School of Biomedical Sciences
Sub-communities within School of Biomedical Sciences
Collections in School of Biomedical Sciences
-
Anatomy [211]
-
Physiology [140]
Recent Deposits
-
Evolving eusociality: Honeybee queen pheromone induces a starvation response in a non-eusocial insect
Eusociality is a social structure characterised by the reproductive division of labour. A reproductively dominant female or females carry out reproduction, and her subordinate female workers have their reproduction ... -
Elucidating the effects of shear stress on endothelial cell morphology and the expression of ENaC.
The epithelial sodium channel (ENaC) is important for blood pressure regulation through its function within the kidney and arteries, as it is a channel which facilitates the transportation of sodium into the intracellular ... -
Oral delivery of peptides to salmon
Purpose. Oral delivery of peptide and protein drugs to fish has potential advantages to the aquaculture industry. However, the bioavailability of proteins and peptides from the intestinal tract is very low. This can be ... -
ORFV virus manipulation of type I interferon expression
Orf virus (ORFV) is the type species of the Parapoxvirus genus that belongs to the Poxviridae family. ORFV is an epitheliotropic virus inducing cutaneous pustular skin lesions in sheep and goats and is transmissible to ... -
Assessment of the impacts of anthropogenic hybridisation in a threatened non-model bird species through the development of genomic resources with implications for conservation
Interspecific hybridisation—the breeding between distinct species—can contribute to species extinction due to wasted reproductive potential, outbreeding depression, and introgression of genetic material mediated by ... -
Bidirectional promoters for the use of CAR T cell therapy
Cancer is currently a leading cause of death in the world, with 9.6 million deaths in 2018 alone according to the Global Cancer Observatory (GLOBOCAN). Conventional methods such as surgery, chemotherapy, and radiotherapy, ... -
COMMD10 in epithelial sodium channel (ENaC) trafficking
The epithelial sodium channel (ENaC), is assembled as a heterotrimer composed of three homologous subunits α or δ, β, and γ and is selectively permeable to Na+ ions. ENaC plays an essential role in the regulation of sodium ... -
The prehistoric people from Sigatoka : an analysis of skeletal and dental traits as evidence of adaptation
The biological relationships of Pacific people has long been the subject of conjecture and research. Yet very few skeletons older than 1000 years have been recovered and studied. The excavation of 63 skeletons from the ... -
Investigation into the mechanism of action and chemical enhancement of transdermal iontophoreses of LHRH
Recent developments in drug design and advances in mapping of the human genome have quickened the pace of development of peptide and protein drugs. Unfortunately, this class of compound often has specialised delivery ... -
Structural and functional characterisation of glutamate racemase isoform 2 from Acinetobacter baumannii
Acinetobacter baumannii is an opportunistic pathogen associated with high patient mortality within the Intensive Care Unit. The spread of antimicrobial resistance has resulted in some strains carrying up to 45 resistance ... -
The effects of large deletions on beta-lactam resistance in Pseudomonas aeruginosa
Background: P. aeruginosa is an opportunistic pathogen that presents a significant threat to immunocompromised individuals, particularly to those with cystic fibrosis (CF). Chronic lung infection is a major cause of ... -
The immunomodulatory protein, GIF, encoded by orf virus
Inflammatory diseases cause considerable morbidity throughout the world. Examples of inflammatory diseases include rheumatoid arthritis, Crohn’s disease, atherosclerosis and asthma. Current treatments options are insufficient, ... -
Regulation of Ark2C ubiquitylation activity
Ubiquitylation is a post-translational modification that regulates almost all signalling pathways in mammalian cells and its disruption is associated with a range of diseases. Ubiquitylation results in attachment of a small ... -
Evolution of ciprofloxacin resistance in Pseudomonas aeruginosa
Pseudomonas aeruginosa causes a wide range of infections. Ciprofloxacin is one of the most widely used antibiotics for the treatment of these infections. Antibiotic resistance in P. aeruginosa has made its eradication ... -
Cellular bioassays as a clinical tool for monitoring sex steroids
Sex steroid production needs to be maintained within the physiological set point range, deviations outside of the normal range can be a symptom of- and risk factor for endocrine-related diseases (such as polycystic ovarian ... -
Community assembly drivers shift from bottom-up to top-down in a maturing in situ marine biofilm model
Technological advances have promoted the identification of microbial community compositions, but the underlying assembly mechanisms and rules governing successions remain poorly studied and understood. Previous studies ... -
Biosorption of heavy metals from drinking water using fruit and vegetable peels
Heavy metals in drinking water are a serious global concern and efforts are underway to develop sustainable decontamination techniques. The present project was developed with an aim to prepare biosorbents for treating ... -
Annotation and evolution of bacterial ncRNA genes
Successful pathogenic bacteria must alter gene expression in response to changing and hostile environments. Non-coding RNAs (ncRNAs) contribute to adaptability and pathogenicity by forming complex regulatory networks, and ... -
The Effect of rs77275268 on Gene Expression at the Transcriptional Hub at 6q25.1
Breast cancer is a prevalent and harmful disease that is divided into subtypes based on tumour characteristics. The main subtype is oestrogen receptor positive (ER+), accounting for approximately 80% of all breast carcinomas. ... -
Structural insights into oncolytic Seneca Valley Virus capsid and receptor interactions
Oncolytic viruses (OVs) are replication competent agents that selectively target cancer cells. Seneca Valley Virus (SVV) is a newly-discovered oncolytic picornavirus which is classified as the sole member in the genus ...