The human colon contains about 20 trillion commensal bacteria belonging to about 160 species per human. The mechanisms by which individual species of these bacteria evade host inflammatory immune responses and instead ...

Virus-like particles (VLP), such as the rabbit haemorrhagic disease virus (RHDV) VLP, can be utilised as vectors for the delivery of heterologous antigens to the immune system. Model tumour antigens, such as gp33 and ...

This study examined the effects of two Orf virus-derived proteins, vIL-10 and VEGF-E, on chronic wounds in horses, to determine if they can improve vascularisation and re-epithelialisation while reducing scarring.

Human norovirus (HuNoV) causes the majority of acute, non-bacterial endemic gastroenteritis worldwide. Noroviruses belong to the Caliciviridae family and have a positive-sense, single single-stranded, RNA genome of around ...

Nitrogen is an essential component of the bacterial cell and bacteria have developed elaborate regulatory mechanisms used to control the uptake, assimilation and metabolism of nitrogen. In this thesis, I have developed a ...

Omega-3 fatty acids (ω-3 FA) are essential to human health. However, the primary source of ω-3 FA are declining fish stocks. A more sustainable alternative is the cultivation of marine bacteria, however, the yields to date ...

Quorum Sensing (QS) is a system used by bacteria to coordinate gene expression in response to population density using secreted diffusible signalling molecules, known as autoinducers. Many QS systems are similar to the ...

Exosomes are lipid bound nanovesicles that are formed via the inward budding of the endosomal membrane, then released upon fusion of the endosomal limiting membrane with the plasma membrane. The majority of exosome studies ...

The establishment of a successful symbiotic relationship between legumes and rhizobia requires complex molecular communication between the two partners. Rhizobial exopolysaccharide (EPS) has been implicated as a signalling ...

Biodiesels are increasing in popularity as prices of petroleum have increased over the past two decades and triacylglycerols (TAG) are an attractive alternative as a feedstock to produce biodiesel. Rhodococcus opacus PD630 ...