School of Biomedical Sciences

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Department of Biochemistry [173]

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Recent Deposits

Engineering the activities and specificities of a glycerol dehydratase and an alcohol dehydrogenase

Maddock, Danielle (Thesis, Doctor of Philosophy, 2017)

There is growing interest in finding renewable, environmentally friendly routes to chemicals that are traditionally derived from crude oil. The use of bacteria as living factories for the biosynthesis of these chemicals ...
Mechanisms of the contribution of vasopressin to the development of hypertension

Korpal, Aaron Kumar (Thesis, Doctor of Philosophy, 2017)

Plasma vasopressin levels are paradoxically elevated in some hypertensive patients. Vasopressin is secreted from the posterior pituitary gland by magnocellular neurosecretory cells (MNCs) located in the paraventricular ...
How Bone Marrow Mesenchymal Stem Cells Influence the Metastasis of Breast Cancer

Squires, Chloe Margaret Lorraine (Thesis, Master of Science, 2017)

Mesenchymal stem cells (MSCs) are multipotent non-haematopoietic cells primarily originating from within the bone marrow. Physiologically they aid in the process of wound healing. However, MSCs are also recruited by cancer ...
Anticancer Potential of Novel Curcumin Analogues towards Hormone-Refractory Prostate Cancer

Chen, Shuli (Thesis, Master of Science, 2017)

Prostate cancer, a hormonally driven and dependent malignancy, is a leading cause of cancer-related deaths in men. Hormonal therapy including surgical castration and medical/chemical castration to cause regression of ...
Low dose inhaled carbon monoxide and cardiac ischaemia reperfusion injury

Parry, Dominic James (Thesis, Master of Medical Science, 2017)

INTRODUCTION Low dose carbon monoxide (CO), a byproduct of heme oxygenase, has been shown to cause vasodilatation, modify platelet adherence, reduce inflammation and inhibit apoptosis. Cardiac ischaemia-reperfusion (IR) ...
Functional Conservation Of The Male Germ-line Regulator DUO1 In Flowering Plants

Casey, Jonathan (Thesis, Master of Science, 2017)

In flowering plants the development of the male germ-line in pollen to form two functional sperm cells is essential for reproduction. DUO1 an R2R3 MYB transcription factor plays a key role in regulating genes required for ...
Developing peptidomimetics of secreted amyloid precursor protein-alpha (sAPPα) that confer neuroprotection and stimulate novel protein synthesis

Lawson, Nicholas (Thesis, Master of Science, 2017)

FDA drug approval process takes years to reach manufacturing, development is 2-10 years, pre-clinical treatment another 3-6, clinical trails 6-7 years and finally FDA review, another 1-2 years. This a long process due to ...
The Chemokine-binding Proteins Encoded by Bovine Papular Stomatitis Virus and Parapoxvirus of Red Deer in New Zealand: Molecular and Functional Characterization

Sharif, Saeed (Thesis, Doctor of Philosophy, 2017)

Poxviruses are large DNA viruses that infect a wide range of animals including humans. During the course of evolution, these complex viruses have gained an extensive repertoire of immunomodulatory genes to evade host immune ...
N cycling and microbial dynamics in pasture soils

Samad, Md Sainur (Thesis, Doctor of Philosophy, 2017)

Pasture soils are a significant source of the greenhouse gas, nitrous oxide (N2O) and as such they contribute to global warming. It has been reported that N2O is approx. 300 times more potent than carbon dioxide (CO2) as ...
Identifying the best source of autologous progenitors for cardiac regeneration

Dixit, Parul (Thesis, Doctor of Philosophy, 2017)

Preliminary efficacy data indicates that stem cell transplantation has the potential to enhance myocardial perfusion and/or contractile performance in patients with ischemic heart disease. A significant challenge in ...
Development of In-vitro Skin Models for Thermal Injury; to Investigate the Impact of Commensal Staphylococcus species on Wound Healing

Fleming, Jodie Sarah Min Lei (Thesis, Master of Science, 2017)

Skin is the largest organ of the body protecting our internal organs from physical injury, microbial invasion and infection. Healthy skin homeostasis relies on the interaction between the skin’s physical properties, its ...
Neutrophil killing of Staphylococcus aureus In Sepsis

Nazari, Shekufah (Thesis, Master of Science, 2017)

Neutrophils form the majority of circulating white blood cells and play a principle role in defending the body against invasions by microorganisms. Neutrophils engulf microorganisms into a phagosome where they kill them ...
Phenotypic and Molecular Analysis of the Alanine and Glutamate Racemases of Mycobacteria

Mortuza, Roman (Thesis, Doctor of Philosophy, 2017)

The enzymes alanine racemase (Alr) and glutamate racemase (MurI) catalyze the formation of the essential building blocks, D-alanine and D-glutamate, respectively, for cell wall biosynthesis. Despite their essential cellular ...
The role of anti-Müllerian hormone in the brain’s response to steroid hormones

Sirisomboonwong, Korawan Erika (Thesis, Bachelor of Biomedical Sciences with Honours, 2017)

Many sexual dimorphisms that exist in the brain develop in the postnatal period. For males, this is when testosterone levels are minimal and anti-Müllerian hormone (AMH) is elevated. Testosterone requires the enzyme aromatase ...
The Antiviral Potential of Host Histone Deacetylase 11 during Influenza Virus Infection

Nutsford, Ashley (Thesis, Master of Science, 2017)

Influenza A virus (IAV) continues to have a major impact on global public health by causing regular seasonal epidemics, unpredictable pandemics and zoonotic outbreaks. These events also have significant implications for ...
The role of calcium calmodulin dependent protein kinase II in type 2 diabetic heart dysfunction

Daniels, Lorna Jane (Thesis, Doctor of Philosophy, 2017)

Type 2 diabetes is a well-established risk factor for cardiovascular disease, with the landmark Framingham study in the 1970’s reporting the incidence of heart failure is significantly higher in diabetic (DM) patients ...
Regulation of Zn2+ and aggregation affects Aβ1-42- induced changes in cell culture viability.

Potemkin, Nikita (Thesis, Master of Science, 2017)

In the story of the pathogenesis of Alzheimer’s Disease, Amyloid-Beta (Aβ) is believed to play a key role. However, evidence suggests that metal ions, in particular Zn2+, may have strong modulatory, or even causative effects ...
A protective role for exercise in the age-related loss of muscle mass

Nielsen, Kathrine Bjerregaard (Thesis, Doctor of Philosophy, 2017)

Sarcopenia, the age-related loss of muscle mass and function is an impending health issue for the vast majority of people as they reach their sixties and this decline progressively reduces life quality for the affected ...
Translational regulation of vitamin C production in plants

Ritchie, Erin Samantha (Thesis, Master of Science, 2017)

Ascorbate is an essential biochemical for plants and animals, as it a powerful antioxidant and an enzyme co-factor. In higher plants, ascorbate is synthesised via the Smirnoff-Wheeler pathway, which is primarily regulated ...
COMMD10 Regulates Protein Trafficking

Ware, Adam William (Thesis, Doctor of Philosophy, 2017)

The epithelial sodium channel (ENaC) is a heterotrimeric, amiloride-sensitive Na+ channel located at the plasma membrane of various tissues, including kidneys and the vasculature. ENaC abundance and activity at the plasma ...