• The Twilight Zone of Nucleotide Homology 

  McGimpsey, Stephanie

  Homology search tools are important for inferring homology in the abundance of genomes currently sequenced. These tools utilise sequence similarity in order to assign a score between two sequences from which homology is ...

• Exosome mRNA localisation: Directing mRNA localisation to exosomes 

  Biggs, Harry

  Exosomes are small vesicles containing proteins, miRNAs and mRNAs. Exosomes are secreted and taken up by neighbouring cells and the contents move into the recipient cell, where they are biologically active (e.g. the mRNA ...

• Inhibitory Receptor Expression by T Cells in Colorectal Tumours 

  Leman, Julia Kathleen Hayward

  Inhibitory receptor (iR) expression is a hallmark of T cell dysfunction. In situations of chronic antigen exposure, such as in a tumour, antigen-specific T cells undergo a shift in programming, which makes them more ...

• Investigations into the roles of two flavoproteins in mycobacterial physiology 

  Harold, Liam Karl

  Members of the genus Mycobacterium contain species that are adapted to thrive under a wide variety of environmental conditions. A key factor in the life cycle of mycobacteria is their ability to persist in the absence of ...

• Understanding the genetic basis for competitive nodule formation by clover rhizobia 

  Ferguson, Shaun

  Clovers enter a symbiotic relationship with particular rhizobia through a highly specific and complex signal exchange culminating in the formation of nitrogen-fixing root nodules. Legumes exude flavonoids that are perceived ...

• The morphology of the lumbar paraspinal, gluteal and piriformis muscles in chronic sacroiliac joint pain 

  Kaw, Anu

  The sacroiliac joint (SIJ) can be identified as the source of pain in approximately 10-45% of patients suffering from chronic low back pain. It is hypothesised that SIJ pain may be associated with an imbalance of force ...

• Endosomal SNX Proteins are Required for Recycling of the Epithelial Sodium Channel. 

  Scott, Monique

  The epithelial sodium channel (ENaC) facilitates Na+ absorption of polarised epithelia and is required for regulation of salt and water homeostasis. ENaC’s apical membrane population is strictly controlled, and loss of ...

• The pathophysiological role of microRNAs in diabtic cardiac stem cells 

  Purvis, Nima

  Cardiac stem cells (CSCs) have been implicated as the most suitable source of stem cells in regenerating the diseased heart. However, diabetes is known to cause a progressive loss in the functional efficacy of CSCs. MicroRNAs ...

• The pathophysiology of the cerebello-thalamic pathway in Parkinson's disease. 

  Cameron, Stella

  Parkinson’s disease (PD) presents with characteristic movement deficits that are thought to evolve as a consequence of degeneration of dopamine neurons in the brain. The degree of PD motor symptoms strongly correlates to ...

• Biochemistry and Biophysics of the ASK1-Prdx1 Axis 

  Marshall, James William Andrew

  Peroxiredoxin 1 (Prdx1) is an abundant cytoplasmic human thiol peroxidase. It functions to detoxify reactive oxygen species, in particular, hydrogen peroxide (H2O2). The canonical mechanism of Prdx1 activity involves the ...

• Investigation of Orf virus resistance to interferon 

  Riad, Sherief

  The interferon (IFN) effector response is induced in cells through the JAK/STAT signaling pathway by type 1, type 2 and type 3 IFNs. This results in the upregulation of hundreds of genes, many of which are involved in ...

• The Establishment and Characterisation of Gastric Organoids as a Model for Hereditary Diffuse Gastric Cancer 

  Nouri, Yasmin

  Cancer is an exceptionally complex disease which requires an appropriately sophisticated model to facilitate its research. Organoids are 3D structures generated from stem cells, which recapitulate a target organ. These ...

• The role of molecular genetic variation and population structure in the genetic improvement of the honeybee, Apis mellifera 

  Petersen, Gertje Eta Leony

  Animal breeding has evolved into a highly sophisticated field, making substantial changes to numerous livestock species worldwide. Such changes are largely absent in the Western Honeybee, Apis mellifera. Direct transfer ...

• The Epigenetics of Colorectal Cancer 

  McInnes, Tyler

  Aberrant DNA methylation patterns are a universal feature of cancer, yet we understand relatively little of the cause and consequence of DNA methylation in the cancer process. Colorectal cancer (CRC) morbidity and mortality ...

• Biophysical characterisation of the bacterial chemosensory protein, PscF 

  Boult, Sean Alexander Graham

  In bacteria, movement in response to a chemical stimulus is known as chemotaxis. Chemotaxis is controlled by a class of ligand binding proteins called chemoreceptors and works to bias cell movement towards environments ...

• Flowering time control in legumes: investigation of the photoperiod pathway 

  Napier, Nathanael John

  Understanding how plants integrate environmental and endogenous cues to ensure flowering occurs at a time of highest reproductive success is of significant interest. Flowering time is a key trait in agriculture as flowering ...

• RNF125 activated ubiquitin transfer by Ube2K 

  Fokkens, Thornton J.

  The covalent attachment of ubiquitin to substrate proteins (ubiquitylation) is a post-translational modification involved in numerous cell signalling pathways, most notably the process of protein degradation. Ubiquitylation ...

• Biochemistry of Apoptosis Signal-regulating Kinase 1 Regulation and Hydrogen Peroxide Signalling 

  Weijman, Johannes

  All cells within an organism must respond to their environment. Responses are regulated by intracellular signalling pathways and signalling molecules. One such molecule is hydrogen peroxide (H2O2). H2O2 is required in many ...

• Human epicardial adipose tissue acutely increases atrial fibrillation 

  Babakr, Aram Ahmed

  Epicardial adipose tissue (EAT) is a fat layer that directly contacts the atrial myocardium. Increased EAT mass has emerged as a new risk factor for developing the most common type of irregular heart rhythm, atrial ...

• The Stress and Strain of Triathlon Racing in Different Thermal Environments 

  Creasy, Robert

  Athletic endurance competitions in hot environments have become more relevant in professional sports. The inception for this thesis was to understand why a group of elite endurance triathletes repeatedly failed to perform ...

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