University of Otago, Christchurch School of Medicine and Health Sciences
Collections in University of Otago, Christchurch School of Medicine and Health Sciences
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Anaesthesia [3]
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Population Health [23]
Recent Deposits
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Quality of life is quality of life is quality of life : the views of older people ageing in place
Quality of life is a concept that has been subject to considerable academic gaze from mainly a quantitative perspective. Qualitative descriptions have been limited to conceptualising quality of life from a health perspective. ... -
External Validation of Consensus Molecular Subtyping of Colorectal Adenocarcinoma
Background: Colorectal cancer (CRC) is the second most diagnosed cancer in New Zealand, and New Zealand has amongst the highest rates per capita of CRC in the world. CRC is a highly heterogeneous disease with varying ... -
Magnetic resonance imaging of saccadic eye movements in Parkinson’s disease
Parkinson’s disease (PD) is a progressive neurodegenerative disorder with cardinal signs of bradykinesia, tremor, rigidity and postural instability. Current PD treatment only alleviate symptoms of PD, however, there is an ... -
Complex Regional Pain Syndrome (CRPS) physiotherapy management: a cohort, observational, prospective, longitudinal study across the South Island of New Zealand
Physiotherapy management for CRPS is considered to be essential. However, there is a lack of validated evidence-based treatments. There is controversy between what treatment methods are safe or effective. Physiotherapy ... -
The Canterbury Ileal Pouch-Anal Anastomosis Study
Background and aim: Inflammatory bowel disease (IBD) is an increasingly prevalent chronic disease, frequently with an early age of onset and no cure. It is important to ascertain which treatments are effective and ... -
Diet, Microbiota and Metabolic Health
Diabetes is one of the largest global health crises, affecting some 415 million adults worldwide, with type 2 diabetes mellitus (T2DM) accounting for at least 90% of all cases of diabetes. In line with international ... -
Targeted Enrichment and Nanopore Sequencing of RNA Transcripts from Breast Cancer Risk Genes
Aberrant alternative splicing of hereditary breast and ovarian cancer genes has been associated with an increased susceptibility for breast and/or ovarian cancer. However, studying the effects of gene variants on splicing ... -
Aspirin’s role in preventing E-cadherin cleavage by the carcinogenic Bacteroides fragilis toxin
Carriage of enterotoxigenic Bacteroides fragilis (ETBF) in the colonic mucosa is associated with increased risk of pre-cancerous lesions. Antibiotics will not selectively eradicate these bacteria, but toxin-mediated host ... -
Intracellular redox changes during TNFα-mediated necroptosis
Necroptosis is a form of regulated cell death triggered by a variety of factors associated with infection and inflammation. It is distinct from the well-characterised cell death processes of apoptosis and necrosis, sharing ... -
CNVs and familial breast and ovarian cancer
BRCA1 pathogenic variant carriers experience a high risk of developing breast and ovarian cancer, however, differences in risk vary greatly between individuals. The advent of genetic testing has presented an increasing ... -
Can vitamin C reduce metastasis in a mouse model of breast cancer?
Ascorbate supplementation has been shown to reduce the aggressiveness of tumours in ascorbate-dependent Gulo-/- mice using both melanoma and lung cancer models. To date there is limited information on breast cancer growth ... -
The Impacts for the Registered Nurses of the New Entry to Specialty Practice Mental Health and Addiction Nursing Programme, of the Programme, on their Personal and Professional Development
A qualified and competent nursing workforce is critical to the health and wellbeing of any society. New Entry to Specialty Practice Mental Health and Addiction Nursing (NESP) programmes were developed in New Zealand to ... -
Talking about menopause: Exploring the lived experience of menopause for women working in the health sector
As the participation of women in the workplace has grown, so too has the need to live through menopause in a more public way. Previously managed in private, many women now experience (often visible) menopausal changes at ... -
The comparative assessment of patient safety at hospitals in New Zealand
Patient safety is the avoidance, prevention and amelioration of adverse outcomes or injuries stemming from the healthcare system. Patient safety is the most important constituent of quality and has become increasing important ... -
Oxidative post-translational modifications of calprotectin during inflammation
Calprotectin, a heterodimer of S100A8 and S100A9 subunits, is an abundant cytosolic neutrophil protein. It is released from neutrophils upon their activation or as a result of cell disruption or death. Extracellular levels ... -
The role of ascorbate in controlling hypoxia factors in renal cell carcinoma
Clear cell RCC (ccRCC) is the most common and also most aggressive RCC type harbouring alterations in the VHL tumour suppressor gene leading to uncontrolled accumulation of pro-survival hypoxia inducible transcription ... -
Effective interventions for Māori with bipolar disorder: A qualitative study
This study explores the perspectives of clinicians and others knowledgeable in hauora Māori in describing effective interventions when caring for Māori diagnosed with bipolar disorder. Māori, who are the indigenous people ... -
What Factors Are Associated With Guideline Use and Compliance?
Introduction Clinical guidelines are recommendations targeted at medical professionals which aim to optimise patient care. When successfully implemented, clinical guidelines have been shown to improve processes of care ... -
Experiences of opioid detoxification using ibogaine in various treatment settings: Exploring ibogaine users’ motivations, understanding of risks, and effects of ibogaine treatment
Introduction Opioid dependence is a significant health concern in New Zealand. It has been estimated that there are 10,000 people who are daily or almost daily intravenous users of opioid drugs, half of whom are receiving ... -
The effects of obesity-related hormones on cancer cells
Introduction: Obesity is a significant risk factor in the development of endometrial cancer and poses a serious health threat. Furthermore, morbidities related to obesity are associated with a significantly increased risk ...