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The Effect of Orf Virus Infection on the IFN Stimulated JAK/STAT Signalling Pathway
Orf Virus (ORFV) is a large, 134 kbp dsDNA virus that is the type species of the Parapoxvirus genus. ORFV infections are epitheliotropic resulting in lesions of the skin. The natural host range of the virus consists of ...
Regulation of E-cadherin by Human Papillomavirus type 16 E6
The primary risk factor for the development of cervical cancer is a persistent infection with certain high-risk human papillomavirus (HPV) types such as 16 and 18. The ability of these viruses to cause such persistent ...
Toxin-Antitoxin Systems of Mycobacterium smegmatis
The genome of Mycobacterium smegmatis contains three putative toxin-antitoxin (TA) systems. The vapBC system has been characterized, but the remaining two TA systems, belonging to the mazEF and phd/doc family have not been ...
Immune Biomarkers to Identify Resilient and Susceptible Johne's Disease Phenotypes in Red Deer (Cervus elaphus)
Studies have identified breeds of farmed red deer (Cervus elaphus) that express polarised phenotypes for Resilience (R) or Susceptibility (S) to Johne’s disease, following natural infection with Mycobacterium avium subspecies ...
Myeloid-derived suppressor cells and their potential role in a therapeutic cancer vaccine
Cancer is a group of diseases characterised by uncontrolled proliferation and metastasis of malignant cells throughout the body which if not treated leads to death. Melanoma is a form of skin cancer that accounts for less ...
The Role of Dendritic Cell Subsets in the Early Immune Response to Mycobacterial Infection
The early immune response to tuberculosis (TB) is poorly understood. However, recent evidence has shown that dendritic cells (DC) are important for both control of bacterial growth and for activating adaptive immunity. DC ...
It all starts in the gut: The intestinal immune cell infiltrate in inflammatory bowel disease and ankylosing spondylitis
Inflammatory Bowel Disease (IBD) and Ankylosing Spondylitis (AS) have epidemiological, symptomatic and genetic overlap. Many people with IBD develop AS and vice versa, and both groups of patients exhibit pathological ...
Human Papillomavirus Type 16 E6 Regulation Of Human Adhesion Protein, E-cadherin
HPV is a non-lytic virus that infects and replicates within keratinocytes in the skin. Persistent infection with high risk human papillomavirus (HPV) such as HPV type 16 and 18 is associated with cervical cancer. Despite ...
CRP and the regulation of the Type I-F CRISPR-Cas system in Pectobacterium atrosepticum
Throughout the billions of years of evolution bacteria have been preyed upon by nucleic acids of extra-chromosomal origin. To combat these potential threats, bacteria have evolved a plethora of defensive mechanisms, one ...
Wnt signalling influences T cell phenotype in a novel intestinal immune system model
Inflammatory bowel disease (IBD) is a collective term for inflammatory conditions that affect the gastro-intestinal tract. These conditions feature a multifactorial etiology: an interplay of genetics, environmental exposures, ...