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Phenotypic and functional suppression of T cells in human colorectal cancer tissue
Worldwide, more than one million people are diagnosed with colorectal cancer (CRC) every year. Analysis of T cell infiltrate into CRC tumours accurately predicts patient prognosis, but the immune response against CRC is ...
Efficacy of Prototype Vaccines for Prevention of Tuberculosis
Tuberculosis (TB) is a pulmonary disease caused by Mycobacterium tuberculosis, which killed 1.5 million people in 2014. The current TB vaccine, live attenuated Mycobacterium bovis bacille Calmette Guérin (BCG), effectively ...
Structure and function of the F-type ATP synthase from Fusobacterium nucleatum
ATP synthases are multi-subunit membrane-bound enzymes that utilise the energy stored in a transmembrane electrochemical ion gradient to produce ATP, the major energy currency of all living cells. The F-type ATP synthase ...