• Central Regulation of the Diabetic Heart 

  Sethi, Shivani

  Cardiovascular diseases account for 80% of the premature mortality amongst individuals with Type 2 Diabetes Mellitus (DM). Diabetes is associated with detrimentally higher sympathetic drive to the heart and with disrupted ...

• A Probe for Conformational Change of Hsc70 in Mammalian Cells under Stress Conditions 

  Foster, Jackie

  Hsc70 is a constitutively expressed member of the heat shock protein family. It has an important role in proteostasis and can stabilise nonnative proteins before being further matured in refolding, disaggregation, and ...

• Genetic manipulation of Plasmodium cynomolgi as a model for investigating Plasmodium vivax drug resistance 

  Ward, Kurt Edward

  Plasmodium vivax is the most widely distributed cause of human malaria, and thought to be the most difficult to diagnose and treat. Until recently this species has largely been neglected compared to the most significant ...

• An In Vitro Comparison Study of Two Cell Therapies for Cardiac Repair 

  Yee-Goh, Anthony Soonseng

  Cardiovascular disease continues to be the leading cause of death in New Zealand and throughout the world. Apart from orthotopic heart transplantation, no current treatment can prevent the progression of disease. Due to ...

• Strategies to enhance CAR T cell function in solid tumours utilising coding and non-coding genes 

  Poudel, Aarati

  Cancer immunotherapy has emerged as an effective treatment to provide benefits to cancer patients. One of the main treatment modalities of cancer immunotherapy is the adoptive transfer of T cells with genetically engineered ...

• Mechanisms of bactericidal action and β-lactam synergy by the zinc ionophore PBT2 

  Harbison-Price, Nichaela

  The emergence and global spread of antimicrobial resistance (AMR) is an increasingly serious threat to human and veterinary medicine. Driven by the misuse and overuse of antibiotics, resistance to our antibiotic armoury ...

• Grafting purified cortical pericytes into mouse motor cortex 

  Ganesh, Manju Gayathry

  Brain regeneration through stem cell transplantation studies holds the potential to enhance functional recovery of the damaged brain. Most of the positive effects fostered by transplanted stem cells are believed to be ...

• Chromaffin Cell Ca2+-Responses in Rat Adrenal Medullary Slices 

  Aye, William Wun Tha

  Adrenal medullary chromaffin cells undergo exocytosis of catecholamines to provide physiological and behavioural adaptations during stress. Several different stimuli are known to evoke catecholamine secretion from the ...

• Clinical anatomy of the neurofascial sheath 

  Xu, Zhaoyang

  Background: The peripheral nerve blockade (PNB) and minimally invasive surgery are central to the “Fast Track Surgery” strategy which uses multimodal perioperative rehabilitation programs and aims to facilitate early ...

• The Ratio of RyR2 and CSQ2 in Calcium Handling 

  Sibbles, Elliot

  Atrial fibrillation (AF) is the most common arrhythmia of the heart, affecting 2-3% of the population. AF decreases the quality of life and increases the risk of mortality in patients. Although many patients see improvement ...

• Characterising TRIB1 Nanobodies using a Yeast Surface Display Platform with Flow Cytometry 

  Whitta, Saffron Tian Grelyntan

  The mammalian tribble (TRIB) pseudokinase family has three homologues, which act as an adaptor protein to regulate cell signalling pathways. TRIB proteins can bind the E3 ligase, Constitutive Photomorphogenesis Protein 1 ...

• High Dimensional Analysis of Myeloid Cells in Colorectal Cancer 

  Watts, Amy

  Development of immune therapy requires an in-depth knowledge of immune cells, how they act in a tumour, and how they can be manipulated. Colorectal cancer (CRC) patients have shown less favourable outcomes with immune ...

• Investigating RNF43 Mutations as Biomarkers for ctDNA Surveillance of Colorectal Cancer 

  Lima, Jordon Shae

  This project aimed to investigate the utility of RNF43 mutations for circulating tumour DNA (ctDNA) surveillance of colorectal cancer (CRC). CRC is the second deadliest cancer in New Zealand. CRC patients currently under-go ...

• Investigating the activation of nucleus accumbens projective paraventricular nucleus of the thalamus during cue-food reward conditioning 

  Wang, Mandy

  When a previously neutral cue is learnt to predict a food reward, the presence of the cue itself can elicit the motivation to obtain the food. The nucleus accumbens shell (nAccSh) in the mesolimbic system is involved in ...

• The Role of Lhx9 in the Male Reproductive System 

  Song, Lin

  Leydig cells (LCs) are found within the interstitium of the testes. LCs are crucial to male reproductive function due to their role in testosterone synthesis, a process vital for both organogenesis and secondary sex ...

• Evaluating the Antimicrobial and Antibiofilm Activity of a Lipid Extract from the Giant Kelp Macrocystis pyrifera 

  Qiu, Sophie

  Skin and soft tissue infections (SSTIs) affect millions of individuals worldwide, every year. SSTIs vary in complexity and severity, ranging from superficial skin infections such as impetigo to more severe, polymicrobial, ...

• Impact of carbon monoxide releasing oCOm-21 on the NLRP3 inflammasome 

  Payne, Fergus Micheal

  During cardiac bypass procedure, the heart is subjected to repeat cycles of ischaemia reperfusion injury (IRI). This is highly detrimental to clinical outcomes in patients, presenting as myocardial dysfunction and contributing ...

• Hyperuricemia impairs PAX4 protein expression and plasticity in pancreatic β-cells 

  Abalos, Archelle

  Uric Acid (UA) is a product produced from the metabolic breakdown of purines that is highly associated with several signaling pathways in pancreatic β-cells. High plasma uric acid (hyperuricemia) is associated with gout, ...

• The role of gene duplication and neofunctionalization in the sexual plasticity of teleost fish 

  Edgecombe, Jonika

  Sex determination and differentiation varies widely across vertebrates. In teleost fish these processes are remarkably plastic. In contrast to a gonochoristic system where the sexes are separate, fish that begin life as ...

• A novel leptin receptor mutation causes delayed puberty onset in mice 

  Lord, Rebecca Alexandria

  Reproductive function is tightly controlled by nutritional state due to its high energetic demands. Regulation of fertility according to available energy stores is attained through the integration of metabolic status signals ...

View more