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The Interface of Metastatic Tumours and the Immune System
Primary tumours are rarely lethal; instead most cancer deaths are due to the spreading of the tumour to other sites in the body (metastasis). One major pathway of metastatic disease is the migration of tumour cells from ...
Growth Inhibition of Mycobacteria by Innate Lymphoid Cells
Tuberculosis (TB) is a lung disease caused by Mycobacterium tuberculosis (Mtb), which was responsible for 1.6 million deaths in 2017. The only vaccine against TB; bacille Calmette Guérin (BCG), protects against miliary and ...
Community assembly drivers shift from bottom-up to top-down in a maturing in situ marine biofilm model
Technological advances have promoted the identification of microbial community compositions, but the underlying assembly mechanisms and rules governing successions remain poorly studied and understood. Previous studies ...
ORFV virus manipulation of type I interferon expression
Orf virus (ORFV) is the type species of the Parapoxvirus genus that belongs to the Poxviridae family. ORFV is an epitheliotropic virus inducing cutaneous pustular skin lesions in sheep and goats and is transmissible to ...
Thermal Selection of Seneca Valley Virus Gives Rise to a Novel Thermostable Mutant
This project aimed to improve the stability of the novel oncolytic virus, Seneca Valley virus (SVV). This was with the overarching goal of determining the residues and mutations thereof within the viral capsid that are ...
Investigating the invasion biology of Plasmodium vivax using its sister species, Plasmodium cynomolgi
The erythrocytic stages of the relapsing human malaria parasite, Plasmodium vivax (P. vivax), preferentially invades immature CD71+ reticulocytes. This strict tropism for nascent reticulocytes is the primary reason for the ...