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Characterisation of hypothalamic leptin resistance during pregnancy in the rat
Leptin is primarily an adipose-derived hormone that acts in the hypothalamus to regulate body fat levels by suppressing appetite and increasing metabolic rate. Pregnancy is characterised by increased food intake and fat ...
Anatomical and functional characterization of hypothalamic insulin signaling in the metabolic control of reproductive function in mice
Central insulin signaling plays a key role in regulating the neuroendocrine reproductive axis. Mice exhibiting brain-specific insulin receptor gene (Insr) deletion (NIRKO mice) or diabetic insulin insufficiency display ...
The effect of maternal obesity on neural stem cell proliferation in pre natal mice
Autism Spectrum Disorder (ASD) is a complex neurological condition. It affects approximately 1 in 110 people world wide, with a 4:1 ratio of males to females affected. ASD presents with a wide range of psychological symptoms ...
Cellular Mechanisms of Prolactin Regulation of Oxytocin Neurons in Reproduction
The hormone oxytocin is secreted from nerve terminals of oxytocin magnocellular cells (MNCs) in the posterior pituitary gland and is important in the timing of birth and is essential for milk secretion. Another reproductive ...
Disposing of the Dead: An Investigation into Prehistoric Mortuary Practices During the Neolithic and Bronze Ages at Ban Non Wat, Thailand
Ban Non Wat is a prehistoric mounded site located in the upper Mun Valley of Northeast Thailand. It was excavated over five years under the Origins of the Civilization of Angkor research project, which uncovered 635 human ...
The Human Ileocaecal Junction: An Anatomical Study using Classical and Modern Techniques
Introduction
As a major site of regulation of the physiological unidirectional flow of gastrointestinal content, the human ileocaecal junction (ICJ) is an important structure for the health of the individual. Although ...
Non-Psychotic Traits of Schizophrenia as Abnormalities of Cerebral Asymmetry: Development of a Potential Early Screening Instrument
The main aim of this research is to provide the basis for future development of an early screening instrument to identify individuals who may be at risk of developing schizophrenia (or related disorders). It is based on a ...
Central venous surface anatomy: a critical reappraisal
Background: Surface anatomy is an essential part of safe clinical practice, and a key component of physical examination. Our knowledge of surface anatomy has been primarily derived from cadaver studies, with all their ...
Assessment of genetic variation in the threatened New Zealand sea lion, Phocarctos hookeri, and its association with fitness
The New Zealand sea lion (NZSL) is the rarest sea lion in the world and exists in relative isolation, primarily in New Zealand’s sub-Antarctic islands. Once widespread throughout New Zealand, the species suffered a population ...
TGF-β Superfamily Expression and Related Signalling in Low and High Grade Human Prostate Cancer
Prostate cancer (PCa) is a common malignancy being the second most diagnosed cancer and sixth leading cause of male cancer death worldwide. PCa may present itself in several ways; slow growing and relatively benign, or ...