School of Biomedical Sciences
Sub-communities within School of Biomedical Sciences
Collections in School of Biomedical Sciences
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Anatomy [209]
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Physiology [134]
Recent Deposits
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Investigating a putative neuroprotective pathway in Alzheimer’s disease.
Alzheimer’s disease is a debilitating neurological disorder, the worldwide cost of which has recently entered into the trillions of dollars ($USD) per annum. The primary cause of Alzheimer’s disease is believed to be the ... -
Dissecting alterations to arcuate nucleus neuropeptide Y neural circuitry in a model of polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is the most common form of infertility among women of reproductive age. Despite the prevalence of PCOS, the underlying mechanisms behind how PCOS arises and causes infertility remain poorly ... -
Genetic Evaluation of ESBL E. coli Urinary Isolates in Otago
The incidence of infections with extended spectrum beta-lactamase (ESBL)-producing E. coli in New Zealand is increasing. ESBL E. coli most commonly cause urinary tract infections and are seen in both community and hospital ... -
Chemical and microbial determinants of N2O emission from denitrification in pasture soils
Nitrous oxide (N2O) is a potent greenhouse gas and ozone depleter accounting for 6.2% of globally emitted CO2 equivalents. Denitrification, the microbial reduction of NO3->NO2->NO->N2O->N2, is a significant source of N2O ... -
Stress and sex change in New Zealand spotty wrasse (Notolabrus celidotus)
Sex is fixed from birth in most organisms, where individuals develop as either female or male and retain their sex through life. Traditionally, sex has been considered to be determined by genetic elements or by environmental ... -
oCOm-21 as a Cardioprotective Inotrope Through S-Nitrosylation
Patients with severe ischaemic heart disease (IHD) often undergo cardiac surgery to alleviate symptoms and improve survival outcomes. However, such interventions can inevitably induce episodes of ischaemia reperfusion (IR). ... -
Cardioprotective Potential of the Novel Organic Carbon Monoxide Releasing Molecule (oCOm-21) in Normotrophic and Hypertrophic Hearts
The imposition of ischaemia reperfusion episodes in frequently used cardiac surgery interventions involving cardiopulmonary bypass can induce perioperative complications, such as myocardial injury, arrhythmias, and end ... -
Microbial bioerosion: testing a new technique to differentiate stillborn, perinatal, and neonatal infants in archaeological samples.
First reported by Carl Wedl in 1864, microbial bioerosion is one of the most common and destructive taphonomic processes to act on skeletal material within the archaeological record. It refers to when microbes such as ... -
Expression of O-linked N-acetylglucosamine in the Rat Brain during Pregnancy and Lactation
During pregnancy, adaptations occur in the maternal brain and body to ensure optimal nutrition for both the mother and fetus. Over nutrition in the mother can lead to gestational diabetes mellitus (GDM). GDM in mothers is ... -
The functional role of cardiac non-neuronal cholinergic system in the diabetic heart
In type-2 diabetes mellitus (T2DM), insulin resistance and metabolic derangements reduce glucose transporter-4 (GLUT-4) expression to decrease glucose uptake, and hence the glucose oxidation in the diabetic heart. Further, ... -
The antiviral mechanism and viral antagonism of host histone deacetylase 4 in influenza A virus infection
Influenza virus continues to be an important global pathogen which poses serious health and economic challenges. Influenza virus causes regular seasonal epidemics, intermittent and unpredictable pandemics and deadly zoonotic ... -
Mucosal associated invariant T cells: mechanisms of bacterial control in humans
Mucosal associated invariant T (MAIT) cells are an unconventional T cell subset that are abundant in humans in blood, liver, and mucosal tissues. MAIT cells express a semi-invariant T cell receptor (TCR) (Vα7.2-Jα12/20/33) ... -
Regulation of DEPTOR Ubiquitination by Uric Acid in the Pancreatic β-Cell
As rates of non-communicable disease such as diabetes mellitus raise the questions regarding how these diseases arise becomes more pertinent. One of the major causes of these types of disease is the effects of the modern ... -
The anti-influenza viral mechanism and viral antagonism of host histone deacetylase 6
Influenza virus is a causative agent of respiratory illness called "flu" and is a prototypic member of Orthomyxoviridae family. Influenza viruses are enveloped, negative-sense single stranded RNA viruses with a segmented ... -
DNA methylation memory: Understanding epigenetic reprogramming in vertebrates
DNA methylation is an epigenetic mark critical for vertebrate development and is associated with numerous cellular and organismal processes including X-chromosome inactivation, genomic imprinting, and regulation of gene ... -
Defining the role of respiratory oxidase function in mycobacteria
Members of the Mycobacterium genus are well known for their energetic flexibility, a trait which they exploit to grow and survive under a wide range of oxygen tensions, including hypoxia. Contributing to this flexibility ... -
The forgotten arm of the fight-flight response: α-adrenergic control of the diabetic heart and interactions with Calmodulin Kinase 2
In Type 2 Diabetes Mellitus (T2DM) chronic metabolic stress and associated hemodynamic dysregulation result in a two-fold increase in cardiovascular disease (CVD) risk, making CVD a leading cause of death for T2DM patients ... -
The mortuary practices of three prehistoric sites in northeast Thailand : an interpretation from the perspective of field anthropology
Burials from archaeological sites contain important information and differences between them suggest that the members of a community interred their dead in a specific and intentional manner. To form a comprehensive ... -
Regulation of cardiac ryanodine receptor 2 by protein kinase CK2
The cardiac muscle ryanodine receptor (RyR2) is an intracellular Ca2+ channel responsible for the release of Ca2+ during excitation-contraction coupling. It is also implicated in pathological store-overload-induced Ca2+ ... -
Targeted mutagenesis to investigate the role of low-molecular-weight proteins and a bicarbonate cofactor on the assembly and function of Photosystem II
Photosystem II (PS II) catalyses the oxidation of water at ambient temperatures and the formation of plastoquinol using light. This multisubunit complex functions as a dimer, each monomer is surrounded by 13 low-molecular-weight ...