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Characterization of Peptide Polymer Interactions in Poly(alkylcyanoacrylate) Nanoparticles: A Mass Spectrometric Approach

Kafka, Alexandra; Kleffmann, Torsten; Rades, Thomas; McDowell, Arlene

Drug/polymer interactions occur during in situ polymerization of poly(alkylcyanoacrylate) (PACA) formulations. We have used MALDI ionization coupled tandem time-of-flight (TOF) mass spectrometry as an accurate method to ...

Release and bioactivity of PACA nanoparticles containing D-Lys6-GnRH for brushtail possum fertility control

Kafka, Alexandra; McLeod, Bernie; Rades, Thomas; McDowell, Arlene

Poly(ethylcyanoacrylate) (PECA) nanoparticles containing the chemical sterilitant D-Lys6-GnRH were prepared by an in situ interfacial polymerization technique. Their potential as a peroral delivery system for biocontrol ...