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Cell Cycle Regulation by Poxviruses
The parapoxvirus, orf virus (OV) encodes a RING-H2 protein that is a homologue of subunit 11 (APC11) of the Anaphase Promoting Complex or Cyclosome (APC/C). APC/C is a ubiquitin ligase and through this activity it functions ...
Exploring the Application of Streptococcus salivarius Dextranase to Enhance the Permeability of Biofilms to Anti-Mutans Streptococcus Bacteriocins
Dental caries is the most prevalent infectious disease of humans and can ultimately result in destruction of affected teeth. Recent studies indicate that there is a resurgence of dental caries occurrence in both developing ...
Phenotypic and functional characterisation of human macrophages – A potential role for gut resident macrophages in colorectal cancer.
High infiltration of macrophages in colorectal cancer is associated with improved patient prognosis. This association is the opposite of what is observed in other cancers, however, we are yet to understand why. Previous ...
Investigation of the functional link between abortive infection and toxin-antitoxin systems
Bacteria are constantly faced by phage predation and various environmental stresses. In response, bacteria have amassed diverse genetic systems enabling their survival in ecological niches. Abortive infection (Abi) systems ...
Regulation of the conserved hypothetical operon sdhEygfX and its control of cellular processes
Serratia sp. ATCC 39006 (Serratia 39006) is a Gram-negative enterobacterium that produces a number of secondary metabolites including the red-pigmented antibiotic prodigiosin (pig). Although the physiological role of pig ...
The molecular basis for mobility of HAI2 in Pectobacterium atrosepticum
Horizontally acquired island 2 (HAI2), one of seventeen putative HAIs identified on the chromosome of Pba SCRI1043, encodes an important phytotoxin, coronafacic acid (CFA), that is a major virulence determinant required ...
Characterisation of Bacitracin Stress Response and Undecaprenyl pyrophosphate phosphatase in Enterococcus faecalis
Bacitracin is a mixture of closely related polypeptide antibiotics and is widely used as a topical antibiotic in humans and extensively for prophylaxis and therapy in food animals. Enterococcus faecalis is a microorganism ...
Sodium Channel Blocking Activity in Coliforms
Necrotizing enterocolitis (NEC) is a devastating disease that mainly affects low birth-weight, preterm neonates. The disease is characterized by necrotizing injury to the intestine that requires antibiotic treatment and, ...
Characterisation of Bacterial Type II NADH Dehydrogenase (NDH-2)
Compounds that target energy generation in many bacterial pathogens are effective inhibitors of growth, however their precise molecular targets and interactions are poorly understood. Type II (non-proton-translocating) ...
Inducing Anti-Tumor Immune Responses with Antigen Conjugated Virus-Like Particles
Virus-like particles (VLP) have been shown to be useful nanoscale platforms in a diverse range of applications including their use as vaccines. They can act as vehicles for the delivery of heterologous antigens to the ...