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University of Otago, Christchurch School of Medicine and Health Sciences

University of Otago, Christchurch School of Medicine and Health Sciences

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Collections in University of Otago, Christchurch School of Medicine and Health Sciences

Anaesthesia [2]
Centre for Postgraduate Nursing [37]
Maori/Indigenous Health Institute (MIHI) [1]
Medicine - Christchurch [31]
Obstetrics and Gynaecology - Christchurch [2]
Orthopaedic Surgery and Musculoskeletal Medicine [3]
Paediatrics - Christchurch [4]
Pathology - Christchurch [48]
Population Health [19]
Psychological Medicine - Christchurch [22]
Radiology and the Centre for Bioengineering [4]
Surgery - Christchurch [5]

Recent Deposits

The Lived Experience of Person-Centred Care in Residential Homes in New Zealand and Singapore: The perspectives of Residents, Frontline Caregivers and Family Members

Sundarajoo, Sarathambal (Thesis, Doctor of Philosophy, 2017)

Ageing is an inevitable part of life. The intent to age gracefully and in a dignified manner is held as important by many, but a number of challenges can influence an individual’s ability to control their lives at an older ...
Development, validation and application of a liquid chromatography tandem mass spectrometry assay for uracil and 5,6-dihydrouracil along with 5-fluorouracil and its metabolites, in human plasma

Chavani, Ottiniel (Thesis, Master of Medical Laboratory Science, 2017)

5-Fluorouracil (5-FU), a pyrimidine analogue, is one of the commonly prescribed chemotherapeutic drugs for solid tumours, principally of the digestive tract, breast plus head and neck. Conventional 5-FU dose normalisation ...
The key components of cancer nurse coordination: An integrative review

Kerr, Christine (Thesis, Master of Health Sciences, 2016)

With one in three New Zealanders experiencing a diagnosis of cancer during their lifetime, the New Zealand (NZ) national health care system plays a pivotal role in providing services to ensure optimal health outcomes for ...
Application of emerging sequencing and genomic technologies to diagnostic molecular genetics.

Kennedy, Hannah Louise (Thesis, Doctor of Philosophy, 2017)

The advent of massively parallel sequencing (MPS) has provided much broader opportunities in the field of molecular genomics. Previously, sequencing approaches were limited to a small number of single genes or exons. MPS ...
The role of hydrogen sulfide, substance P and Kupffer cells on inflammation and liver sinusoidal endothelial cells in sepsis

Gaddam, Ravinder Reddy (Thesis, Doctor of Philosophy, 2017)

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. The inflammatory response is an integral part of sepsis and leads to the systemic inflammatory response syndrome (SIRS) and ...
Characterisation of the x-ray source and camera in the MARS spectral system

Shamshad, Muhammad (Thesis, Doctor of Philosophy, 2017)

This thesis reports on the characterisation of two modules of the MARS spectral CT system: the x-ray source and the x-ray camera. Understanding each of them directly improves material identification and quantification. A ...
Genetic variation and mRNA splicing in familial breast cancer genes

Lattimore, Vanessa (Thesis, Doctor of Philosophy, 2017)

Germline variants in high-penetrance breast cancer susceptibility genes BRCA1 and BRCA2 are often identified through routine diagnostic gene screening, typically performed for individuals from high-risk breast-ovarian ...
Neuropsychological Functioning and Ghrelin Secretion in Women with Binge Eating

Taylor, Kathryn Jan (Thesis, Doctor of Philosophy, 2017)

Aims: Binge eating disorders have a substantial impact on the lives of those affected, both psychologically and physically. The trend towards using a transdiagnostic model to understand binge eating disorders highlights ...
Coping with the Impact of Multiple Sclerosis: A Grounded Theory Study

Keramat Kar, Maryam (Thesis, Doctor of Philosophy, 2017)

Introduction: Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system. MS generally progresses gradually, with alternating periods of remission, good health and disabling flare-ups. The ...
Exploring the anti-cancer and anti-inflammatory properties of isothiocyanates

Spencer, Emma Sue (Thesis, Doctor of Philosophy, 2017)

Isothiocyanates are a class of phytochemicals responsible for the characteristic tastes and odours of cruciferous vegetables. Epidemiological evidence indicates that increased consumption of isothiocyanates is associated ...
Personality Associations with Mood, Hoarding, Health and Well-being

Spittlehouse, Janet Katherine (Thesis, Doctor of Philosophy, 2017)

Background: Personality has been of interest since ancient times. Hippocrates, also known as ‘The father of Western Medicine’ was possibly the first to document the association between personality and mental and physical ...
Nutrition therapy for active Crohn's disease

Wall, Catherine (Thesis, Doctor of Philosophy, 2017)

Exclusive enteral nutrition (EEN) is a first line treatment for active paediatric Crohn’s disease (CD) but is used less frequently in adult patients. A meta-analysis of six controlled trials in adults found EEN to be less ...
Alcohol-related psychiatric comorbidity

Foulds, James (Thesis, Doctor of Philosophy, 2017)

Background Alcohol problems and common mental disorders, particularly depression, contribute greatly to the global burden of disease and they often coexist. However, many aspects of the relationship between these two ...
Are we ready yet?: New graduate nurses' experience of workplace violence and agression and their sense of readiness

Ball, Christine (Thesis, Master of Health Sciences, 2017)

Aim: The aim of this study was explore new graduate nurses’ experience of WPVA and their sense of readiness for responding to such events. Background: Considerable evidence exists indicating that workplace violence and ...
The reactions of superoxide with tyrosyl radicals on proteins

Das, Andrew Bejoy (Thesis, Doctor of Philosophy, 2017)

Superoxide is continuously removed from cells by superoxide dismutase (SOD). Genetic knockout studies have shown that SOD is crucial for survival, suggesting that higher levels of superoxide are damaging. Tyrosyl radicals ...
Effectiveness and safety of vitamin D compounds in people with chronic kidney disease: A systematic review and meta-analysis

Okamura-Kho, Amy (Thesis, Bachelor of Medical Science with Honours, 2016)

Vitamin D therapy is commonly prescribed for people with chronic kidney disease to improve biochemical perturbations; however, evidence of effects on patient-centred outcomes such as mortality, cardiovascular events and ...
A novel strategy to prevent bacterial biofilm formation using methylthioadenosine-nucleosidase inhibitors

Swadi, Tara Harith (Thesis, Bachelor of Biomedical Sciences with Honours, 2016)

Each year there are approximately 2.9 million joint replacement surgeries performed worldwide. Great efforts have been made to reduce infection rates in these replacements in the past and yet these rates have not decreased ...
A Validation Study to Detect Markers of Proliferation Adequacy in the Endometrium

Burn, Rosamond Sarah (Thesis, Bachelor of Biomedical Sciences with Honours, 2016)

Throughout the human female menstrual cycle, the endometrial lining of the uterus transitions from a non-receptive proliferative state to a receptive secretory state. This transition is required to prepare the endometrium ...
The Influence of Exercise and Hyperlipidaemia on Breast Cancer

Buss, Linda (Thesis, Bachelor of Biomedical Sciences with Honours, 2016)

Exercise reduces the risk of breast cancer development, and improves survival in breast cancer patients. However, the underlying mechanisms of this protective effect remain to be fully elucidated. It is unclear whether ...
Nanopore Sequencing of RNA from Breast Cancer Genes

de Jong, Lucy Clair (Thesis, Bachelor of Biomedical Sciences with Honours, 2016)

Abnormal mRNA splicing can disrupt gene function and influence the course of disease. Analysis of abnormal splicing is an important part of determining whether a particular genetic variant found in the population is ...