Dunedin School of Medicine
Sub-communities within Dunedin School of Medicine
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Medicine Department [87]
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Pathology Department [66]
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Surgical Sciences [29]
Collections in Dunedin School of Medicine
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Kōhatu – Centre for Hauora Māori [2]
Kōhatu – Centre for Hauora Māori
Recent Deposits
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Atherogenic Index In Plasma and Risk of Cardiovascular Events
As dyslipidaemia is a prominent CVD risk factor, improvements in its management are crucial, as dyslipidaemia (quantified by hypercholesterolemia and treated with statins), incompletely addresses the residual CVD risk ... -
Investigation into the relative location of filamin B and YB-1 in cell cycle progression
The cell cycle is a fundamental process in development and the maintenance of homeostasis. Various proteins regulate the cell cycle, such as Y-box binding protein -1 (YB-1). YB-1 transcriptionally regulates cell cycle ... -
Targeted Epigenetic Editing using a dCas9-SunTag Demethylation system
DNA methylation is a stable epigenetic modification, playing a critical role in the regulation of gene expression. Dysregulation of DNA methylation is implicated in the pathogenesis of numerous diseases including cancer. ... -
Regulation of Antigen Presenting Cells by Human Papillomavirus Small Extracellular Vesicles
Human Papillomavirus (HPV) causes over 99% of cervical cancer cases in the world, and of these, over 70% of cases can be attributed to high-risk HPV. There are prophylactic vaccines for HPV, that specifically target high-risk ... -
Mycobacterial resistance to neutrophil oxidants
Neutrophils are one of the first immune cells to respond when lungs are infected with Mycobacterium tuberculosis – the world’s leading infectious killer that results in millions of deaths every year. Normally, neutrophils ... -
TP53 in renal vasculitis
Overview: Vasculitis is an autoimmune disease characterised by the swelling and inflammation of blood vessels. Renal vasculitis is a rare, yet severe disease characterised by the inflammation of glomeruli and affiliated ... -
Characterising the Functional and Molecular Determinants for Organ Selective Metastasis in Triple Negative Breast Cancer
Triple-negative breast cancer (TNBC) accounts for 10-20% of primary invasive breast cancer diagnoses, globally. With a higher risk of developing visceral and brain metastasis than other breast cancer subtypes, and limited ... -
The Expression of a p53 Isoform Δ133p53, in the Cell Cycle
Overview: p53 is a principal tumour suppressor protein that regulates the cell cycle. By doing so, p53 prevents damaged cells from undergoing DNA replication and cell division by activating pathways involved in DNA repair, ... -
Everything changes : the liminalities of community based palliative care
Introduction: The inspiration for this PhD research developed out of previous research about women with cancer enrolled in the hospice programme. However, not all patients diagnosed with a life threatening illness enrol ... -
Effects of Infraslow Neurofeedback on Alterations in the Cardiovascular Autonomic Nervous System in Healthy Men - A Double Blind Randomised Exploratory Study
Normal functioning of the autonomic nervous system (ANS) is essential for daily life and many clinical populations present with the characteristic of cardiovascular dysregulation. A recent study by our laboratory group ... -
Infection control and latent tuberculosis infection in health care workers in Indonesia
Background: Health care workers (HCWs) and health care students (HCSs), especially in low and middle-income countries (LMICs) are particularly vulnerable to being infected with Mycobacterium tuberculosis. The extent of ... -
Exploring and improving hospital care quality for New Zealand rural communities
Providing sustainable high quality hospital care to people in small towns and rural areas in New Zealand (NZ) is challenging. Little NZ research has explored hospital health care quality in rural communities. Little hospital ... -
Health-Related Quality of Life and Disability among Older People with Chronic Kidney Disease
Background Chronic Kidney Disease (CKD) has been characterised into five stages with CKD5 defined as an estimated glomerular filtration rate (eGFR) of < 15ml/min/1.73m2 and includes those receiving renal replacement therapy ... -
What does it mean to be a Māori doctor? Historical and contemporary perspectives.
Background: Māori are under-represented in the medical workforce; however, numbers of Māori medical doctors are beginning to grow. This research explores what it means to be a Māori doctor utilising Kaupapa Māori methodology. ... -
Vaccination of pregnant women and infant hospitalisation rates for pertussis in Aotearoa
Background While the National Immunisation Schedule includes pertussis-containing vaccines for infants in the first six months, and overall immunisation coverage is over 90% at age 12 months, infants in Aotearoa experience ... -
Advanced Meta-Analysis and Bariatric Surgery
Background: Obesity is one the most important public health concerns worldwide. Randomised clinical trials (RCT) have compared the various bariatric techniques and these have been incorporated in several meta-analyses and ... -
Health and wellbeing of under-15 year olds in Aotearoa 2018
This report is released at a time of renewed focus on the health and wellbeing of children and young people in Aotearoa. In April 2019 Stats NZ released the first round of child poverty statistics using a revised and more ... -
Human papillomavirus gene expression in the placenta and its prevalence in an assisted reproduction cohort
Overview: Human papillomavirus (HPV) is well known as the leading cause of cervical cancer worldwide. Whether HPV also contributes to other adverse effects such as those associated with pregnancy is unclear. Higher incidences ... -
An integrative approach to understanding antimicrobial resistance in New Zealand
Antimicrobial resistance (AMR) occurs when micro-organisms (including bacteria, viruses, fungi and parasites) survive exposure to a medicine that would usually kill them or halt their growth. This is a natural phenomenon ... -
Effects of vasoactive agents on tumour blood flow and cytotoxic drug uptake.
Response of tumours to chemotherapy is limited by resistance, inherent or developing during treatment, causes of which include impaired drug delivery and changes in cellular drug transport. Although high-dose intravenous ...