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Understanding the genetic basis for competitive nodule formation by clover rhizobia
Clovers enter a symbiotic relationship with particular rhizobia through a highly specific and complex signal exchange culminating in the formation of nitrogen-fixing root nodules. Legumes exude flavonoids that are perceived ...
Characterisation of genes involved in exopolysaccharide biosynthesis and transport in the Mesorhizobium loti strain R7A
Rhizobia are bacteria that are important in fixing gaseous nitrogen into a plant-available form via a symbiotic interaction with leguminous plants. In order for this to occur, the legume and the rhizobia must communicate ...
BCG impact on Innate Lymphoid Cells: Determining the Site of Proliferation
Tuberculosis (TB) is an infectious lung disease that is a major cause of mortality, causing an estimated 1.7 million deaths globally per year. The current prophylactic vaccine used against TB, bacille Calmette Guérin (BCG), ...
Developing Plasmodium cynomolgi culture as a model to investigate antimalarial effects on Plasmodium vivax
The ability to culture pathogenic organisms enables researchers to understand the biology of the organism which aids in the development of vaccines and drugs. Hence the establishment of the protocol for the in vitro ...
The antiviral mechanism and viral antagonism of host histone deacetylase 4 in influenza A virus infection
Influenza virus continues to be an important global pathogen which poses serious health and economic challenges. Influenza virus causes regular seasonal epidemics, intermittent and unpredictable pandemics and deadly zoonotic ...
Generation of FMC63 scFv specific anti-idiotype antibodies for quality control of anti-CD19 CAR T cell trials
Chimeric antigen receptor (CAR) T cell therapy is an emerging form of immunotherapy that has revolutionised the treatment of some cancers. This is especially true for relapsed and refractory (r/r) lymphoma where it has ...
Neutrophil killing of Staphylococcus aureus In Sepsis
Neutrophils form the majority of circulating white blood cells and play a principle role in defending the body against invasions by microorganisms. Neutrophils engulf microorganisms into a phagosome where they kill them ...
Efficacy of B16OVA Tumour Cell Lysate Conjugated to Rabbit Haemorrhagic Disease Virus Virus-Like Particles as an Anti-Tumour Vaccine
By presenting antigen to T cells dendritic cells (DC) carry out a central role in the activation of T cell mediated immunity to cancer. Tumour cell lysate (TL) as a source of tumour antigens offers the advantage over single, ...
Development of In-vitro Skin Models for Thermal Injury; to Investigate the Impact of Commensal Staphylococcus species on Wound Healing
Skin is the largest organ of the body protecting our internal organs from physical injury, microbial invasion and infection. Healthy skin homeostasis relies on the interaction between the skin’s physical properties, its ...
N cycling and microbial dynamics in pasture soils
Pasture soils are a significant source of the greenhouse gas, nitrous oxide (N2O) and as such they contribute to global warming. It has been reported that N2O is approx. 300 times more potent than carbon dioxide (CO2) as ...