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Exclusive enteral nutrition therapy reduces Clostridia flagellins within the Crohn’s disease gut microbiome
Crohn’s disease is a highly prevalent form of inflammatory bowel disease, with rapidly increasing incidence both within New Zealand, and around the world. Although Crohn’s disease aetiology is poorly understood, it has ...
Understanding antimicrobial and antiseptic resistance relationships in Staphylococcus aureus
Staphylococcus aureus is an opportunistic pathogen that causes skin infections, bacteraemia, and endocarditis in humans. In New Zealand, the common lineage of S. aureus is the ST1 lineage which harbours a fusidic acid ...
Investigations into the roles of two flavoproteins in mycobacterial physiology
Members of the genus Mycobacterium contain species that are adapted to thrive under a wide variety of environmental conditions. A key factor in the life cycle of mycobacteria is their ability to persist in the absence of ...
Understanding the genetic basis for competitive nodule formation by clover rhizobia
Clovers enter a symbiotic relationship with particular rhizobia through a highly specific and complex signal exchange culminating in the formation of nitrogen-fixing root nodules. Legumes exude flavonoids that are perceived ...
Characterisation of genes involved in exopolysaccharide biosynthesis and transport in the Mesorhizobium loti strain R7A
Rhizobia are bacteria that are important in fixing gaseous nitrogen into a plant-available form via a symbiotic interaction with leguminous plants. In order for this to occur, the legume and the rhizobia must communicate ...
Developing Plasmodium cynomolgi culture as a model to investigate antimalarial effects on Plasmodium vivax
The ability to culture pathogenic organisms enables researchers to understand the biology of the organism which aids in the development of vaccines and drugs. Hence the establishment of the protocol for the in vitro ...
Generation of FMC63 scFv specific anti-idiotype antibodies for quality control of anti-CD19 CAR T cell trials
Chimeric antigen receptor (CAR) T cell therapy is an emerging form of immunotherapy that has revolutionised the treatment of some cancers. This is especially true for relapsed and refractory (r/r) lymphoma where it has ...
Growth Inhibition of Mycobacteria by Innate Lymphoid Cells
Tuberculosis (TB) is a lung disease caused by Mycobacterium tuberculosis (Mtb), which was responsible for 1.6 million deaths in 2017. The only vaccine against TB; bacille Calmette Guérin (BCG), protects against miliary and ...