Anatomy
Recent Deposits
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‘A healthy and prosperous future’ – a histological exploration of childhood stress experiences in early settler communities of Otago
This thesis investigates the childhood physiological stress experiences of mid-nineteenth century European and Chinese settlers in Otago, New Zealand, through the histological examination of enamel formation disruption. ... -
Effects of In Utero Exposure to Methamphetamine on Brain Development
Methamphetamine (MA) is a stimulant to the central nervous system that has highly addictive properties, which can cause an increase in poor health outcomes in those affected. With a major increase in the use of MA worldwide, ... -
The impact of maternal immune activation on offspring: implications for schizophrenia
Schizophrenia is a devastating life-long psychiatric disorder with manifestation in late adolescence or early adulthood. Epidemiological research shows that prenatal exposure to viral or bacterial infection during the ... -
Concussion episodes: A creative-critical project on poetry and brain injury
Concussion Episodes is a creative-critical PhD project that examines representations of brain injury across medical literature, life writing, fiction, and poetry. It explores the representational tendencies of each genre ... -
Revisiting human and animal relationships in prehistoric Near Oceania: An archaeogenetic approach
The social histories and cultural identities of Near Oceania (Australia, New Guinea, the Bismarck Archipelago, and the Solomon Islands) are entwined in people’s relationships with their animals and environments and are ... -
Defining Leptin-Responsive nNOS Neurons for Puberty and Fertility
Reproduction is a resource intensive process by which animals propagate their genes, hence it must be coordinated carefully with the body’s availability of energy stores to produce viable offspring. The adipocyte-derived ... -
Investigating the inflammatory response within the ageing oviduct
One in four people attempting to conceive will experience infertility. The current theory is that infertility is caused by a decreased number and quality of eggs in the ovary. However, ovarian aging cannot be the sole cause ... -
The Overlooked Transition from Undergraduate to Postgraduate Study
The aim of the current research was to define the transition and experiences of first-time postgraduate students. As demonstrated by participant interviews, Honours and PGDip are a unique level of study that offer students ... -
Novel glycosaminoglycan mimetic's show therapeutic potential in post-stroke recovery
Each year, millions of people are affected by stroke resulting in death or long-term disabilities. Due to improvements in stroke treatment resulting in improved survival following having a stroke, more stroke survivors are ... -
Effect of Pregnancy on Forced Exercise in Mice
During pregnancy and lactation, a wide range of metabolic changes occur, all of which exist to ensure a healthy pregnancy occurs. One of these reductions is exercise with women typically reducing their exercise levels, ... -
The Role of PACAP Neurons in the Control of Metabolism and Fertility by Leptin
The reproductive or Hypothalamic-Pituitary-Gonadal (HPG) axis is tightly regulated by its own internal negative feedback system, as well as by external factors such as the body’s stress responses. One key regulatory ... -
Investigating Genomic Imprinting in the Brushtail Possum
While almost all mammalian genes express their maternally and paternally inherited copies equally, a small subset of genes (~100 in humans) are subject to parent-specific expression. This peculiar form of gene expression, ... -
From phylum to population: Environmental DNA for New Zealand biodiversity
Biodiversity, the variability of all living organisms, is declining at a rapid rate. To effectively target efforts for preventing biodiversity loss, monitoring declining diversity is necessary. Surveying efforts include ... -
A morphological study of the deep muscles in the flexor compartment of the leg
Purpose: The deep muscles in the flexor compartment of the leg, comprised of tibialis posterior (TP), flexor digitorum longus (FDL) and flexor hallucis longus (FHL) contribute to ankle plantarflexion, ankle inversion and ... -
Priming Effects of Female Pheromones on Reproductive Physiology in Gαo Knockout Male Mice
Primer effects are a type of communication, where pheromones affect the bodily functions of other individuals. Primer effects provide benefits for reproduction, as animals can prepare their bodies for mating successfully. ... -
MicroRNAs as diagnostic biomarkers of Parkinson's disease
Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra. It is a heterogeneous disease caused by the complex interactions between genetic and environmental risk ... -
Insights into spinal cord biology and its contributions to adolescent idiopathic scoliosis: From GWAS to animal models
The aim of this thesis was to investigate the relationship between the spinal cord, adolescent idiopathic scoliosis (AIS), biological sex and a transcription factor, LBX1. AIS is a multifactorial gene of unknown aetiology ... -
An investigation into the whole transcriptome in Alzheimer's disease - contribution of coding and non-coding RNA
Alzheimer’s disease (AD) is a chronic neurogenerative disease affecting millions of people worldwide. While significant strides have been made in understanding the aetiology and pathogenesis of AD, current theories cannot ... -
The effect of ageing and BDNF signalling in post-stroke cognition
Every year, millions of people worldwide will have a stroke. For those who survive, many will live on with persistent disability, including cognitive impairments. To better understand the mechanisms underlying cognitive ... -
An investigation to optimise stimulation parameters of Remote Ischaemic Conditioning with digital stimulation
Background: Many ongoing clinical trials are investigating the ability of Remote Ischemic Conditioning (RIC) to limit ischemic injury in major organs such as the heart and brain, focussing on cardiac surgery, myocardial ...