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University of Otago, Christchurch School of Medicine and Health Sciences
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University of Otago, Christchurch School of Medicine and Health Sciences
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Collections in University of Otago, Christchurch School of Medicine and Health Sciences
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Anaesthesia [2]
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Population Health [21]
Recent Deposits
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(Thesis, Bachelor of Biomedical Sciences with Honours, 2017)Immune checkpoint inhibitors (ICIs) have drastically improved the clinical outcome for many cancer patients. However, not all patients treated with ICIs show a clinical response and the development of a unique spectrum of ... -
(Thesis, Doctor of Philosophy, 2017)Suicide is considered to be a serious health and social issue and the improvement of services that cater for those affected by mental disorder is one of the principal targets for suicide prevention. All cases of suspected ... -
(Thesis, Master of Medical Laboratory Science, 2017)Carboplatin is a chemotherapy drug used in a variety of cancers with the primary toxicity being exposure-dependant myelosuppression. We present the development and validation of a simple, robust inductively coupled plasma ...
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(Dissertation, Master of Public Health, 2015)Homelessness is a broad and somewhat blunt term to describe a complex concept. Beneath the concept and many varied definitions are people who are living with inadequate, insecure or no housing at all; these are often among ... -
(Thesis, Doctor of Philosophy, 2017)Abdominal aortic aneurysm (AAA) is a permanent dilatation of the infrarenal segment of the abdominal aorta which can be fatal if the aneurysm ruptures. Ruptured AAA is the second leading cause of global surgical mortality, ... -
(Thesis, Master of Medical Science, 2017)Introduction Mild Traumatic Brain Injury (mTBI) has been described as a ‘silent epidemic’ and is a significant health burden to the global population. New Zealand specific data estimates mTBI to occur 749 in 100,000 ... -
(Thesis, Master of Health Sciences, 2017)The first comprehensive national study on the opinions and attitudes of the New Zealand addiction workforce in addressing coexisting problems (CEP) was carried out by Gilbert (2010) using a telephone survey. The aim of ... -
(Thesis, Doctor of Philosophy, 2017)Today, upwards of 10 million people—approximately 9 500 of whom reside in New Zealand—are living with Parkinson’s disease (PD). Yet, the means of diagnosing PD remain somewhat similar to those available to James Parkinson ... -
(Thesis, Doctor of Philosophy, 2017)This thesis describes a series of interrelated studies that I performed to characterize two key modules of MARS spectral CT scanner: the x-ray source and the x-ray detector. Characterizing and optimizing the outputs of ... -
(Thesis, Master of Public Health, 2017)Due to the potential for serious and widespread outbreaks of waterborne disease, managing the risk of microbiological contamination of drinking water is of particular importance. In New Zealand, drinking water quality and ... -
(Thesis, Doctor of Philosophy, 2017)Ageing is an inevitable part of life. The intent to age gracefully and in a dignified manner is held as important by many, but a number of challenges can influence an individual’s ability to control their lives at an older ... -
(Thesis, Master of Medical Laboratory Science, 2017)5-Fluorouracil (5-FU), a pyrimidine analogue, is one of the commonly prescribed chemotherapeutic drugs for solid tumours, principally of the digestive tract, breast plus head and neck. Conventional 5-FU dose normalisation ...
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(Thesis, Master of Health Sciences, 2016)With one in three New Zealanders experiencing a diagnosis of cancer during their lifetime, the New Zealand (NZ) national health care system plays a pivotal role in providing services to ensure optimal health outcomes for ... -
(Thesis, Doctor of Philosophy, 2017)The advent of massively parallel sequencing (MPS) has provided much broader opportunities in the field of molecular genomics. Previously, sequencing approaches were limited to a small number of single genes or exons. MPS ... -
(Thesis, Doctor of Philosophy, 2017)Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. The inflammatory response is an integral part of sepsis and leads to the systemic inflammatory response syndrome (SIRS) and ... -
(Thesis, Doctor of Philosophy, 2017)This thesis reports on the characterisation of two modules of the MARS spectral CT system: the x-ray source and the x-ray camera. Understanding each of them directly improves material identification and quantification. A ... -
(Thesis, Doctor of Philosophy, 2017)Germline variants in high-penetrance breast cancer susceptibility genes BRCA1 and BRCA2 are often identified through routine diagnostic gene screening, typically performed for individuals from high-risk breast-ovarian ... -
(Thesis, Doctor of Philosophy, 2017)Aims: Binge eating disorders have a substantial impact on the lives of those affected, both psychologically and physically. The trend towards using a transdiagnostic model to understand binge eating disorders highlights ... -
(Thesis, Doctor of Philosophy, 2017)Introduction: Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system. MS generally progresses gradually, with alternating periods of remission, good health and disabling flare-ups. The ...
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(Thesis, Doctor of Philosophy, 2017)Isothiocyanates are a class of phytochemicals responsible for the characteristic tastes and odours of cruciferous vegetables. Epidemiological evidence indicates that increased consumption of isothiocyanates is associated ...
