- OUR Archive Home
- →
- Division of Health Sciences Departments
- →
- Otago School of Medical Sciences
- →
- Microbiology and Immunology
JavaScript is disabled for your browser. Some features of this site may not work without it.
Microbiology and Immunology
Browse by
Recent Deposits
-
(Thesis, Doctor of Philosophy, 2017)From the war on drug resistance, through cancer biology, even to agricultural and environmental protection; there is a huge demand for rapid and effective solutions to infections and diseases. The development of small ...
-
(Thesis, Master of Science, 2017)The anaphase promoting complex (APC/C) is a multi-component ubiquitin ligase complex responsible for targeting cell cycle proteins for degradation. APC/C consists of at least 12 subunits with additional cofactors. Poxvirus ...
-
(Thesis, Doctor of Philosophy, 2017)Tuberculosis (TB) has surpassed human immunodeficiency virus as the world’s deadliest infectious disease. The intradermal TB vaccine, bacille Calmette-Guérin (BCG), prevents disseminated childhood TB yet fails to protect ...
-
(Thesis, Doctor of Philosophy, 2017)Influenza virus continues to pose serious medical and economic challenges to global public health as novel influenza viruses regularly emerge in human population. A universal influenza virus vaccine is not available yet ... -
(Thesis, Doctor of Philosophy, 2016)ATP synthases are multi-subunit membrane-bound enzymes that utilise the energy stored in a transmembrane electrochemical ion gradient to produce ATP, the major energy currency of all living cells. The F-type ATP synthase ...
-
(Thesis, Bachelor of Biomedical Sciences with Honours, 2016)Tuberculosis (TB) is a pulmonary disease caused by Mycobacterium tuberculosis, which killed 1.5 million people in 2014. The current TB vaccine, live attenuated Mycobacterium bovis bacille Calmette Guérin (BCG), effectively ...
-
(Thesis, Doctor of Philosophy, 2016)Worldwide, more than one million people are diagnosed with colorectal cancer (CRC) every year. Analysis of T cell infiltrate into CRC tumours accurately predicts patient prognosis, but the immune response against CRC is ...
-
(Thesis, Master of Medical Laboratory Science, 2016)Shiga-toxigenic Escherichia coli (STEC) and enteropathogenic E. coli (EPEC) are recognised to be significant contributors to intestinal and extra-intestinal disease and infantile diarrhoea worldwide. In New Zealand, STEC ... -
(Thesis, Doctor of Philosophy, 1982)[…] The major objectives of this study were to determine more precisely the degree of relationship of rotaviral isolates from different host species by comparison at the genetic level. Before this could be fully investigated, ... -
(Thesis, Doctor of Philosophy, 2015)Vaccination is used in the prevention of disease around the world. Through activation of T and B cells, and subsequent generation of memory cells, long lasting protection against disease is given. The majority of vaccines ...
-
(Thesis, Doctor of Philosophy, 2015)Human norovirus (HuNoV) causes the majority of acute, non-bacterial endemic gastroenteritis worldwide. Noroviruses belong to the Caliciviridae family and have a positive-sense, single single-stranded, RNA genome of around ... -
(Thesis, Doctor of Philosophy, 2015)Studies have identified breeds of farmed red deer (Cervus elaphus) that express polarised phenotypes for Resilience (R) or Susceptibility (S) to Johne’s disease, following natural infection with Mycobacterium avium subspecies ...
-
(Thesis, Master of Science, 2015)Cancer is a group of diseases characterised by uncontrolled proliferation and metastasis of malignant cells throughout the body which if not treated leads to death. Melanoma is a form of skin cancer that accounts for less ...
-
(Thesis, Bachelor of Biomedical Sciences with Honours, 2015)This study examined the effects of two Orf virus-derived proteins, vIL-10 and VEGF-E, on chronic wounds in horses, to determine if they can improve vascularisation and re-epithelialisation while reducing scarring. -
(Thesis, Doctor of Philosophy, 2015)Nitrogen is an essential component of the bacterial cell and bacteria have developed elaborate regulatory mechanisms used to control the uptake, assimilation and metabolism of nitrogen. In this thesis, I have developed a ... -
(Thesis, Doctor of Philosophy, 2015)The human colon contains about 20 trillion commensal bacteria belonging to about 160 species per human. The mechanisms by which individual species of these bacteria evade host inflammatory immune responses and instead ... -
(Thesis, Doctor of Philosophy, 2015)HPV is a non-lytic virus that infects and replicates within keratinocytes in the skin. Persistent infection with high risk human papillomavirus (HPV) such as HPV type 16 and 18 is associated with cervical cancer. Despite ...
-
(Thesis, Master of Science, 2015)Omega-3 fatty acids (ω-3 FA) are essential to human health. However, the primary source of ω-3 FA are declining fish stocks. A more sustainable alternative is the cultivation of marine bacteria, however, the yields to date ... -
(Thesis, Doctor of Philosophy, 2015)Compounds that target energy generation in many bacterial pathogens are effective inhibitors of growth, however their precise molecular targets and interactions are poorly understood. Type II (non-proton-translocating) ...
-
(Thesis, Doctor of Philosophy, 2015)A large number of viruses are known to produce proteins that interact with pRB. For the most part these are small DNA viruses, such as Adenovirus and Human papilloma virus, which require that the cell be in a replicative ...
