Microbiology and Immunology
Recent Deposits
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Structural and Proteomic Analysis of ΦTE, a Phage Infecting Pectobacterium atrosepticum
Bacteriophages are extremely diverse and are also far more numerous than any other organism on Earth. Despite this diversity, there still remain many unanswered questions regarding their structures, what (and how) forces ... -
Blimp-1+ regulatory T cells in human colorectal cancer
Analysis of tumour infiltrating immune cells in colorectal cancer (CRC) is superior to the current staging at predicting disease-free survival. The Immunoscore has been proposed as a way to use CD3+ and CD8+ T cell infiltrates ... -
Investigating resistance in Enterococcus faecalis against the new antibiotic teixobactin
The rapid rise and spread of multi-drug resistant (MDR) pathogens has become a daunting reality for many countries world-wide driving the need for new antimicrobials with novel targets. Enterococci, a natural inhabitant ... -
The human kinases mTOR, PKC-α, and their substrate Filamin A promote infection of human cells by Listeria monocytogenes
The bacterium Listeria monocytogenes is a food borne intracellular pathogen capable of causing gastroenteritis, abortions, or meningitis with a high mortality rate. Listeria is a facultative intracellular pathogen that ... -
Role for Host Exocytosis in Entry of the Bacterial Pathogen Listeria monocytogenes into Human Cells
Listeria monocytogenes (Lm) is a Gram-positive bacterium responsible for gastroenteritis, meningitis, and abortion in pregnant women. This intracellular pathogen is able to induce its internalization into host mammalian ... -
Role of host Arf GTPases and the scaffolding protein Tuba in the infection of human cells by bacterial pathogen Listeria monocytogenes
The gram-positive bacterium Listeria monocytogenes is an important cause of foodborne illnesses resulting in gastroenteritis, meningitis, or abortion. Listeria is a facultative intracellular pathogen that is able to induce ... -
Tumour Extracellular Vesicles in Cancer Metastasis & Thrombosis
Tumour cells release lipid particles known as extracellular vesicles (EV) that contribute to cancer metastasis, to the immune response, and to thrombosis. There are many types of identified EV, and most live tumour cells ... -
Characterising a large population of langerin+, MHC-II+ cells in mouse skin wounds
Developing a thorough understanding of wound healing is crucial given the importance of the skin and the many challenges medical professionals face when it is damaged. The immune system is very involved in the healing ... -
Investigating the Site of Innate Lymphoid Cell Division Following BCG Vaccination
Tuberculosis (TB) is the most deadly infectious disease worldwide, killing 1.4 million people each year. Efforts to control the spread of this disease through antibiotic treatments and a century-old preventative vaccine, ... -
T cell signalling in patients with colorectal cancer
T lymphocytes (T cells) are essential for mediating an effector response against tumours. High infiltrates of T cells in the tumour from colorectal cancer (CRC) patients are associated with positive patient outcomes, ... -
Activated macrophages in human colorectal cancer
Unlike in other cancers, a high infiltration of macrophages in colorectal cancer has been associated with improved patient prognosis. However, controversy lies over the exact effect macrophages have in altering colorectal ... -
Regulation of Antimicrobial Resistance in Enterococcus faecalis
The inappropriate use and overuse of antimicrobials in both clinical and agricultural settings, has led to the rapid emergence and spread of antimicrobial resistance (AMR). Key to combatting AMR will be obtaining a detailed ... -
The Chemokine-binding Proteins Encoded by Bovine Papular Stomatitis Virus and Parapoxvirus of Red Deer in New Zealand: Molecular and Functional Characterization
Poxviruses are large DNA viruses that infect a wide range of animals including humans. During the course of evolution, these complex viruses have gained an extensive repertoire of immunomodulatory genes to evade host immune ... -
N cycling and microbial dynamics in pasture soils
Pasture soils are a significant source of the greenhouse gas, nitrous oxide (N2O) and as such they contribute to global warming. It has been reported that N2O is approx. 300 times more potent than carbon dioxide (CO2) as ... -
Development of In-vitro Skin Models for Thermal Injury; to Investigate the Impact of Commensal Staphylococcus species on Wound Healing
Skin is the largest organ of the body protecting our internal organs from physical injury, microbial invasion and infection. Healthy skin homeostasis relies on the interaction between the skin’s physical properties, its ... -
Neutrophil killing of Staphylococcus aureus In Sepsis
Neutrophils form the majority of circulating white blood cells and play a principle role in defending the body against invasions by microorganisms. Neutrophils engulf microorganisms into a phagosome where they kill them ... -
The Antiviral Potential of Host Histone Deacetylase 11 during Influenza Virus Infection
Influenza A virus (IAV) continues to have a major impact on global public health by causing regular seasonal epidemics, unpredictable pandemics and zoonotic outbreaks. These events also have significant implications for ... -
Fundamental and applied investigations into mycobacterial bioenergetics
From the war on drug resistance, through cancer biology, even to agricultural and environmental protection; there is a huge demand for rapid and effective solutions to infections and diseases. The development of small ... -
Examining Inducible Expression of the Poxvirus Anaphase-promoting Complex Regulator (PACR)
The anaphase promoting complex (APC/C) is a multi-component ubiquitin ligase complex responsible for targeting cell cycle proteins for degradation. APC/C consists of at least 12 subunits with additional cofactors. Poxvirus ... -
Cellular Mediators of BCG Vaccine-Induced Protection
Tuberculosis (TB) has surpassed human immunodeficiency virus as the world’s deadliest infectious disease. The intradermal TB vaccine, bacille Calmette-Guérin (BCG), prevents disseminated childhood TB yet fails to protect ...