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The Effect of Orf Virus Infection on the IFN Stimulated JAK/STAT Signalling Pathway
Orf Virus (ORFV) is a large, 134 kbp dsDNA virus that is the type species of the Parapoxvirus genus. ORFV infections are epitheliotropic resulting in lesions of the skin. The natural host range of the virus consists of ...
The Role of Dendritic Cell Subsets in the Early Immune Response to Mycobacterial Infection
The early immune response to tuberculosis (TB) is poorly understood. However, recent evidence has shown that dendritic cells (DC) are important for both control of bacterial growth and for activating adaptive immunity. DC ...
It all starts in the gut: The intestinal immune cell infiltrate in inflammatory bowel disease and ankylosing spondylitis
Inflammatory Bowel Disease (IBD) and Ankylosing Spondylitis (AS) have epidemiological, symptomatic and genetic overlap. Many people with IBD develop AS and vice versa, and both groups of patients exhibit pathological ...
CRP and the regulation of the Type I-F CRISPR-Cas system in Pectobacterium atrosepticum
Throughout the billions of years of evolution bacteria have been preyed upon by nucleic acids of extra-chromosomal origin. To combat these potential threats, bacteria have evolved a plethora of defensive mechanisms, one ...
Wnt signalling influences T cell phenotype in a novel intestinal immune system model
Inflammatory bowel disease (IBD) is a collective term for inflammatory conditions that affect the gastro-intestinal tract. These conditions feature a multifactorial etiology: an interplay of genetics, environmental exposures, ...
Cell Cycle Regulation by Poxviruses
The parapoxvirus, orf virus (OV) encodes a RING-H2 protein that is a homologue of subunit 11 (APC11) of the Anaphase Promoting Complex or Cyclosome (APC/C). APC/C is a ubiquitin ligase and through this activity it functions ...
Exploring the Application of Streptococcus salivarius Dextranase to Enhance the Permeability of Biofilms to Anti-Mutans Streptococcus Bacteriocins
Dental caries is the most prevalent infectious disease of humans and can ultimately result in destruction of affected teeth. Recent studies indicate that there is a resurgence of dental caries occurrence in both developing ...
Murine Norovirus Manipulation of the Immune Response
Human norovirus is a significant human pathogen that causes morbidity and mortality worldwide. Noroviruses are a member of the Caliciviridae family of positive sense, single-stranded RNA viruses. The inability to study ...
Novel Methods for the Rapid Identification and Susceptibility Testing of Blood Culture Isolates
The increasing emergence of antimicrobial resistance, such as that mediated by extended-spectrum β-lactamase (ESBL)-producing gram-negative bacteria, make it more likely that patients with sepsis and bloodstream infections ...
Functional analysis of the Orf virus ORF116 gene: a potential modulator of the interferon response
Orf virus (OV) is the type species of the Parapoxvirus genus. Like other poxviruses, genetic and functional studies have revealed that it has immunomodulatory genes that manipulate the innate immune response, often during ...