School of Biomedical Sciences
Sub-communities within School of Biomedical Sciences
Collections in School of Biomedical Sciences
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Anatomy [185]
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Physiology [110]
Recent Deposits
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The role of PsbX and PsbY in Photosystem II of Synechocystis sp. PCC 6803
Photosystem II (PS II) is the water-plastoquinone oxido-reductase responsible for splitting water in photosynthesis. The core of the enzyme is surrounded by 13 low-molecular-weight (LMW) proteins (<10 kDa). In this study, ... -
The impact of hepatic steatosis on liver circulation, transplantation, ischaemia-reperfusion injury and its relation with nitrous oxide
Obesity is now a major health threat in the developed world. To investigate the impact of obesity-induced steatosis on hepatic blood flow, portal venous and hepatic arterial blood flow were measured in the anaesthetized ... -
Shear Force Activation of the Epithelial Sodium Channel (ENaC): Role of the β- and γ-Subunits
Mechanotransduction describes the ability of a living organisms to sense mechanical forces that are caused through changes in the environment. It is a complex mechanism in which mechanical forces are converted into a ... -
BCG impact on Innate Lymphoid Cells: Determining the Site of Proliferation
Tuberculosis (TB) is an infectious lung disease that is a major cause of mortality, causing an estimated 1.7 million deaths globally per year. The current prophylactic vaccine used against TB, bacille Calmette Guérin (BCG), ... -
The role of Numb in honeybee ovary activation
Environmental signals in utero are throught to induce plastic changes to metabolism and gene regulation, causing diseases such as Type 2 Diabetes. For example, fetal undernutrition is associated with obesity, hyperglycemia, ... -
The role of the mTOR-Raptor complex in driving hyperuricemia-induced diabetes mellitus
Elevated serum uric acid (hyperuricemia) when left untreated can lead to a range of pathologies including gout, cancer and type 2 diabetes mellitus (T2DM). It has been shown that after three days of exposure to hyperuricemic ... -
Analysing components of the Torso-activation module: Do they pattern the end-terminal regions of two Hymenopteran insect species, Apis mellifera and Nasonia vitripennis?
This project sought to determine if components of the Torso-activation module pattern the embryonic anterior and posterior ends of the honey bee, Apis mellifera, and the parasitoid wasp, Nasonia vitripennis via a patterning ... -
Disarming tissue factor: generating a model tumour antigen
Coagulative abnormalities are a well-recognised feature of malignancy. The risk of developing thrombotic disorders is increased four-fold in cancer patients and more than six-fold higher in those receiving chemotherapy. ... -
Investigating Teixobactin Tolerance in Enterococcus faecalis
The rapid rise of antimicrobial resistance (AMR) poses a global threat to human health. Key to combating antimicrobial resistance will be to increase our understanding of how resistance develops. Conventional antimicrobial ... -
Characterisation of a phase-variable restriction-modification system in Enterococcus faecalis
The gastrointestinal colonizer Enterococcus faecalis is an opportunistic, multi-drug resistant pathogen and a leading cause of nosocomial infections. Vancomycin- resistant enterococci (VRE) are of particular concern and ... -
Identification of AH1-specific T cells in a mouse model of colorectal cancer
Colorectal cancer (CRC) causes approximately 1.4 million new cases of disease and 700,000 deaths worldwide annually. To overcome limitations of studying CRC in humans, mouse models are used to test therapeutics such as ... -
Identifying the role of connexin 43 in transport of microRNAs
Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Present treatments for CVD rely heavily on surgical interventions and drug therapies that relieve symptoms rather than cure the disease. Therefore, ... -
The Impact of Epithelial Sodium Channel on Breast Cancer Cell Migration
Breast cancer is the most common cancer in New Zealand women, with the majority of breast cancer deaths being due to metastasis. This highlights the importance of identifying regulators and, thus, potential therapeutic ... -
Sodium and Uric Acid as Modulators of Vascular Endothelial ENaC
Hypertension, defined as a chronically high blood pressure, is a significant risk factor for heart attacks and strokes. Despite hypertension affecting 28% of individuals over the age of 20 years old, little is known about ... -
Modulation of Lineage Development in the Colonic Epithelium
Despite being exposed to microbial and food antigens, the human gastrointestinal tract does not exist in a state of inflammation. This homeostasis is critically dependent on the colonic epithelial barrier, which when ... -
Balancing Safety and Developmental Potency: Assessing the Effect of Antioxidants and TET on Genomic Imprinting Stability.
Developmental potency represents the ability of undifferentiated cells to undergo transformation into differentiated cells, with specialised functions. The inner cell mass (ICM) of a blastocyst represents the most ... -
MR1 surface expression on primary blood cells and their role in mucosal associated invariant T (MAIT) cell activation
Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes that bridge the innate and adaptive immune systems to provide rapid effector responses against a broad range of bacteria. MAIT cells are characterised ... -
Mapping post-stroke brain activation patterns: How do they change over time?
Stroke is a leading cause of death and long-term disability worldwide. Despite decades of research on neuroprotection, only few therapies are currently available to minimise the extent of infarction. As a result, researchers ... -
Dissecting Estrogen Positive Feedback Mechanisms Using CRISPR-Cas9
Estrogen feedback mechanisms are arguably the most important component of mammalian fertility regulation. Estrogen positive feedback is mediated by a population of estrogen receptor alpha (ESR1)-expressing neuronal afferents ... -
Hyperuricemia driven pancreatic β-cell dysfunction through Rictor, a subunit of mTORC2
The prevalence of diabetes mellitus, specifically type two diabetes mellitus (T2DM), is rapidly rising worldwide prompting research into mechanisms involved in T2DM progression and development. High plasma concentration ...