University of Otago, Christchurch School of Medicine and Health Sciences
Collections in University of Otago, Christchurch School of Medicine and Health Sciences
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Anaesthesia [2]
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Population Health [23]
Recent Deposits
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Targeted Enrichment and Nanopore Sequencing of RNA Transcripts from Breast Cancer Risk Genes
Aberrant alternative splicing of hereditary breast and ovarian cancer genes has been associated with an increased susceptibility for breast and/or ovarian cancer. However, studying the effects of gene variants on splicing ... -
Aspirin’s role in preventing E-cadherin cleavage by the carcinogenic Bacteroides fragilis toxin
Carriage of enterotoxigenic Bacteroides fragilis (ETBF) in the colonic mucosa is associated with increased risk of pre-cancerous lesions. Antibiotics will not selectively eradicate these bacteria, but toxin-mediated host ... -
Intracellular redox changes during TNFα-mediated necroptosis
Necroptosis is a form of regulated cell death triggered by a variety of factors associated with infection and inflammation. It is distinct from the well-characterised cell death processes of apoptosis and necrosis, sharing ... -
CNVs and familial breast and ovarian cancer
BRCA1 pathogenic variant carriers experience a high risk of developing breast and ovarian cancer, however, differences in risk vary greatly between individuals. The advent of genetic testing has presented an increasing ... -
Can vitamin C reduce metastasis in a mouse model of breast cancer?
Ascorbate supplementation has been shown to reduce the aggressiveness of tumours in ascorbate-dependent Gulo-/- mice using both melanoma and lung cancer models. To date there is limited information on breast cancer growth ... -
The Impacts for the Registered Nurses of the New Entry to Specialty Practice Mental Health and Addiction Nursing Programme, of the Programme, on their Personal and Professional Development
A qualified and competent nursing workforce is critical to the health and wellbeing of any society. New Entry to Specialty Practice Mental Health and Addiction Nursing (NESP) programmes were developed in New Zealand to ... -
Talking about menopause: Exploring the lived experience of menopause for women working in the health sector
As the participation of women in the workplace has grown, so too has the need to live through menopause in a more public way. Previously managed in private, many women now experience (often visible) menopausal changes at ... -
The comparative assessment of patient safety at hospitals in New Zealand
Patient safety is the avoidance, prevention and amelioration of adverse outcomes or injuries stemming from the healthcare system. Patient safety is the most important constituent of quality and has become increasing important ... -
Oxidative post-translational modifications of calprotectin during inflammation
Calprotectin, a heterodimer of S100A8 and S100A9 subunits, is an abundant cytosolic neutrophil protein. It is released from neutrophils upon their activation or as a result of cell disruption or death. Extracellular levels ... -
The role of ascorbate in controlling hypoxia factors in renal cell carcinoma
Clear cell RCC (ccRCC) is the most common and also most aggressive RCC type harbouring alterations in the VHL tumour suppressor gene leading to uncontrolled accumulation of pro-survival hypoxia inducible transcription ... -
Effective interventions for Māori with bipolar disorder: A qualitative study
This study explores the perspectives of clinicians and others knowledgeable in hauora Māori in describing effective interventions when caring for Māori diagnosed with bipolar disorder. Māori, who are the indigenous people ... -
What Factors Are Associated With Guideline Use and Compliance?
Introduction Clinical guidelines are recommendations targeted at medical professionals which aim to optimise patient care. When successfully implemented, clinical guidelines have been shown to improve processes of care ... -
Experiences of opioid detoxification using ibogaine in various treatment settings: Exploring ibogaine users’ motivations, understanding of risks, and effects of ibogaine treatment
Introduction Opioid dependence is a significant health concern in New Zealand. It has been estimated that there are 10,000 people who are daily or almost daily intravenous users of opioid drugs, half of whom are receiving ... -
The effects of obesity-related hormones on cancer cells
Introduction: Obesity is a significant risk factor in the development of endometrial cancer and poses a serious health threat. Furthermore, morbidities related to obesity are associated with a significantly increased risk ... -
MUSIC for Medical Students: Validation of the MUSIC Model of Academic Motivation in New Zealand
Introduction/background: An important aspect of student learning is that of academic motivation. Academic motivation can be defined as “a process that is inferred from actions … and verbalizations …, whereby goal- directed ... -
Data entry into a spinal cord injury registry: a qualitative exploration of clinicians’ perceptions, influences and barriers
Background In the current health sector there is a demand for high-quality data and research. Registries are a potential source of high-quality data, but whether it is more appropriate for clinicians or clerical staff to ... -
An exploration of the development of advanced rural nursing in the Australian and New Zealand primary health care setting : an integrative review
Background Advanced rural nursing roles have evolved in response to the international need to address the complex and dynamic health care system and to meet the demand for flexibility in health service delivery. There has ... -
Influence of Risk Factors on Incidence, Management, Recurrence, and Follow-up of Acute Diverticulitis.
Acute Diverticulitis is a significant problem, accounting for up to one third of acute surgical admissions. Despite significant and rapid advances in medical knowledge, it remains a poorly understood disease. Practice ... -
The Global Health Classroom: Collaborative Global Health Learning between New Zealand and Samoan Medical Students in a Virtual Classroom
Background Global Health is recognised as an essential component of undergraduate medical curricula to equip future doctors with the relevant knowledge, attitudes, and skills to practice in a globalised world. The Global ... -
Longitudinal magnetic resonance imaging of cognitive impairment in Parkinson’s disease
Parkinson’s disease (PD) is a neurodegenerative movement disorder characterized by slowness of movement, rigidity, and tremor. However, most patients additionally develop cognitive impairment and eventual dementia (PDD), ...