• Factors Affecting The Advancement Of Atherosclerotic Plaques 

  Ebenebe, Obialunanma

  Cardiovascular disease (CVD) is the leading cause of death worldwide in adult men and women. Atherosclerotic cardiovascular disease (ASCVD) has been highlighted as the main cause of death among CVDs, due to development and ...

• Hybrid Assembly of the Chytrid Genome - Insights into the Evolution and Outbreak of a Major Amphibian Pathogen 

  Sumpter, Nicholas Andrew

  Devastating amphibian population declines have been observed globally for the last 40 years. These declines have become the interest of several conservationists and researchers, as amphibians form a valuable part of global ...

• The regulation of ascorbate in apples (Malus domestica) 

  Steffert, Katie

  Ascorbate is an essential biochemical for biological processes in plants and animals. Ascorbate concentrations vary greatly between closely related species of plants, and can even differ across cultivars of the same species. ...

• Characterisation of the ubiquitin E3 ligase COP1 

  Curry, Jack Richard

  Constitutive photomorphogenic 1 (COP1) is a ubiquitin E3 ligase that has been implicated in development of a variety cancers. The goal was to characterise the ubiquitin E3 ligase activity of COP1 and the relationship between ...

• Investigation of RING domain E3 ubiquitin ligases in regulation of delta epithelial sodium channel (δENaC) activity 

  Ly, Kevin Thang Vinh

  The delta epithelial sodium channel subunit (δENaC), is a member of ENaC family of channels that are essential for sodium homeostasis and blood pressure regulation. Although the role of δENaC has yet to be established it ...

• Anatomy of microvenous valves of normal and venous ulcerated lower limbs 

  Phillips, Mark N.

  Venous disease is a very common disease that affects millions of people worldwide. While some of the factors that cause the development of varicose veins are well understood, the aetiology of venous ulceration is poorly ...

• Spatiotemporal patterns of prokaryotic communities in New Zealand agricultural soils 

  Kaminsky, Rachel

  New Zealand pasture soils are an important resource, contributing significantly to the economy and global food security. However, the sustainability of current land management practices is of great concern, leading researchers ...

• Health risk assessment and health risk management with special reference to sodium monofluoroacetate (1080) for Possum control in New Zealand 

  Foronda, Natalia M

  The principal use of sodium monofluoroacetate (1080) in New Zealand is to control brushtail possums (Trichosurus vulpecula). Aerial application of baits containing 1080 is the most common method used for large-scale control ...

• Development of ‘Targeted’ Genotyping-by-Sequencing in Atlantic salmon (Salmo salar) 

  Caulton, Alexandra Jane

  Selective breeding is a fundamental component of sustainable animal and plant production1. Traditionally, the aquaculture industry has lagged behind its agricultural counterparts with respect to utilisation of genomic ...

• Modulating the immune response to colorectal cancer in mice using a chitosan gel vaccine 

  Niemi, Ginny

  Vaccines modulate the host’s anti-tumour immune response and represent an area of emerging immunotherapy research for the treatment of cancer, including colorectal cancer (CRC). Murine subcutaneous (SC) injections of tumour ...

• The Development of Circulating Tumour DNA as a Clinical Surveillance Tool for New Zealand Breast Cancer Patients 

  Parackal, Sarah Grace

  Breast cancer is a heterogeneous group of diseases where metastatic spread is the major cause of death. Surveillance of treatment response and tumour burden is currently achieved with periodic medical imaging over the ...

• Agriculture in Northern Chile’s Atacama Desert: Implications for Human Skeletal and Dental Growth of Early Pre-Hispanic Populations 

  Elliott, Gail Elizabeth

  This project tests the theoretical model predicting human health deterioration with the development and intensification of agriculture in northern Chile (Cohen and Armelagos 1984). Research from North America and Europe ...

• Dissecting the ontogeny and functional relevance of altered GABAergic circuitry in Polycystic Ovary Syndrome (PCOS) 

  Silva, Mauro Sergio Batista da

  Polycystic ovary syndrome (PCOS) is the most common cause of female infertility worldwide, yet this prevalent endocrine disorder remains poorly understood. Although classically considered an ovarian disease, altered brain ...

• Retromer associated sorting nexins SNX1, SNX4, and SNX27 and the trafficking and basolateral membrane population of the intermediate conductance calcium activated potassium channel (KCa3.1) in polarised epithelial cells 

  Pilmore, Elliot James

  The intermediate conductance calcium (Ca 2+)-activated potassium (K+) channel (KCa3.1) is targeted to the basolateral membrane of polarised epithelial cells, and is also found in many nonepithelial cell types. KCa3.1 ...

• Understanding the Batten disease associated protein CLN5 

  Yip, Jade Jasmine Ruyi

  The neuronal ceroid lipofuscinoses (NCL, Batten disease) are a group of inherited neurodegenerative lysosomal storage diseases (LSD) that typically result in loss of vision, epilepsy, loss of motor function and cognitive ...

• Synergistic Synthetic Lethal Drug Combinations for E-Cadherin-Deficient Cancers 

  Single, Andrew Bruce

  E-cadherin is a cell-to-cell adhesion protein encoded by the gene CDH1. Germline inactivating mutations in CDH1 underpin hereditary diffuse gastric cancer (HDGC), an autosomal dominant disease that strongly ...

• Genetic Predisposition to Gastric Cancer: CDH1 and Beyond 

  Hakkaart, Christopher

  Gastric cancer is a complex disease influenced by strong genetic and environmental factors. Hereditary gastric cancer syndromes are thought to account for between 1-3% of all cases. The most common hereditary gastric cancer ...

• Changes in AMPA Receptor Subunit Expression in the Somatosensory Cortex of the Stargazer Mouse Model of Absence Epilepsy 

  Adotevi, Nadia Kafui

  Childhood absence epilepsy (CAE) is the most common early-onset epilepsy accounting for about 10-17% of all paediatric epilepsies. It is a genetic generalized, non-convulsive form of epilepsy characterized by a sudden and ...

• A Synthetic Lethal Approach to the Development of Novel Cancer Therapies 

  Beetham, Henry

  The cell-cell adhesion protein E-cadherin (CDH1) is a tumour suppressor that is required to maintain cell adhesion, cell polarity and cell survival signalling. Somatic mutations in CDH1 are common in diffuse gastric cancer ...

• Structural and Proteomic Analysis of ΦTE, a Phage Infecting Pectobacterium atrosepticum 

  Tong, Brian

  Bacteriophages are extremely diverse and are also far more numerous than any other organism on Earth. Despite this diversity, there still remain many unanswered questions regarding their structures, what (and how) forces ...

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