School of Biomedical Sciences
Sub-communities within School of Biomedical Sciences
Collections in School of Biomedical Sciences
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Anatomy [230]
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Physiology [161]
Recent Deposits
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Early innate immunity against mycobacterial infection
Infection by Mycobacterium tuberculosis is not consistently prevented by the only licensed vaccine, bacillus Calmette-Guérin (BCG). It is widely believed that adaptive immune memory confers protection against tuberculosis ... -
Essentiality of succinate metabolism in Mycobacterium tuberculosis
New drugs are urgently required to combat the tuberculosis epidemic that claims over 1.5 million lives annually. The identification of bedaquiline (BDQ) as an inhibitor of the mycobacterial F1Fo ATP synthase and its ... -
Therapeutic modulation of miRNA-320a to prevent diabetic cardiomyopathy
Recent findings reveal that more than 70% of diabetic individuals are prone to developing some form of heart disease during their life span. Population-based studies have shown that the risk of heart failure is augmented ... -
An investigation to optimise stimulation parameters of Remote Ischaemic Conditioning with digital stimulation
Background: Many ongoing clinical trials are investigating the ability of Remote Ischemic Conditioning (RIC) to limit ischemic injury in major organs such as the heart and brain, focussing on cardiac surgery, myocardial ... -
Decoding the dual target antiactivator QseM
Regulation of transfer of the symbiosis island of Mesorhizobium japonicum strain R7A, ICEMlSymR7A, is tightly controlled by a complex multi-component regulatory system. The master antiactivator of this system is QseM, which ... -
Exploring Neuropathology in delta122p53 Mouse Models
Overview: A role for p53 isoforms in largely promoting cancer has been established. One isoform, ∆133p53, promotes numerous aspects of cancer namely inflammation, proliferation and invasion. Δ133p53 functions are also ... -
Epithelial Sodium Channel in Human Arteries – an Emerging Player in Blood Pressure Regulation
The epithelial sodium channel (ENaC) is a trimer composed of α, β and γ subunits. A fourth ENaC subunit δ has been reported in humans and is known to form a functional channel. There is growing evidence for the function ... -
The impact of anti-CRISPRs on horizontal gene transfer (HGT) and their regulation in mobile genetic elements
CRISPR-Cas systems are common in bacterial genomes, providing adaptive immunity against bacterial viruses (bacteriophages). CRISPR-Cas systems are diverse, with two classes, six types and thirty-three subtypes. Bacteriophages ... -
RCT study comparing the effectiveness of Mixed Reality, Three‐dimensional Monoscopy, and Textbook Style Learning Tools for Anatomical Education in pre‐clinical Medicine
This study, to our knowledge, was the first of its kind which compared the learning tools of textbook style, 3DM, and MR learning tools qualitatively and quantitatively in the short-term anatomy acquisition and retention ... -
The role of D2 and CP43 proteins in the bicarbonate-binding environment of Photosystem II
In Photosystem II (PS II), absorbed light energy is used to transfer electrons from water to a primary plastoquinone electron acceptor (QA) and then to the secondary plastoquinone acceptor (QB). A non-heme iron (NHI) is ... -
Characterisation of conserved amino acids from the low-oxygen expressed D1 protein in the model organism Synechocystis sp. PCC 6803
Oxygenic photosynthesis exploits light, water and carbon dioxide to transform light energy into chemical energy. This process is fundamental in shaping the current oxygenic atmosphere and supports most life on earth. The ... -
Biological characterisation of morphological alterations of the cornea following collagen cross-linking (CXL) treatment
Introduction: Keratoconus (KC) is a disease included in a broader range of conditions called corneal ectasia which leads to spontaneous, non-inflammatory, self-limiting ectasia of the cornea that results in localized corneal ... -
Investigating the roles of specific amino acid substitutions found in the D1' and far-red forms of the Photosystem II reaction centre D1 protein
Photosystem II is a highly conserved membrane-protein complex that plays an integral role in oxygenic photosynthesis as a light-driven water-plastoquinone oxidoreductase. One of the most important proteins within Photosystem ... -
An old drug with new tricks; examining the anti-cancer potential of metformin in mouse and cell models of EML4- ALK+ non-small cell lung cancer
Lung cancer is an aggressive disease producing the highest cancer worldwide. Non-small cell lung cancer (NSCLC) accounts for the majority of all lung cancer cases. The discovery of oncogenic receptor tyrosine kinases (RTKs) ... -
Exploring hot spot mutagenesis as a means of dimer disruption in glutamate racemase from Mycobacterium smegmatis
The emergence of multidrug-resistant Mycobacterium tuberculosis strains has highlighted the need to develop new drugs for the treatment of tuberculosis. Glutamate racemase (MurI) has been identified as an essential enzyme ... -
The Application of Circulating Tumour DNA to the Management of Gastrointestinal Cancers.
Circulating tumour DNA (ctDNA) are small fragments of DNA released by tumours into the circulation. These fragments contain pathogenic mutations which can be detected and quantified by various next generation sequencing ... -
Genetics of gout - Progression from hyperuricaemia to gout
Gout is an inflammatory arthritis that is prevalent in New Zealand (NZ) populations, with a higher frequency in Māori (6.06%) and Pacific Islanders (7.60%) in comparison to NZ Europeans (3.24%). This inflammatory arthritis ... -
Structural violence in Éire: The bone histology of victims from the Great Famine (Kilkenny, Ireland 1845-1852)
This project uses bone histological analysis to explore how disease, diet, and social circumstances affected the bone remodeling of a group of people who died during the Great Famine in Ireland between 1845 and 1852. The ... -
Driving away rats: candidate fertility targets for mammalian gene drives
The dispersal and subsequent proliferation of mammalian invasive species in new environments has significant impacts on food security, disease, and conservation worldwide, particularly in island nations where they have ... -
U-RHYTHM microdialysis: Towards ambulatory metabolodynamics
Rhythms characterise the physiology of all living things, and rhythmic patterns can be observed in almost all aspects of daily human life. Disruption of rhythms is linked to poor health and may be caused by disease, or ...