Anatomy
Recent Deposits
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Cognitive Impairment in a Prefrontal Cortex Model of Ischaemia
Every year, millions of people worldwide will have a stroke. For those that survive, many will live with long lasting disabilities, including cognitive impairment. Unfortunately, there are a limited number of preclinical ... -
Balancing Safety and Developmental Potency: Assessing the Effect of Antioxidants and TET on Genomic Imprinting Stability.
Developmental potency represents the ability of undifferentiated cells to undergo transformation into differentiated cells, with specialised functions. The inner cell mass (ICM) of a blastocyst represents the most ... -
Mapping post-stroke brain activation patterns: How do they change over time?
Stroke is a leading cause of death and long-term disability worldwide. Despite decades of research on neuroprotection, only few therapies are currently available to minimise the extent of infarction. As a result, researchers ... -
Investigating the Mechanisms of Prolactin's Role in Maternal Behaviour
Prolactin activity in the medial preoptic area (MPOA) of the hypothalamus has been shown to be essential for the display of maternal behaviours in postpartum female mice. Neuronal outputs from the MPOA that express the ... -
The role of the anterior and ventromedial hypothalamic regions in mediating leptin's effect on fertility
Reproductive function is an energetically demanding process and is therefore tightly regulated by peripheral energy status. This is illustrated by delayed puberty onset and impaired adult reproductive function in individuals ... -
Prolactin receptor expression in the mouse brain
We used a novel knock‐in mouse strain in which Cre recombinase is expressed together with the long isoform of the Prlr using an internal ribosome entry site (IRES). By crossing this Prlr‐IRES‐Cre mouse with a tau green ... -
Evaluating environmental DNA (eDNA) metabarcoding as a method for monitoring biodiversity in marine ecosystems.
Halting current global biodiversity loss is important to maintain ecosystem functioning. To succeed in halting biodiversity loss, information is needed on community composition, abundance of species, and changes in these ... -
Quantifying global CG methylation in regenerative Zebrafish caudal fin and Xenopus tail buds.
Epigenetics is a control mechanism that creates stable alterations in gene expression thatdoes not require underlying changes in DNA sequence. One of the most iconic and prevalent epigenetic mechanisms involves CG methylation, ... -
An investigation in the neuromodulation of olfactory function using non-invasive vagus nerve stimulation
In the existing literature, invasive direct vagus nerve stimulation (VNS) using high frequencies has shown to be effective in modulating the activity of the olfactory bulb in animal models. Under indirect vagus nerve ... -
Nutritional Factors in the Paleoepidemiology of Infectious Disease in the Ancient Atacama Desert
The adoption of agriculture in ancient human groups is thought to have resulted in a general decline in health, as evidenced by an increase in skeletal markers of infectious disease and nutritional stress in post-transitional ... -
Leptin and insulin signaling on midbrain dopamine neurons do not modulate anxiety and depression behaviours
Anxiety is a highly aroused negative emotional state that occurs in response to potential danger, and can be inappropriately intensified due to aberrations in the aversion pathway of mesocorticolimbic dopamine circuitry. ... -
Anatomy of microvenous valves of normal and venous ulcerated lower limbs
Venous disease is a very common disease that affects millions of people worldwide. While some of the factors that cause the development of varicose veins are well understood, the aetiology of venous ulceration is poorly ... -
Agriculture in Northern Chile’s Atacama Desert: Implications for Human Skeletal and Dental Growth of Early Pre-Hispanic Populations
This project tests the theoretical model predicting human health deterioration with the development and intensification of agriculture in northern Chile (Cohen and Armelagos 1984). Research from North America and Europe ... -
Changes in AMPA Receptor Subunit Expression in the Somatosensory Cortex of the Stargazer Mouse Model of Absence Epilepsy
Childhood absence epilepsy (CAE) is the most common early-onset epilepsy accounting for about 10-17% of all paediatric epilepsies. It is a genetic generalized, non-convulsive form of epilepsy characterized by a sudden and ... -
The regulation and function of the transcription factor Lhx9 during mouse limb and urogenital development.
Developmentally important genes often have pleiotropic effects, being involved in and necessary for multiple developmental processes. An example of this is the LIM- homeobox gene, Lhx9, a transcription factor required for ... -
The impact of high and low-intensity transcranial magnetic stimulation on measures of cortical excitability
In recent decades, transcranial magnetic stimulation (TMS) has emerged as one of the most promising techniques for clinical therapies. It has been proposed for use in a wide number of neurophysiological disorders including ... -
Stereological analysis of the normal red nucleus, and the effect of delayed treatment with adult-sourced adipose-derived mesenchymal stem cells on neonatal hypoxic-ischemic brain injury and motor skills, in the rat
The red nucleus (RN) was investigated first to provide important data for the transfer of information through the RN and to learn key stereological methods that were then applied to the stem cell study. Six male rats, and ... -
Lhx9 is required for urogenital ridge development and ovarian function
While there has been extensive research into the differentiation of sexually dimorphic gonads, there is much to learn about the bi-potential structure they arise from, the urogenital ridge (UGR). This gap in knowledge is ... -
Interleukin-6 Signalling in the Murine Adrenal Gland
The adrenal gland is instrumental in the maintenance and restoration of homeostasis. This is mediated in part by catecholamine and glucocorticoid secretion from the adrenal medulla and cortex respectively. The catecholamine ... -
Secreted amyloid precursor protein alpha regulates AMPA receptor synthesis and expression
Amyloid precursor protein, the parent molecule of the neurotoxic amyloid beta protein associated with Alzheimer’s disease, can also liberate the secreted amyloid precursor protein alpha (sAPPα). This molecule facilitates ...