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Microbiology and Immunology

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The Chemokine-binding Proteins Encoded by Bovine Papular Stomatitis Virus and Parapoxvirus of Red Deer in New Zealand: Molecular and Functional Characterization

Sharif, Saeed (Thesis, Doctor of Philosophy, 2017)

Poxviruses are large DNA viruses that infect a wide range of animals including humans. During the course of evolution, these complex viruses have gained an extensive repertoire of immunomodulatory genes to evade host immune ...
N cycling and microbial dynamics in pasture soils

Samad, Md Sainur (Thesis, Doctor of Philosophy, 2017)

Pasture soils are a significant source of the greenhouse gas, nitrous oxide (N2O) and as such they contribute to global warming. It has been reported that N2O is approx. 300 times more potent than carbon dioxide (CO2) as ...
Development of In-vitro Skin Models for Thermal Injury; to Investigate the Impact of Commensal Staphylococcus species on Wound Healing

Fleming, Jodie Sarah Min Lei (Thesis, Master of Science, 2017)

Skin is the largest organ of the body protecting our internal organs from physical injury, microbial invasion and infection. Healthy skin homeostasis relies on the interaction between the skin’s physical properties, its ...
Neutrophil killing of Staphylococcus aureus In Sepsis

Nazari, Shekufah (Thesis, Master of Science, 2017)

Neutrophils form the majority of circulating white blood cells and play a principle role in defending the body against invasions by microorganisms. Neutrophils engulf microorganisms into a phagosome where they kill them ...
The Antiviral Potential of Host Histone Deacetylase 11 during Influenza Virus Infection

Nutsford, Ashley (Thesis, Master of Science, 2017)

Influenza A virus (IAV) continues to have a major impact on global public health by causing regular seasonal epidemics, unpredictable pandemics and zoonotic outbreaks. These events also have significant implications for ...
Fundamental and applied investigations into mycobacterial bioenergetics

Hards, Kiel Jason (Thesis, Doctor of Philosophy, 2017)

From the war on drug resistance, through cancer biology, even to agricultural and environmental protection; there is a huge demand for rapid and effective solutions to infections and diseases. The development of small ...
Examining Inducible Expression of the Poxvirus Anaphase-promoting Complex Regulator (PACR)

Patel, Pramit (Thesis, Master of Science, 2017)

The anaphase promoting complex (APC/C) is a multi-component ubiquitin ligase complex responsible for targeting cell cycle proteins for degradation. APC/C consists of at least 12 subunits with additional cofactors. Poxvirus ...
Cellular Mediators of BCG Vaccine-Induced Protection

Steigler, Pia (Thesis, Doctor of Philosophy, 2017)

Tuberculosis (TB) has surpassed human immunodeficiency virus as the world’s deadliest infectious disease. The intradermal TB vaccine, bacille Calmette-Guérin (BCG), prevents disseminated childhood TB yet fails to protect ...
Identification of the host histone deacetylase 1 and 2 as novel anti-influenza A virus factors

Thevkar Nagesh, Prashanth (Thesis, Doctor of Philosophy, 2017)

Influenza virus continues to pose serious medical and economic challenges to global public health as novel influenza viruses regularly emerge in human population. A universal influenza virus vaccine is not available yet ...
Structure and function of the F-type ATP synthase from Fusobacterium nucleatum

Petri, Jessica (Thesis, Doctor of Philosophy, 2016)

ATP synthases are multi-subunit membrane-bound enzymes that utilise the energy stored in a transmembrane electrochemical ion gradient to produce ATP, the major energy currency of all living cells. The F-type ATP synthase ...
Efficacy of Prototype Vaccines for Prevention of Tuberculosis

Sandford, Sarah (Thesis, Bachelor of Biomedical Sciences with Honours, 2016)

Tuberculosis (TB) is a pulmonary disease caused by Mycobacterium tuberculosis, which killed 1.5 million people in 2014. The current TB vaccine, live attenuated Mycobacterium bovis bacille Calmette Guérin (BCG), effectively ...
Phenotypic and functional suppression of T cells in human colorectal cancer tissue

Taylor, Edward (Thesis, Doctor of Philosophy, 2016)

Worldwide, more than one million people are diagnosed with colorectal cancer (CRC) every year. Analysis of T cell infiltrate into CRC tumours accurately predicts patient prognosis, but the immune response against CRC is ...
Detection of Shiga-toxigenic and enteropathogenic Escherichia coli in diarrhoeic stools

Thomas, Rowan Ryland (Thesis, Master of Medical Laboratory Science, 2016)

Shiga-toxigenic Escherichia coli (STEC) and enteropathogenic E. coli (EPEC) are recognised to be significant contributors to intestinal and extra-intestinal disease and infantile diarrhoea worldwide. In New Zealand, STEC ...
Comparison of human and animal rotavirus isolates

Schroeder, Bryan A. (Thesis, Doctor of Philosophy, 1982)

[…] The major objectives of this study were to determine more precisely the degree of relationship of rotaviral isolates from different host species by comparison at the genetic level. Before this could be fully investigated, ...
Immunisation with chitosan hydrogel generates CD8+ memory T cells protective against tumour challenge

Highton, Andrew John (Thesis, Doctor of Philosophy, 2015)

Vaccination is used in the prevention of disease around the world. Through activation of T and B cells, and subsequent generation of memory cells, long lasting protection against disease is given. The majority of vaccines ...
Murine Norovirus Manipulation of the Cell Cycle

Davies, Colin Thomas Rainsford (Thesis, Doctor of Philosophy, 2015)

Human norovirus (HuNoV) causes the majority of acute, non-bacterial endemic gastroenteritis worldwide. Noroviruses belong to the Caliciviridae family and have a positive-sense, single single-stranded, RNA genome of around ...
Immune Biomarkers to Identify Resilient and Susceptible Johne's Disease Phenotypes in Red Deer (Cervus elaphus)

Brennan, Liam Paul (Thesis, Doctor of Philosophy, 2015)

Studies have identified breeds of farmed red deer (Cervus elaphus) that express polarised phenotypes for Resilience (R) or Susceptibility (S) to Johne’s disease, following natural infection with Mycobacterium avium subspecies ...
Myeloid-derived suppressor cells and their potential role in a therapeutic cancer vaccine

Shirley, Simon (Thesis, Master of Science, 2015)

Cancer is a group of diseases characterised by uncontrolled proliferation and metastasis of malignant cells throughout the body which if not treated leads to death. Melanoma is a form of skin cancer that accounts for less ...
Viral proteins as novel therapeutics in chronic horse wounds.

Wakelin, Kirsty Anne (Thesis, Bachelor of Biomedical Sciences with Honours, 2015)

This study examined the effects of two Orf virus-derived proteins, vIL-10 and VEGF-E, on chronic wounds in horses, to determine if they can improve vascularisation and re-epithelialisation while reducing scarring.
Nitrogen metabolism in Mycobacterium smegmatis

Petridis, Michael (Thesis, Doctor of Philosophy, 2015)

Nitrogen is an essential component of the bacterial cell and bacteria have developed elaborate regulatory mechanisms used to control the uptake, assimilation and metabolism of nitrogen. In this thesis, I have developed a ...