Neonatal necrotising enterocolitis (NEC) is one of the most devastating diseases affecting new born premature infants [5]. Globally it affects 1-5% of all neonatal intensive care admissions and is a leading cause of neonatal ...

The human colon contains about 20 trillion commensal bacteria belonging to about 160 species per human. The mechanisms by which individual species of these bacteria evade host inflammatory immune responses and instead ...

A chitosan/dextran-based (CD) hydrogel has been developed as a post-surgical aid for endoscopic sinus surgery, and has been successful in preventing adhesion formation in human and animal trials. Interest in extending the ...

During the course of this thesis factors mediating successful oral vaccination with lipidencapsulated Mycobacterium bovis BCG were examined. Mice were fed 2x10E07 CFU BCG encapsulated into a lipid matrix to prevent destruction ...

Virus-like particles (VLP), such as the rabbit haemorrhagic disease virus (RHDV) VLP, can be utilised as vectors for the delivery of heterologous antigens to the immune system. Model tumour antigens, such as gp33 and ...

Natural killer (NK) cells were first identified by their ability to kill tumour or virally infected cells without prior sensitization. In spite of this, the actual role of NK cells in tumour immunotherapy remains controversial. ...

One contentious method by which bacteria deal with a maladapted situation is what has been coined ‘adaptive’, ‘directed’ or ‘stress induced-mutation’. This involves mutants that compensate for some form of sub-lethal stress ...

Dendritic cell (DC) immunotherapy is a promising treatment for cancer. Despite now being used in the clinic, the role and mechanisms of lymphocyte subsets stimulated by DC immunotherapy are not completely understood. ...

This study examined the effects of two Orf virus-derived proteins, vIL-10 and VEGF-E, on chronic wounds in horses, to determine if they can improve vascularisation and re-epithelialisation while reducing scarring.

Human norovirus (HuNoV) causes the majority of acute, non-bacterial endemic gastroenteritis worldwide. Noroviruses belong to the Caliciviridae family and have a positive-sense, single single-stranded, RNA genome of around ...