• Development of a viral chemokine binding protein as a diagnostic tool for chemokine detection. 

  Burgess, Rory

  Chemokines serve an integral role in the inflammatory response, specifically through the development of a chemotactic gradient which directs the trafficking of inflammatory leukocytes to the site of tissue damage or ...

• The effect of removing PsbJ in Synechocystis sp. PCC 6803 mutants that lack the extrinsic proteins of Photosystem II 

  Choo, Peixi

  Photosystem II (PS II) is the light-driven water-plastoquinone oxidoreductase of photosynthesis. PS II consists of 20 protein subunits including four core complexes forming the reaction centre, 13 additional low-molecular-weight ...

• Investigation of ubiquitin transfer by RING E3 ligases RNF121 and RNF114 

  Nguyen, Khanh Hong Truc

  Ubiquitylation is a post-translational modification that modulates protein turnover, function and localisation. The attachment of ubiquitin is achieved by a sophisticated enzyme cascade. Specificity is provided by E3 ...

• Is sarcopenia a neurodegenerative disease? 

  Gillon, Ashley

  Sarcopenia is a major contributor to the loss of independence and deteriorating quality of life in elderly individuals. It is marked by declining skeletal muscle mass and strength beyond the age of 65. Sarcopenia places ...

• The regulation of ascorbate accumulation in plants 

  Chisnall, Matthew Allan Weeber

  Ascorbate (Vitamin C) is vital to human health. We are unable to synthesise ascorbate and attain the majority of ascorbate from plants. Ascorbate accumulation is a complex, regulated and environmentally responsive trait ...

• Characterisation of a new role for the UBA domain in ubiquitin chain synthesis by Ube2K 

  Doorman, Josiah

  Ubiquitylation is a post-translational modification in which the protein Ubiquitin (Ub) is attached to other proteins, dictating their fate. Ubiquitylation requires the action of three groups of enzymes, Ub activating (E1) ...

• The Effect of Raw and Processed Bovine Milk Consumption on Immune Responses in Allergy and Health 

  Shirley, Simon

  A large body of epidemiological evidence shows that children who consume raw bovine milk in early life have reduced incidence of allergies and asthma in later life; while consumption of heat-treated, or processed milk, ...

• The Health Impacts of Increasing Social Inequality in Late Prehistoric Northeast Thailand 

  Ward, Stacey Maree

  Evidence for increasing social inequality and a concurrent health deterioration has been observed in Iron Age (420BCE-500CE) northeast Thailand. Inequality is commonly considered to be represented by variations in quantities ...

• Clinical and Surgical Anatomy of the Ligament of the Head of Femur 

  Perumal, Vivekanandan

  The ligament of the head of femur (LHF), or ligamentum teres, is an intra-articular ligament of the hip joint, running between the transverse acetabular ligament (TAL) of the hip and the fovea capitis femoris (FCF) on the ...

• Toll like receptor signalling in human colonic organoids 

  Samuel, Gaurav

  Three-dimensional primary cultures of colonic epithelium, or colonic organoids, are thought to be a suitable culture system to investigate the properties of human intestinal epithelium and its interaction with commensal ...

• Characterisation of genes involved in exopolysaccharide biosynthesis and transport in the Mesorhizobium loti strain R7A 

  Fowler, Bjorn

  Rhizobia are bacteria that are important in fixing gaseous nitrogen into a plant-available form via a symbiotic interaction with leguminous plants. In order for this to occur, the legume and the rhizobia must communicate ...

• Bioavailability and biological effects of isothiocyanates from broccoli sprout powder 

  Zawari, Masuma

  Broccoli sprout powder (BSP) is a rich source of glucosinolates that can be hydrolysed to isothiocyanates by enzyme myrosinase when the powder comes into contact with water. The major isothiocyanate produced in broccoli ...

• Regulation of Corticotropin-Releasing Hormone Neuron Activity by Noradrenergic Stress Signals 

  Gouws, Julia

  The stress response is crucial for allowing adaptation to an ever-changing external environment. The neuroendocrine stress response is controlled by corticotropin-releasing hormone (CRH) neurons located within the ...

• Maternal obesity affects neurogenesis in the lateral hypothalamic area 

  Twigg, Hannah

  Many human epidemiological studies have reported maternal obesity confers an increased risk for obesity and metabolic disorders within the offspring. Additionally this effect has been observed in numerous animal models of ...

• Transcriptomic and Proteomic Approaches to the Analyses of Orf Virus and its Ankyrin Repeat Proteins 

  Lee, Wen Jiun

  In common with other poxviruses, orf virus (ORFV) is believed to induce drastic changes in the host intracellular environment through expression of an arsenal of virulence factors. The ankyrin repeat (ANK) proteins are ...

• Characterising the role of Vascular ENaC for Blood Pressure Regulation 

  Mugloo, Sama

  Hypertension is characterised by extracellular fluid volume expansion and increased vascular tone. The epithelial sodium channel (ENaC) in the kidney has a central role in maintenance of extracellular fluid volume. In the ...

• Effect of Prolactin on Voluntary Running Behaviour and Locomotion 

  Carter, Kirsten

  The regulation of energy expenditure is crucial for maintenance of energy balance within individuals across variable environments. Neuroendocrine regulation of energy expenditure employs multiple neural populations across ...

• Impact of Dietary Fatty Acids on Neuronal and Metabolic Health 

  Löhfelm, Aline

  In the past decades, the worldwide prevalence of obesity has nearly trebled. This trend is mainly caused by the permanent availability of food, the consumption of a Western-style diet, and the sedentary lifestyle of our ...

• The involvement of the multiple drug resistance family in facial eczema resistance 

  Longley, Meredith

  Facial Eczema (FE) is a disease of ruminants that was first reported in New Zealand at the beginning of this century. Today this disease is considered the most important mycotoxin affecting the sheep industry, causing an ...

• Investigating How Mutations in Cytochrome c Affect the Intrinsic Apoptosis Pathway 

  Wood, Gabrielle

  Cytochrome c is a highly conserved, haem containing protein that usually resides in the mitochondria inter-membrane space. In mitochondria, cytochrome c has a well-known role in the electron transport chain transferring ...

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