Studies have identified breeds of farmed red deer (Cervus elaphus) that express polarised phenotypes for Resilience (R) or Susceptibility (S) to Johne’s disease, following natural infection with Mycobacterium avium subspecies ...

Cancer is a group of diseases characterised by uncontrolled proliferation and metastasis of malignant cells throughout the body which if not treated leads to death. Melanoma is a form of skin cancer that accounts for less ...

HPV is a non-lytic virus that infects and replicates within keratinocytes in the skin. Persistent infection with high risk human papillomavirus (HPV) such as HPV type 16 and 18 is associated with cervical cancer. Despite ...

Compounds that target energy generation in many bacterial pathogens are effective inhibitors of growth, however their precise molecular targets and interactions are poorly understood. Type II (non-proton-translocating) ...

The ankyrin (ANK) repeat was named after the cytoskeletal protein ankyrin and is found in a wide range of eukaryotic and bacterial proteins where it mediates protein-protein interactions. Viruses, especially the Poxviridae ...

A large number of viruses are known to produce proteins that interact with pRB. For the most part these are small DNA viruses, such as Adenovirus and Human papilloma virus, which require that the cell be in a replicative ...

Vaccination is used in the prevention of disease around the world. Through activation of T and B cells, and subsequent generation of memory cells, long lasting protection against disease is given. The majority of vaccines ...

Wounded skin, in patients with underlying disease, can become inflamed and unable to heal (1). The economic burden of chronic wounds is significant and expected to rise substantially in the future. Current treatments are ...