• Investigation into the relative location of filamin B and YB-1 in cell cycle progression 

  Stratton, Tessa

  The cell cycle is a fundamental process in development and the maintenance of homeostasis. Various proteins regulate the cell cycle, such as Y-box binding protein -1 (YB-1). YB-1 transcriptionally regulates cell cycle ...

• Targeted Epigenetic Editing using a dCas9-SunTag Demethylation system 

  Urbano, Arthur

  DNA methylation is a stable epigenetic modification, playing a critical role in the regulation of gene expression. Dysregulation of DNA methylation is implicated in the pathogenesis of numerous diseases including cancer. ...

• Regulation of Antigen Presenting Cells by Human Papillomavirus Small Extracellular Vesicles 

  Anelay, Lauren Jane

  Human Papillomavirus (HPV) causes over 99% of cervical cancer cases in the world, and of these, over 70% of cases can be attributed to high-risk HPV. There are prophylactic vaccines for HPV, that specifically target high-risk ...

• Mycobacterial resistance to neutrophil oxidants 

  Lorna, Forrester

  Neutrophils are one of the first immune cells to respond when lungs are infected with Mycobacterium tuberculosis – the world’s leading infectious killer that results in millions of deaths every year. Normally, neutrophils ...

• TP53 in renal vasculitis 

  Ho, Nisha

  Overview: Vasculitis is an autoimmune disease characterised by the swelling and inflammation of blood vessels. Renal vasculitis is a rare, yet severe disease characterised by the inflammation of glomeruli and affiliated ...

• Characterising the Functional and Molecular Determinants for Organ Selective Metastasis in Triple Negative Breast Cancer 

  Hong, Helen

  Triple-negative breast cancer (TNBC) accounts for 10-20% of primary invasive breast cancer diagnoses, globally. With a higher risk of developing visceral and brain metastasis than other breast cancer subtypes, and limited ...

• The Expression of a p53 Isoform Δ133p53, in the Cell Cycle 

  Larson, Abbie

  Overview: p53 is a principal tumour suppressor protein that regulates the cell cycle. By doing so, p53 prevents damaged cells from undergoing DNA replication and cell division by activating pathways involved in DNA repair, ...

• Everything changes : the liminalities of community based palliative care 

  McKechnie, Roslyne C.

  Introduction: The inspiration for this PhD research developed out of previous research about women with cancer enrolled in the hospice programme. However, not all patients diagnosed with a life threatening illness enrol ...

• Effects of Infraslow Neurofeedback on Alterations in the Cardiovascular Autonomic Nervous System in Healthy Men - A Double Blind Randomised Exploratory Study 

  Midgelow-Marsden, Bryony

  Normal functioning of the autonomic nervous system (ANS) is essential for daily life and many clinical populations present with the characteristic of cardiovascular dysregulation. A recent study by our laboratory group ...

• Infection control and latent tuberculosis infection in health care workers in Indonesia 

  Apriani, Lika

  Background: Health care workers (HCWs) and health care students (HCSs), especially in low and middle-income countries (LMICs) are particularly vulnerable to being infected with Mycobacterium tuberculosis. The extent of ...

• Exploring and improving hospital care quality for New Zealand rural communities 

  Atmore, Carol

  Providing sustainable high quality hospital care to people in small towns and rural areas in New Zealand (NZ) is challenging. Little NZ research has explored hospital health care quality in rural communities. Little hospital ...

• Health-Related Quality of Life and Disability among Older People with Chronic Kidney Disease 

  Butcher, Elizabeth May

  Background Chronic Kidney Disease (CKD) has been characterised into five stages with CKD5 defined as an estimated glomerular filtration rate (eGFR) of < 15ml/min/1.73m2 and includes those receiving renal replacement therapy ...

• What does it mean to be a Māori doctor? Historical and contemporary perspectives. 

  Sampson, Andrew

  Background: Māori are under-represented in the medical workforce; however, numbers of Māori medical doctors are beginning to grow. This research explores what it means to be a Māori doctor utilising Kaupapa Māori methodology. ...

• Vaccination of pregnant women and infant hospitalisation rates for pertussis in Aotearoa 

  Oben, Glenda; Richardson, Georgia; Duncanson, Mavis

  Background While the National Immunisation Schedule includes pertussis-containing vaccines for infants in the first six months, and overall immunisation coverage is over 90% at age 12 months, infants in Aotearoa experience ...

• Advanced Meta-Analysis and Bariatric Surgery 

  Grainger, Samuel Haru

  Background: Obesity is one the most important public health concerns worldwide. Randomised clinical trials (RCT) have compared the various bariatric techniques and these have been incorporated in several meta-analyses and ...

• Health and wellbeing of under-15 year olds in Aotearoa 2018 

  Duncanson, Mavis; Oben, Glenda; Adams, Judith; Richardson, Georgia; Wicken, Andrew; Pierson, Melanie

  This report is released at a time of renewed focus on the health and wellbeing of children and young people in Aotearoa. In April 2019 Stats NZ released the first round of child poverty statistics using a revised and more ...

• Human papillomavirus gene expression in the placenta and its prevalence in an assisted reproduction cohort 

  Reily-Bell, Ashley

  Overview: Human papillomavirus (HPV) is well known as the leading cause of cervical cancer worldwide. Whether HPV also contributes to other adverse effects such as those associated with pregnancy is unclear. Higher incidences ...

• An integrative approach to understanding antimicrobial resistance in New Zealand 

  Mitchell, Sarah

  Antimicrobial resistance (AMR) occurs when micro-organisms (including bacteria, viruses, fungi and parasites) survive exposure to a medicine that would usually kill them or halt their growth. This is a natural phenomenon ...

• Effects of vasoactive agents on tumour blood flow and cytotoxic drug uptake. 

  Robinson, Bridget Anne

  Response of tumours to chemotherapy is limited by resistance, inherent or developing during treatment, causes of which include impaired drug delivery and changes in cellular drug transport. Although high-dose intravenous ...

• Genome-Wide DNA Methylation in Polycystic Kidney Disease 

  Bowden, Sarah

  Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a heritable renal disease that causes the enlargement of kidneys due to the bilateral development of fluid-filled cysts. This results in end-stage kidney disease in ...

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