School of Biomedical Sciences
Sub-communities within School of Biomedical Sciences
Collections in School of Biomedical Sciences
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Anatomy [205]
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Physiology [129]
Recent Deposits
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Regulation of cardiac ryanodine receptor 2 by protein kinase CK2
The cardiac muscle ryanodine receptor (RyR2) is an intracellular Ca2+ channel responsible for the release of Ca2+ during excitation-contraction coupling. It is also implicated in pathological store-overload-induced Ca2+ ... -
Targeted mutagenesis to investigate the role of low-molecular-weight proteins and a bicarbonate cofactor on the assembly and function of Photosystem II
Photosystem II (PS II) catalyses the oxidation of water at ambient temperatures and the formation of plastoquinol using light. This multisubunit complex functions as a dimer, each monomer is surrounded by 13 low-molecular-weight ... -
Arterial Hypertension. Consume Carbon Monoxide?
Epithelial sodium channels (ENaC) are generally responsible for the passive movement of sodium ions through the apical cell membrane of salt absorbing epithelia. Canonical ENaC is composed of three homologous subunits, ... -
Characterisation of Arcuate Nucleus Projections to the Paraventricular Nucleus of Thalamus
The metabolic state (fed or hungry) has been shown to influence varying responses to food-associated cues. Recent studies reveal that the paraventricular nucleus of the thalamus (PVT) may play a critical role as it receives ... -
A Novel Oocyte Cryopreservation Method using High Pressure Freezing
Oocyte cryopreservation (egg freezing) involves freezing a female’s oocytes in order to preserve her fertility. These oocytes can later be thawed and fertilised in vitro when she is ready to begin fertility treatment. Women ... -
Bacterial regulation of early activation of mucosal-associated invariant T (MAIT) cells
Mucosal-associated invariant T (MAIT) cells are a population of CD8+ innate-like T cells that play an important role in the immune response to bacterial infections. Being characterised by the expression of a unique ... -
The α-Adrenergic System and CaMKII in Diabetic Heart Disease
The relationship between diabetes mellitus and heart disease is widely documented, with heart disease being the main cause of mortality in diabetic patients. Diabetes impairs the autonomic nervous system, leading to an ... -
The Role of α-ENaC and δ-ENaC in Breast Cancer Cell Migration
Breast cancer is an important disease worldwide, primarily affecting women, and is the most common and deadliest form of female cancer. This is reflected in New Zealand’s population as breast cancer has high incidence and ... -
Candidate Compounds for the Chemoprevention of Hereditary Diffuse Gastric Cancer
Hereditary diffuse gastric cancer (HDGC) is a cancer syndrome caused by germline mutations in the tumour suppressor gene CDH1, which encodes the cell-cell adhesion protein E-cadherin. Mutations in CDH1 lead to increased ... -
Investigation into the Anticancer Mechanism of Action of Novel 4-Substituted Phenylthiazoles and Antihelminthic Benzimidazoles
Recently, two novel 4-substituted phenylthiazoles, D1 and D2, have been synthesised based upon the marine bacterial secondary metabolite anithiactin A/thiasporine C, and shown to be cytotoxic towards cancer cells below 100 ... -
Validation and Characterisation of Novel miRNAs Identified in the E15.5 Mouse Brain
MicroRNAs (miRNAs) are small noncoding elements that downregulate gene expression and play an important role in maintaining robust neurodevelopment. Since abnormal expression of miRNAs has been associated with disorders ... -
uORF-mediated translational regulation of drought stress response gene MASP1 in Arabidopsis thaliana
Human-induced climate variability can subject global regions to water scarcity, prompting widespread crop failure. This calls for innovations that preserve global food security that do not further contribute to climate ... -
Validation and Characterisation of Novel miRNAs Identified in the E15.5 Mouse Brain
MicroRNAs (miRNAs) are small noncoding elements that downregulate gene expression and play an important role in maintaining robust neurodevelopment. Since abnormal expression of miRNAs has been associated with disorders ... -
The role of O-GlcNAcylation in regulating the function and structure of cardiac ryanodine receptors
Diabetes mellitus is projected to be the leading cause of death worldwide by the year 2030 and has been linked to many cardiovascular disorders, which together are known as, diabetic heart diseases (DHDs). DHDs include ... -
Effect of WNT/β-catenin Signalling on T cells in Colorectal Cancer
Worldwide, colorectal cancer (CRC) is the fourth most common cancer and has the second highest mortality rate of any cancer. Only a subset of CRC patients respond to immunotherapies. This lack of response may be due to the ... -
Assessing the efficacy of a fluorescent model of the ovarian reserve in mice
In mammalian females, germ cells proliferate exclusively in development resulting in a finite number of oocytes at birth which are kept in a dormant state within primordial follicles. The ovarian reserve (OR) is the ... -
Investigating the mechanisms driving circadian and sex differences in the stress axis
The stress response allows the body to adapt to an ever-changing environment. Stress results in the activation of corticotrophin releasing hormone (CRH) neurons in the paraventricular nucleus (PVN) of the hypothalamus. ... -
Exploring the protein universe: a study of subdomain driven evolution
Even a relatively short polypeptide of 75 amino acids has more unique sequence possibilities than the number of atoms in the observable universe. Given the vastness of this protein sequence space, the fraction of this space ... -
Growth Inhibition of Mycobacteria by Innate Lymphoid Cells
Tuberculosis (TB) is a lung disease caused by Mycobacterium tuberculosis (Mtb), which was responsible for 1.6 million deaths in 2017. The only vaccine against TB; bacille Calmette Guérin (BCG), protects against miliary and ... -
Characterising the Functional and Molecular Determinants for Organ Selective Metastasis in Triple Negative Breast Cancer
Triple-negative breast cancer (TNBC) accounts for 10-20% of primary invasive breast cancer diagnoses, globally. With a higher risk of developing visceral and brain metastasis than other breast cancer subtypes, and limited ...