Poxviruses are large DNA viruses that infect a wide range of animals including humans. During the course of evolution, these complex viruses have gained an extensive repertoire of immunomodulatory genes to evade host immune ...

The anaphase promoting complex (APC/C) is a multi-component ubiquitin ligase complex responsible for targeting cell cycle proteins for degradation. APC/C consists of at least 12 subunits with additional cofactors. Poxvirus ...

From the war on drug resistance, through cancer biology, even to agricultural and environmental protection; there is a huge demand for rapid and effective solutions to infections and diseases. The development of small ...

Developing a thorough understanding of wound healing is crucial given the importance of the skin and the many challenges medical professionals face when it is damaged. The immune system is very involved in the healing ...

Tuberculosis (TB) is the most deadly infectious disease worldwide, killing 1.4 million people each year. Efforts to control the spread of this disease through antibiotic treatments and a century-old preventative vaccine, ...

Rabbit haemorrhagic disease virus (RHDV) is a pathogenic member of the Caliciviridae family. The Czech v351 isolate of RHDV is used in Australia and New Zealand as a biological control agent for rabbits, which are an ...

T lymphocytes (T cells) are essential for mediating an effector response against tumours. High infiltrates of T cells in the tumour from colorectal cancer (CRC) patients are associated with positive patient outcomes, ...

The inappropriate use and overuse of antimicrobials in both clinical and agricultural settings, has led to the rapid emergence and spread of antimicrobial resistance (AMR). Key to combatting AMR will be obtaining a detailed ...

Tuberculosis (TB) has surpassed human immunodeficiency virus as the world’s deadliest infectious disease. The intradermal TB vaccine, bacille Calmette-Guérin (BCG), prevents disseminated childhood TB yet fails to protect ...

Unlike in other cancers, a high infiltration of macrophages in colorectal cancer has been associated with improved patient prognosis. However, controversy lies over the exact effect macrophages have in altering colorectal ...