Dunedin School of Medicine
Sub-communities within Dunedin School of Medicine
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Medicine Department [89]
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Pathology Department [72]
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Surgical Sciences [31]
Collections in Dunedin School of Medicine
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Kōhatu – Centre for Hauora Māori [2]
Kōhatu – Centre for Hauora Māori
Recent Deposits
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Improving pain assessment, management, and research in low-income countries: An example of Nepal
Pain is a global public health problem resulting from complex interactions of multiple biopsychosocial factors. Most published pain research comes from developed countries using samples from western countries; developing ... -
Examining the role of cohesin subunit Rad21 in malignancy and development
The cohesin complex is essential for cell survival, owing to its well-established roles in cell division, DNA repair and gene expression. Malignancy and developmental disorders termed the cohesinopathies can result when ... -
Mechanisms of DNA demethylation
While every cell in an organism is genetically identical, there are marked phenotypic differences between tissues and organs that are controlled by epigenetic modifications. These epigenetic modifications provide an important ... -
Public health organization in four rural districts in Western Samoa.
In the light of the modern world, the inhabitants of underdeveloped countries, of which Samoa in the strict sense of the word is one, of them, frequently in their lower level of knowledgeable resources, referred to foreign ... -
Constitutive PD-L1 expression in melanoma
Treatment of melanoma based on targeted therapy and immunotherapy has dramatically advanced over the past decade. Advances in targeted therapy have been based on inhibition of the MAPK pathway while for immunotherapy, ... -
Investigating the Influence of Metabolic Syndrome on Cancer Immunotherapy
Cancer is a significant cause of morbidity in New Zealand, with breast and colorectal cancers being amongst the most commonly diagnosed. Therapeutic research has moved into immunotherapies, harnessing the immune system to ... -
Modeling RECQL4 developmental syndromes in Xenopus laevis using CRISPR/Cas9
There are a number of human genetic conditions of abnormal skeletal development associated with disrupted DNA replication, with several linked to mutations in RECQL4. While several mouse models targeting Recql4 have been ... -
Rotavirus Specific Maternal Antibodies and Immune Response to RV3-BB Neonatal Rotavirus Vaccine in New Zealand
Background: Rotavirus specific maternal antibodies acquired passively via placental and/or breast milk may contribute to the reduced oral rotavirus vaccine efficacy observed in children in developing countries. This study ... -
Development of zebrafish models for leukaemia
Throughout development, numerous binary cell fate decisions are made where cells activate competing transcriptional networks and subsequently upregulate one network over others based on extrinsic cues. Cell fate decisions ... -
THE NEW ZEALAND UNDERGRADUATE OBSTETRICS AND GYNAECOLOGY CURRICULUM
Aims of New Zealand O&G curriculum collaboration To ensure and continue to improve quality and consistency of learning outcomes in Obstetrics and Gynaecology on a national basis To inform the Medical Council of New ... -
Advanced Meta-analysis in Surgical Research
The continuous development and refinement of techniques is a key attribute of the discipline of surgery. Robust evidence derived from randomised clinical trials and subsequent synthesis using meta-analysis methods is ... -
Identification of synthetic lethal compounds targeting cancers with cohesin mutations
The cohesin complex, comprising four core subunits, RAD21, SMC3, SMC1A, and STAG1/2, is important for the regulation of many biological processes, including sister chromatid cohesion, regulation of gene expression, chromatin ... -
Child Poverty Monitor 2019: Technical Report
Children in Aotearoa New Zealand should be supported to live lives in which there are resources available for them to thrive, where they are experiencing wellbeing and opportunities to work towards fulfilling their potential, ... -
Atherogenic Index In Plasma and Risk of Cardiovascular Events
As dyslipidaemia is a prominent CVD risk factor, improvements in its management are crucial, as dyslipidaemia (quantified by hypercholesterolemia and treated with statins), incompletely addresses the residual CVD risk ... -
Investigation into the relative location of filamin B and YB-1 in cell cycle progression
The cell cycle is a fundamental process in development and the maintenance of homeostasis. Various proteins regulate the cell cycle, such as Y-box binding protein -1 (YB-1). YB-1 transcriptionally regulates cell cycle ... -
Targeted Epigenetic Editing using a dCas9-SunTag Demethylation system
DNA methylation is a stable epigenetic modification, playing a critical role in the regulation of gene expression. Dysregulation of DNA methylation is implicated in the pathogenesis of numerous diseases including cancer. ... -
Regulation of Antigen Presenting Cells by Human Papillomavirus Small Extracellular Vesicles
Human Papillomavirus (HPV) causes over 99% of cervical cancer cases in the world, and of these, over 70% of cases can be attributed to high-risk HPV. There are prophylactic vaccines for HPV, that specifically target high-risk ... -
TP53 in renal vasculitis
Overview: Vasculitis is an autoimmune disease characterised by the swelling and inflammation of blood vessels. Renal vasculitis is a rare, yet severe disease characterised by the inflammation of glomeruli and affiliated ... -
Characterising the Functional and Molecular Determinants for Organ Selective Metastasis in Triple Negative Breast Cancer
Triple-negative breast cancer (TNBC) accounts for 10-20% of primary invasive breast cancer diagnoses, globally. With a higher risk of developing visceral and brain metastasis than other breast cancer subtypes, and limited ... -
The Expression of a p53 Isoform Δ133p53, in the Cell Cycle
Overview: p53 is a principal tumour suppressor protein that regulates the cell cycle. By doing so, p53 prevents damaged cells from undergoing DNA replication and cell division by activating pathways involved in DNA repair, ...