University of Otago, Christchurch School of Medicine and Health Sciences
Sub-communities within University of Otago, Christchurch School of Medicine and Health Sciences
Collections in University of Otago, Christchurch School of Medicine and Health Sciences
-
Anaesthesia [3]
-
Population Health [32]
Recent Deposits
-
Motion measurement algorithms for MARS imaging
The goal of the MARS molecular imaging team is to advance medicine by researching, developing, and commercialising spectral CT systems. This thesis presents the work I performed to facilitate live imaging with MARS scanners. ... -
Development of hydrogel-based strategies for tissue vascularisation
The tissue engineering field and regenerative medicine has emerged as a promising strategy to overcome the lack of availability of organs and tissue grafts for transplantation. One of the main challenges in the field is ... -
Contested boundaries: E-scooter riders’ and pedestrians’ experiences of sharing space
Globally, e-scooters have become a popular mode of transport with the arrival of shared e-scooter services in cities and the availability of e-scooters for private purchase. E-scooters represent an exciting opportunity to ... -
Gene expression variability in breast tumour development
Breast cancer is the most common female malignancy and presents a major health issue both worldwide and in New Zealand. Individuals with a family history of either breast or ovarian cancer have an increased lifetime risk ... -
Clinical handover from the operating theatre nurse to the post anaesthetic care unit nurse: a New Zealand perspective
The perioperative environment is complex, it encompasses multiple teams of health professionals and numerous transitions of patient care, requiring effective teamwork and communication to avoid negative patient outcomes. ... -
Vitamin C as an Epigenetic Therapeutic for Acute Myeloid Leukaemia
Acute myeloid leukaemia (AML) is a deadly disease characterised by the abnormal proliferation of immature blood cells in the bone marrow with a block in haematopoietic differentiation. The disease is heterogeneous, and ... -
Bacterial Lipopolysaccharide and Immune Activation in Colorectal Cancer
Colorectal cancer (CRC), is the second deadliest cancer in New Zealand. At early stages tumours can be treated with surgery or a combination of surgery and chemotherapy. However, once the cancer has metastasized, treatment ... -
Development of detection methods for Legionella longbeachae in clinical and environmental samples
Legionella longbeachae is the predominant causative agent of Legionnaires’ disease (LD) in New Zealand with a peak infection period during the spring and summer months. This is a plant-associated microbe that can be found ... -
The interaction of neutrophils and amyloid-ß in Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that affects memory and cognition. A key molecular pathological hallmark of AD is amyloid-ß deposition. Amyloid-ß is a small aggregation-prone peptide ... -
The immune system: A common link mediating exercise effects on the tumour microenvironment and skeletal muscle mitochondria?
Exercise reduces the risk of developing a range of different cancers and has been associated with improved cancer patient survival. However, preclinical studies suggest that in some cases, exercise may be ineffective or ... -
Neutrophils and cancer: regulation of cell death and epigenetic pathways
Neutrophils constitute a significant proportion of recruited immune cells in many tumours. While activated neutrophils are able to exert robust anti-tumoural effects, more often they provide growth and survival signals ... -
A socio-spatial analysis of pedestrian falls in Aotearoa New Zealand
This report summarises the results of a study undertaken in 2019 to examine the built environment around the location of pedestrian falls in New Zealand using existing spatial data. Please see the publisher link for the ... -
Cognitive impairment and conversion to dementia in Parkinson's disease: an imaging study of amyloid PET and diffusion MRI
Objective To investigate the association between amyloid deposition or white matter degeneration with cognitive impairment and conversion to dementia in Parkinson’s disease (PD). Background Cognitive decline and ... -
MARS molecular imaging: Potential clinical utility of spectral photon-counting computed tomography integrated with nanoparticle technology
The aim of the research documented in this thesis was to investigate molecular imaging using a MARS spectral scanner. This scanner is a photon-counting computed tomography (CT) system that simultaneously measures 5-8 ... -
E-cadherin and APC in early-onset colorectal cancer
Colorectal cancer (CRC) is a considerable health burden being the second highest cause of cancer deaths globally. While overall cases of CRC have been declining worldwide, there has been an increase in the incidence of the ... -
The Development and Delivery of a Specialised Multidisciplinary Pain Management Group Programme for Women with Chronic Pelvic Pain
Background Chronic Pelvic Pain (CPP) affects around one in five women. Despite high healthcare usage, management of CPP is often unsuccessful resulting in high levels of disability and costs to society. Despite recognition ... -
High novelty seeking as a predictor of antisocial behaviour in early adulthood
Objective: This study aimed to examine the association between novelty seeking (NS) and antisocial behaviours (age 18–35). Method: A New Zealand general population birth cohort was studied from 1977 to 2012. Sample sizes ... -
Ethnic Differences in Adolescent Mental Health Problems: Examining Early Risk Factors and Deviant Peer Affiliation
Using life-course longitudinal data from the Christchurch Health and Development Study (CHDS), we examined ethnic differences in rates of psychiatric disorder among New Zealand adolescents, comparing New Zealand M?ori to ... -
The role of novelty seeking as a predictor of substance use disorder outcomes in early adulthood
Background and aims: There has been a great deal of evidence showing that high novelty seeking (NS) is a risk factor for the development of substance use disorders (SUDs). However, the possible causal role of NS in SUDs ... -
Epidemiological foundations for the insurance hypothesis: Methodological considerations
Nettle et al. evaluate evidence for the insurance hypothesis, which links obesity with the perception of food scarcity. Epidemiological findings in this area have generally been weak and inconsistent. The present commentary ...