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Blimp-1+ regulatory T cells in human colorectal cancer
Analysis of tumour infiltrating immune cells in colorectal cancer (CRC) is superior to the current staging at predicting disease-free survival. The Immunoscore has been proposed as a way to use CD3+ and CD8+ T cell infiltrates ...
Structural and Proteomic Analysis of ΦTE, a Phage Infecting Pectobacterium atrosepticum
Bacteriophages are extremely diverse and are also far more numerous than any other organism on Earth. Despite this diversity, there still remain many unanswered questions regarding their structures, what (and how) forces ...
Investigating cellular remodelling events induced by the oncolytic Seneca Valley Virus
Cancer is a worldwide problem affecting millions of people. Typical cancer treatments are often very toxic and have a range of negative side effects. A new field of cancer research that may provide new cancer therapies is ...
Investigating resistance in Enterococcus faecalis against the new antibiotic teixobactin
The rapid rise and spread of multi-drug resistant (MDR) pathogens has become a daunting reality for many countries world-wide driving the need for new antimicrobials with novel targets. Enterococci, a natural inhabitant ...
Modulating the immune response to colorectal cancer in mice using a chitosan gel vaccine
Vaccines modulate the host’s anti-tumour immune response and represent an area of emerging immunotherapy research for the treatment of cancer, including colorectal cancer (CRC). Murine subcutaneous (SC) injections of tumour ...
The human kinases mTOR, PKC-α, and their substrate Filamin A promote infection of human cells by Listeria monocytogenes
The bacterium Listeria monocytogenes is a food borne intracellular pathogen capable of causing gastroenteritis, abortions, or meningitis with a high mortality rate. Listeria is a facultative intracellular pathogen that ...
Role of host Arf GTPases and the scaffolding protein Tuba in the infection of human cells by bacterial pathogen Listeria monocytogenes
The gram-positive bacterium Listeria monocytogenes is an important cause of foodborne illnesses resulting in gastroenteritis, meningitis, or abortion. Listeria is a facultative intracellular pathogen that is able to induce ...
Role for Host Exocytosis in Entry of the Bacterial Pathogen Listeria monocytogenes into Human Cells
Listeria monocytogenes (Lm) is a Gram-positive bacterium responsible for gastroenteritis, meningitis, and abortion in pregnant women. This intracellular pathogen is able to induce its internalization into host mammalian ...
MR1 surface expression on primary blood cells and their role in mucosal associated invariant T (MAIT) cell activation
Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes that bridge the innate and adaptive immune systems to provide rapid effector responses against a broad range of bacteria. MAIT cells are characterised ...
Identification of AH1-specific T cells in a mouse model of colorectal cancer
Colorectal cancer (CRC) causes approximately 1.4 million new cases of disease and 700,000 deaths worldwide annually. To overcome limitations of studying CRC in humans, mouse models are used to test therapeutics such as ...