• Balancing Safety and Developmental Potency: Assessing the Effect of Antioxidants and TET on Genomic Imprinting Stability. 

  Dunnet, Michael John

  Developmental potency represents the ability of undifferentiated cells to undergo transformation into differentiated cells, with specialised functions. The inner cell mass (ICM) of a blastocyst represents the most ...

• MR1 surface expression on primary blood cells and their role in mucosal associated invariant T (MAIT) cell activation 

  Roman, Tabatha

  Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes that bridge the innate and adaptive immune systems to provide rapid effector responses against a broad range of bacteria. MAIT cells are characterised ...

• Mapping post-stroke brain activation patterns: How do they change over time? 

  Basnayake, Nuvindi

  Stroke is a leading cause of death and long-term disability worldwide. Despite decades of research on neuroprotection, only few therapies are currently available to minimise the extent of infarction. As a result, researchers ...

• Dissecting Estrogen Positive Feedback Mechanisms Using CRISPR-Cas9 

  Orange, Luke

  Estrogen feedback mechanisms are arguably the most important component of mammalian fertility regulation. Estrogen positive feedback is mediated by a population of estrogen receptor alpha (ESR1)-expressing neuronal afferents ...

• Hyperuricemia driven pancreatic β-cell dysfunction through Rictor, a subunit of mTORC2 

  Nolan, Devon James

  The prevalence of diabetes mellitus, specifically type two diabetes mellitus (T2DM), is rapidly rising worldwide prompting research into mechanisms involved in T2DM progression and development. High plasma concentration ...

• Investigating the Mechanisms of Prolactin's Role in Maternal Behaviour 

  Tawngdee, Yasmin

  Prolactin activity in the medial preoptic area (MPOA) of the hypothalamus has been shown to be essential for the display of maternal behaviours in postpartum female mice. Neuronal outputs from the MPOA that express the ...

• The role of the anterior and ventromedial hypothalamic regions in mediating leptin's effect on fertility 

  Nunn, Rachel

  Reproductive function is an energetically demanding process and is therefore tightly regulated by peripheral energy status. This is illustrated by delayed puberty onset and impaired adult reproductive function in individuals ...

• The effects of 5-fluorocytosine on Pseudomonas aeruginosa 

  Thomson, Jessica Margaret

  Pseudomonas aeruginosa is an opportunistic pathogen responsible for a variety of infections. P. aeruginosa presents a challenge to conventional antibiotic therapeutics because of the emergence and rapid spread of antibiotic ...

• Understanding the proapoptotic role of microRNA532 in the diabetic heart 

  Chandrasekera, Dhananjie

  Type 2 diabetes is a metabolic disorder characterised by high glucose levels and insulin resistance. Molecular alterations in the diabetic heart have been shown to accelerate apoptotic cell death. MicroRNAs (miRs) are a ...

• Genomic Evolution and Iron Uptake in Pseudomonas aeruginosa 

  Heywood, Astra

  Recombination and lateral transfer of genomic material between bacterial strains have long been recognised as important to the evolution of a species. Recent developments in sequencing technologies has resulted in a flood ...

• Development of SMA-RL71 as a nanomedicine for the treatment of triple negative breast cancer 

  Martey, Orleans Nii Korley

  Patients diagnosed with triple negative breast cancer (TNBC) have a poor prognosis, due in part to the lack of targeted treatment options. In the search for novel drugs, a second-generation curcumin derivative, ...

• Novel methods for influenza drug research and development: Cloning, expression and purification of influenza neuraminidase for inhibitory assays 

  Campbell, Ashley

  Influenza is a highly contagious virus which can cause mild to severe disease. The most effective drugs for treating influenza, are the neuraminidase inhibitors (NAIs), but resistance to these inhibitors has emerged. New ...

• Selection and Metabolic Disease in the Pacific 

  Cadzow, Murray

  An example of a "signature of selection" in a population is a region of the genome that exhibits a reduction in genetic variability with a particular linkage disequilibrium pattern. This reduction in variation can arise ...

• Bulbing and flowering regulation in bulb onion (Allium cepa L.) 

  Khosa, Jiffinvir Singh

  Bulb onion is an important vegetable crop cultivated worldwide for salad and culinary purposes. Onions have a biennial life cycle; during the first year the bulb is formed followed by flowering in the second year. The bulb ...

• SLC2A9 and Hyperuricemia: A Locus-Wide Association Study To Identify Population-Specific Genetic Variants In New Zealand Māori and Pacific People 

  Parthasarathy, Padmini

  Hyperuricemia, pathologically defined as the presence of an elevated level of serum urate, is a prerequisite for gouty arthritis. The solute carrier family 2 member 9 (SLC2A9) gene that encodes a urate transporter tops the ...

• Investigation into the transcriptional regulation of DUO1: determining the fate of the male germline in flowering plants 

  Peters, Benjamin Arthur

  The pollen grain is responsible for the production and delivery of sperm cells to the female gametes in flowering plants. Early in pollen development, there is an asymmetric division that is critical for the specification ...

• Comparison of FRET probes of conformational changes in DnaK and Hsc70 

  Campbell, Eugene

  Hsp70s are one of the most well conserved protein families known, yet little of their in vivo activity is understood and experimental resources required to investigate their activity. All Hsp70s are made up of two highly ...

• The role of the SVP gene family in controlling bud dormancy 

  Wu, Rongmei

  SHORT VEGETATIVE PHASE (SVP)-like genes in the StMADS11 gene family have roles in the regulation of flowering time in annual plants and there is evidence that they also function in the regulation of dormancy in perennials. ...

• Mining bioactive peptides from sheep cheese whey β-lactoglobulin using food grade proteases 

  Sunde, Hannah

  Sheep cheese whey (SCW) is a by-product of the cheese making process that is often considered waste and treated as an environmental pollutant. This research project stemmed from a recent change in view that rather than ...

• Working towards an understanding of Facioscapulohumeral Muscular Dystrophy 

  Denny, Adam

  Facioscapulohumeral muscular dystrophy (FSHD) is genetic myopathy which is inherited in an autosomal dominant manner. FSHD is the third most common form of muscular dystrophy, affecting approximately 1:7500 individuals ...

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