School of Biomedical Sciences

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Department of Biochemistry [170]

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Recent Deposits

Development of In-vitro Skin Models for Thermal Injury; to Investigate the Impact of Commensal Staphylococcus species on Wound Healing

Fleming, Jodie Sarah Min Lei (Thesis, Master of Science, 2017)

Skin is the largest organ of the body protecting our internal organs from physical injury, microbial invasion and infection. Healthy skin homeostasis relies on the interaction between the skin’s physical properties, its ...
Neutrophil killing of Staphylococcus aureus In Sepsis

Nazari, Shekufah (Thesis, Master of Science, 2017)

Neutrophils form the majority of circulating white blood cells and play a principle role in defending the body against invasions by microorganisms. Neutrophils engulf microorganisms into a phagosome where they kill them ...
Phenotypic and Molecular Analysis of the Alanine and Glutamate Racemases of Mycobacteria

Mortuza, Roman (Thesis, Doctor of Philosophy, 2017)

The enzymes alanine racemase (Alr) and glutamate racemase (MurI) catalyze the formation of the essential building blocks, D-alanine and D-glutamate, respectively, for cell wall biosynthesis. Despite their essential cellular ...
The role of anti-Müllerian hormone in the brain’s response to steroid hormones

Sirisomboonwong, Korawan Erika (Thesis, Bachelor of Biomedical Sciences with Honours, 2017)

Many sexual dimorphisms that exist in the brain develop in the postnatal period. For males, this is when testosterone levels are minimal and anti-Müllerian hormone (AMH) is elevated. Testosterone requires the enzyme aromatase ...
The Antiviral Potential of Host Histone Deacetylase 11 during Influenza Virus Infection

Nutsford, Ashley (Thesis, Master of Science, 2017)

Influenza A virus (IAV) continues to have a major impact on global public health by causing regular seasonal epidemics, unpredictable pandemics and zoonotic outbreaks. These events also have significant implications for ...
The role of calcium calmodulin dependent protein kinase II in type 2 diabetic heart dysfunction

Daniels, Lorna Jane (Thesis, Doctor of Philosophy, 2017)

Type 2 diabetes is a well-established risk factor for cardiovascular disease, with the landmark Framingham study in the 1970’s reporting the incidence of heart failure is significantly higher in diabetic (DM) patients ...
Regulation of Zn2+ and aggregation affects Aβ1-42- induced changes in cell culture viability.

Potemkin, Nikita (Thesis, Master of Science, 2017)

In the story of the pathogenesis of Alzheimer’s Disease, Amyloid-Beta (Aβ) is believed to play a key role. However, evidence suggests that metal ions, in particular Zn2+, may have strong modulatory, or even causative effects ...
A protective role for exercise in the age-related loss of muscle mass

Nielsen, Kathrine Bjerregaard (Thesis, Doctor of Philosophy, 2017)

Sarcopenia, the age-related loss of muscle mass and function is an impending health issue for the vast majority of people as they reach their sixties and this decline progressively reduces life quality for the affected ...
Translational regulation of vitamin C production in plants

Ritchie, Erin Samantha (Thesis, Master of Science, 2017)

Ascorbate is an essential biochemical for plants and animals, as it a powerful antioxidant and an enzyme co-factor. In higher plants, ascorbate is synthesised via the Smirnoff-Wheeler pathway, which is primarily regulated ...
COMMD10 Regulates Protein Trafficking

Ware, Adam William (Thesis, Doctor of Philosophy, 2017)

The epithelial sodium channel (ENaC) is a heterotrimeric, amiloride-sensitive Na+ channel located at the plasma membrane of various tissues, including kidneys and the vasculature. ENaC abundance and activity at the plasma ...
Fundamental and applied investigations into mycobacterial bioenergetics

Hards, Kiel Jason (Thesis, Doctor of Philosophy, 2017)

From the war on drug resistance, through cancer biology, even to agricultural and environmental protection; there is a huge demand for rapid and effective solutions to infections and diseases. The development of small ...
The use of CRISPR sequences to investigate the prokaryotic adaptive immune system and its targets

Croft, Bradley (Thesis, Master of Science, 2017)

Bacteria and archaea are in a constant arms race against viruses and mobile genetic elements (MGEs). Recently the clustered regularly interspaced short palindromic repeats (CRISPR) system was discovered to function as an ...
Regulatory pathways dependent on the RseP protease in Pseudomonas aeruginosa

Jiang, Yida (Thesis, Master of Science, 2017)

The opportunistic pathogen P. aeruginosa is responsible for a wide range of infections and is wide spread in many soils and human surroundings. In order to survive, the bacteria overcome limited iron bio-availability by ...
Characterising the effect of shear force on the activity of the epithelial sodium and acid sensing ion channels

Barth, Daniel Stefan (Thesis, Doctor of Philosophy, 2017)

Mechanosensation is the ubiquitous ability of cells to sense and respond to their mechanical environment and has been linked to the activation of ion channels. Members of the DEG/ENaC ion channel protein family including ...
To the Caribbean and Beyond: Complete Mitogenomes of Ancient Guinea Pigs (Cavia porcellus) as a proxy for Interaction in the Late Ceramic Age.

Lord, Edana Jean (Thesis, Master of Science, 2017)

The late ceramic age in the Caribbean occurred from AD500 and was associated with increased interaction between the islands and mainland South America. The domestic guinea pig (Cavia porcellus) was introduced to the Caribbean ...
Investigation into the Role of ARMT1 in Oestrogen Receptor Positive Breast Cancer

Dainty, Kimberley (Thesis, Master of Science, 2017)

Breast cancer is the most common malignancy in women and accounts for more than 400,000 deaths per year worldwide. Oestrogen receptor alpha -positive (ER+) tumours account for approximately 80% of all breast tumours. A ...
An investigation into specific therapeutic targeting of the HIV-1 translational frameshift element

Rolfe, Jack (Thesis, Master of Science, 2017)

HIV-1 is a pathogenic retrovirus, which often develops into acquired immune deficiency syndrome (AIDS) and inevitably leads to death. The virus has directly caused an estimated 36 million deaths worldwide, and is the second ...
Effects of Gestational Nutrition on Post-Natal Fertility in Sheep

Smith, Peter Raymond (Thesis, Doctor of Philosophy, 2017)

Changes to feed availability resulting from global climate change have the potential to exacerbate fertility issues already facing the NZ livestock industry. Appropriate feeding levels during gestation is gaining more ...
Infant and childhood growth and developmental stress during the intensification of agriculture at Ban Non Wat, Thailand.

Dhavale, Neha (Thesis, Doctor of Philosophy, 2017)

The adoption and intensification of agriculture resulted in several alterations within the physical and socio-cultural environment that had long-term consequences on human health in many parts of the world. This thesis ...
A Role for Calcium Calmodulin-Dependent Protein Kinase II in the Early Development of Atherosclerosis

Worthington, Luke (Thesis, Master of Science, 2017)

Atherosclerosis is the leading cause of cardiovascular death in the developed world. Endothelial dysfunction is an early event in the development of atherosclerosis and is characterised by increased reactive oxygen species ...