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Physiological roles of the three [NiFe]-hydrogenases in Mycobacterium smegmatis
Mycobacterium is a genus of Actinobacteria that is represented by successful environmental saprophytes and notorious obligate pathogens. Despite primarily deriving their energy from aerobic respiration of organic carbon ...
Characterization of ORFV119
A large number of viruses are known to produce proteins that interact with pRB. For the most part these are small DNA viruses, such as Adenovirus and Human papilloma virus, which require that the cell be in a replicative ...
Characterising a large population of langerin+, MHC-II+ cells in mouse skin wounds
Developing a thorough understanding of wound healing is crucial given the importance of the skin and the many challenges medical professionals face when it is damaged. The immune system is very involved in the healing ...
Investigating the Site of Innate Lymphoid Cell Division Following BCG Vaccination
Tuberculosis (TB) is the most deadly infectious disease worldwide, killing 1.4 million people each year. Efforts to control the spread of this disease through antibiotic treatments and a century-old preventative vaccine, ...
Immunisation with chitosan hydrogel generates CD8+ memory T cells protective against tumour challenge
Vaccination is used in the prevention of disease around the world. Through activation of T and B cells, and subsequent generation of memory cells, long lasting protection against disease is given. The majority of vaccines ...
Efficacy of Prototype Vaccines for Prevention of Tuberculosis
Tuberculosis (TB) is a pulmonary disease caused by Mycobacterium tuberculosis, which killed 1.5 million people in 2014. The current TB vaccine, live attenuated Mycobacterium bovis bacille Calmette Guérin (BCG), effectively ...
Engineering electrospun nanofibres with orf virus proteins for improved wound healing
Wounded skin, in patients with underlying disease, can become inflamed and unable to heal (1). The economic burden of chronic wounds is significant and expected to rise substantially in the future. Current treatments are ...
Modulating the immune response to colorectal cancer in mice using a chitosan gel vaccine
Vaccines modulate the host’s anti-tumour immune response and represent an area of emerging immunotherapy research for the treatment of cancer, including colorectal cancer (CRC). Murine subcutaneous (SC) injections of tumour ...
The human kinases mTOR, PKC-α, and their substrate Filamin A promote infection of human cells by Listeria monocytogenes
The bacterium Listeria monocytogenes is a food borne intracellular pathogen capable of causing gastroenteritis, abortions, or meningitis with a high mortality rate. Listeria is a facultative intracellular pathogen that ...
Defining the role of respiratory oxidase function in mycobacteria
Members of the Mycobacterium genus are well known for their energetic flexibility, a trait which they exploit to grow and survive under a wide range of oxygen tensions, including hypoxia. Contributing to this flexibility ...