, compatibility with fibre optics and safety also ... -
Towards a deeper understanding of the polymorphic conversion of carbamazepine in aqueous suspension
Polymorphism can influence every aspect of the properties of a solid including the shelf life, dissolution rate, solubility, formulation properties and processing properties of a solid drug. A deeper understanding of ... -
Data Collected about Intentional Self-poisoning in New Zealand Emergency Departments and the Implications of Data Limitations for Prevention Planning
Background Intentional self-poisoning (ISP; taking a purposeful overdose) results in significant morbidity and is a burden on population health. In order to reduce ISP by, for example, restricting inappropriate access to ... -
Clinical decision-making: An essential skill for 21st century pharmacy pratice
Clinical decision-making skills are recognized as a central component of professional competency but are underdeveloped in pharmacy compared to other health professions. There is an urgent need for a comprehensive understanding ... -
Development of Fluorescent Ligands for CB2 receptor
CB2 receptor plays an important role in inflammation and has been implicated in the pathologies of several diseases, including neurodegenerative disorders, cancer, and atherosclerosis. However, there is a lack of understanding ... -
The Communication of Science through Crime Fiction
Background: Science can be communicated informally through fictional media. Crime fiction in print media has contained elements of forensic science since the first detective stories, for example, Sherlock Holmes. Modern ... -
Deprescribing in Older New Zealanders
Polypharmacy, the prescription of five or more medicines, is an emerging worldwide health concern. When older people are prescribed five or more medicines, they are susceptible to a wide variety of negative health consequences, ... -
The dose individualisation of oral anticoagulants
Oral anticoagulants are used to treat and prevent blood clots. All anticoagulants carry the risk of bleeding if the systemic exposure is too high, while inadequate exposure will increase the risk of thrombosis. Therefore, ... -
ISCOMs and related colloidal particles prepared by the lipid film hydration method for antigen delivery
Purposes: The aims of this thesis were to physicochemically investigate the formation of ISCOM matrices and other types of colloidal particles formed in aqueous dispersion as a function of different mass ratios of Quil A, ... -
The introduction of an advanced role for pharmacy technicians into the New Zealand pharmacy setting
The roles of pharmacists and pharmacy technicians are changing, both within New Zealand and internationally. The move of New Zealand pharmacists into the more clinically focused roles of their overseas colleagues has however ... -
What patients pay for medicines: a comparison of six countries
Introduction Pharmaceutical expenditure is rising in high-income countries. Some countries choose to pass some of these costs on to patients through various cost-sharing strategies. In many countries, patients pay an ... -
I can see clearly now: Survey results from neonatal staff on mydriatic use in retinopathy or prematurity screening
Aims: Very preterm infants require mydriatic eye drops in preparation for retinopathy of prematurity examination. Mydriatic dosing needs to provide adequate pupil dilation for the examination and yet, avoid adverse ...