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Investigating resistance in Enterococcus faecalis against the new antibiotic teixobactin
The rapid rise and spread of multi-drug resistant (MDR) pathogens has become a daunting reality for many countries world-wide driving the need for new antimicrobials with novel targets. Enterococci, a natural inhabitant ...
RHDV VLP Mediated Delivery of α-Galactosylceramide for Immunotherapy
The immune system has the potential to detect and destroy tumour cells, however naturally occurring anti-tumour immunity is not always capable of controlling tumour growth. Immunotherapy can harness the anti-tumour function ...
Functional analysis of the Orf virus ORF116 gene: a potential modulator of the interferon response
Orf virus (OV) is the type species of the Parapoxvirus genus. Like other poxviruses, genetic and functional studies have revealed that it has immunomodulatory genes that manipulate the innate immune response, often during ...
Human papillomavirus type 16 oncoproteins as immune modulators and immune targets
Human papillomavirus (HPV) is the primary etiological agent of cervical cancer. The high-risk HPV16 is the most prevalent HPV genotype worldwide and its DNA is detectable in more than 50% of all cervical tumours. The ...
Investigation of the protein components in a bacterial small RNA-mediated defense system
Prokaryotes are constantly exposed to mobile genetic elements (MGEs), such as plasmids or bacteriophage (phage). Encounters with MGEs can be beneficial and equip the host with useful traits such as antibiotic resistance ...
Investigating the Early Immune Response to Mycobacterial Infection in Mice
Mycobacterium tuberculosis is an air-borne pathogen that causes more death each year than any other bacterial infection. The current vaccine, Bacillus Calmette-Guerin (BCG), is considered one of the most widely distributed ...
CRP is a global regulator of carbon catabolism and energy metabolism in Mycobacterium smegmatis
Members of the genus Mycobacterium respire using two terminal respiratory oxidases: a cytochrome bd-type menaquinol oxidase (encoded by cydABDC) or an aa3-type menaquinol-cytochrome c oxidase. During the transition to ...
Characterisation of siderophore producing marine bacteria
Marine bacteria are diverse and highly abundant in the oceans. Under iron-depleted conditions, marine bacteria produce an iron chelator called a siderophore to scavenge for iron. Very little is known about siderophore ...
Molecular and structural analysis of natural variants of Parapoxvirus chemokine binding proteins reveals a diverse range of chemokine class specificity
The Poxvirus family is a group of large DNA viruses whose host range encompasses both vertebrate and invertebrate hosts. Their large genomes allow them to encode genes for replication and assembly as well as numerous ...
The physiological role of AtpI and AtpE of F-type ATP synthases in bacterial energetics
Bacterial F-type ATP synthases are large molecular weight protein complexes composed of a membrane-embedded portion Fo, and a large cytoplasmic portion F1. The complete enzyme complex consists of eight subunits (α3, β3, ...