Microbiology and Immunology
Recent Deposits
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Early innate immunity against mycobacterial infection
Infection by Mycobacterium tuberculosis is not consistently prevented by the only licensed vaccine, bacillus Calmette-Guérin (BCG). It is widely believed that adaptive immune memory confers protection against tuberculosis ... -
Essentiality of succinate metabolism in Mycobacterium tuberculosis
New drugs are urgently required to combat the tuberculosis epidemic that claims over 1.5 million lives annually. The identification of bedaquiline (BDQ) as an inhibitor of the mycobacterial F1Fo ATP synthase and its ... -
Decoding the dual target antiactivator QseM
Regulation of transfer of the symbiosis island of Mesorhizobium japonicum strain R7A, ICEMlSymR7A, is tightly controlled by a complex multi-component regulatory system. The master antiactivator of this system is QseM, which ... -
Some microbiological aspects of the short eared European hedgehog, erinaceus europaeus, in New Zealand
Among English farmers and game wardens, a large body of folklore on hedgehogs has existed for centuries. The first scientific description of these mammals was contained in Barrett-Hamilton’s ‘A History of the British ... -
A proteomic and molecular approach to decipher the repertoire of protein modifications during influenza A virus infection
Influenza virus is an important human respiratory pathogen that continues to have a major impact on global public health. The ever-evolving nature of influenza virus has restricted the development of a universal vaccine ... -
Prognostic Molecular Markers of Response to Radiotherapy in Rectal Cancer
Colorectal cancer (CRC) is the second most deadly cancer globally, and 30% of these cancers occur in the rectum. The primary treatment for CRC is surgery, often radiotherapy with adjuvant chemotherapy is used before or ... -
Molecular basis for antimalarial resistance and erythrocyte invasion in Plasmodim vivax using Plasmodium cynomolgi as a model.
Malaria is a life-threatening disease caused by Plasmodium spp. parasites. Although Plasmodium falciparum is the deadliest form of malaria, Plasmodium vivax is the most globally widespread, with 40 % of the world’s population ... -
Genetic manipulation of Plasmodium cynomolgi as a model for investigating Plasmodium vivax drug resistance
Plasmodium vivax is the most widely distributed cause of human malaria, and thought to be the most difficult to diagnose and treat. Until recently this species has largely been neglected compared to the most significant ... -
Strategies to enhance CAR T cell function in solid tumours utilising coding and non-coding genes
Cancer immunotherapy has emerged as an effective treatment to provide benefits to cancer patients. One of the main treatment modalities of cancer immunotherapy is the adoptive transfer of T cells with genetically engineered ... -
Mechanisms of bactericidal action and β-lactam synergy by the zinc ionophore PBT2
The emergence and global spread of antimicrobial resistance (AMR) is an increasingly serious threat to human and veterinary medicine. Driven by the misuse and overuse of antibiotics, resistance to our antibiotic armoury ... -
High Dimensional Analysis of Myeloid Cells in Colorectal Cancer
Development of immune therapy requires an in-depth knowledge of immune cells, how they act in a tumour, and how they can be manipulated. Colorectal cancer (CRC) patients have shown less favourable outcomes with immune ... -
Characterization of the Potential Antiviral Activity of Peptides and Peptoids against Influenza A Virus and Severe Acute Respiratory Syndrome Coronavirus 2
Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) has caused worldwide panic during 2020. To date SARS-CoV-2, the virus causing COVID-19, has caused 1 million deaths and infected over 35 million people in under ... -
Tumour Necrosis Factor Signalling Heterogeneity in Inflammatory Bowel Diseases
Inflammatory bowel disease (IBD) is chronic, heterogeneous diseases characterised by excess inflammation in the gastrointestinal system and a dysfunctional mucosal immune response. Tumour necrosis factor (TNF) is a ... -
Mucosal-associated invariant T cell regulation by bacterial signalling and immunometabolism
Mucosal-associated invariant T (MAIT) cells are a subset of antibacterial innate-like T cells that are localised to mucosal surfaces. MAIT cells are characterised by the expression of a semi-invariant T cell receptor, ... -
Enhancing the persistence and memory of CAR T cells
CAR T cell therapy has revolutionized cancer treatment, but has also provided an opportunity for treating chronic viral infections such as HIV, HBV, and HCV. Despite the profound outcomes in the treatment of hematological ... -
Investigating the invasion biology of Plasmodium vivax using its sister species, Plasmodium cynomolgi
The erythrocytic stages of the relapsing human malaria parasite, Plasmodium vivax (P. vivax), preferentially invades immature CD71+ reticulocytes. This strict tropism for nascent reticulocytes is the primary reason for the ... -
Thermal Selection of Seneca Valley Virus Gives Rise to a Novel Thermostable Mutant
This project aimed to improve the stability of the novel oncolytic virus, Seneca Valley virus (SVV). This was with the overarching goal of determining the residues and mutations thereof within the viral capsid that are ... -
Crohn's disease: an in vitro analysis of T lymphocyte function and response to commensal microbes
Inflammatory bowel disease is a chronic, relapsing inflammation of the intestine. Approximately 0.5% of the western world is estimated to suffer from the disease. Crohn’s disease, a type of inflammatory bowel disease, ... -
ORFV virus manipulation of type I interferon expression
Orf virus (ORFV) is the type species of the Parapoxvirus genus that belongs to the Poxviridae family. ORFV is an epitheliotropic virus inducing cutaneous pustular skin lesions in sheep and goats and is transmissible to ... -
Bidirectional promoters for the use of CAR T cell therapy
Cancer is currently a leading cause of death in the world, with 9.6 million deaths in 2018 alone according to the Global Cancer Observatory (GLOBOCAN). Conventional methods such as surgery, chemotherapy, and radiotherapy, ...