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Non-Lamellar Liquid Crystalline Nanoparticles for Targeted Delivery of Endogenous Lipids to the Brain
Purpose: Bioactive endogenous lipids such as N-acylethanolamines (NAEs) and alkylglycerols have shown therapeutic potential in various neurological diseases and targeted brain drug delivery, respectively. However, their ...
Understanding antiepileptic drug exposure in pregnancy: the consequences for mother and child
Background: Antiepileptic drugs (AEDs) are used to manage several neurological conditions and continued use throughout pregnancy is often necessary. AED use during pregnancy has been linked to elevated obstetric risk and ...
Application of pharmacometric methods to quantify functional selectivity
Interest has arisen in the ability of ligands to differentially regulate signalling pathways when coupled to a single receptor, a concept termed functional selectivity. The current approach used to quantify functional ...
Cell-penetrating peptides for enhanced oral delivery of nanoformulations
Introduction: Oral drug delivery systems such as polymeric nanoparticles are used to improve therapies that utilize biomacromolecules like proteins and peptides. Surface modifications of polymeric nanoparticles play a ...