Pharmacology and Toxicology
Recent Deposits
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Development of SMA-RL71 as a nanomedicine for the treatment of triple negative breast cancer
Patients diagnosed with triple negative breast cancer (TNBC) have a poor prognosis, due in part to the lack of targeted treatment options. In the search for novel drugs, a second-generation curcumin derivative, ... -
Controlled Delivery of Nitric Oxide Using Stable and Stimuli-Responsive S-nitrosothiols
Nitric oxide (NO) is a short-lived, endogenously produced gas which plays multiple roles in mammalian physiology. A broad range of NO donors has emerged as potential therapeutics in different pathological processes including ... -
Temporal Effects of Acoustic Trauma-Induced Tinnitus on the Extracellular Levels of Amino Acids in the Inferior Colliculus of Rats.
Tinnitus is often defined as the perception of sound in the absence of a physical or an external acoustic source. While the exact underlying causes of tinnitus remain poorly understood, there is growing evidence to suggest ... -
Neuronal activity in the striatum in response to vestibular stimulation
There has been speculation into connections between the basal ganglia and the vestibular system for the last century. However, the results of studies investigating these connections have been inconsistent and controversial. ... -
Health risk assessment and health risk management with special reference to sodium monofluoroacetate (1080) for Possum control in New Zealand
The principal use of sodium monofluoroacetate (1080) in New Zealand is to control brushtail possums (Trichosurus vulpecula). Aerial application of baits containing 1080 is the most common method used for large-scale control ... -
Adrenergic stimulation of HK-2 proximal tubular cells in hyperglycaemic conditions
One of the most commonly associated complications of Diabetes Mellitus is nephropathy, with one in five diabetics sustaining renal injury over their lives. Renal denervation has been shown to decrease systemic blood pressure ... -
The Cytotoxicity and Action of Curcumin Derivatives against Fn14+ Triple Negative Breast Cancer through repression of NF-κB p65
Triple negative breast cancer (TNBC) is an aggressive subtype of the disease which lacks options for targeted systemic therapies due to a lack of actionable clinical targets. Molecular analysis has revealed that Fn14, a ... -
The Cytotoxic Mechanism of RL112 in Ovarian Cancer Cells
Background: Ovarian cancer is the most lethal gynecological malignancy among women, and there is limited treatment. The search for effective therapies for ovarian cancer has led to the emergence of natural compounds such ... -
Design, Synthesis and Structure-Activity Relationships of Some Novel Thiol Peroxidase Mimics
This study was designed to examine the structure activity relationships (SARs) between thiol peroxidase (TPx) activity, cytotoxicity and anti-oxidant versus pro-oxidant properties for homologous series of phenyl alkyl ... -
How Bone Marrow Mesenchymal Stem Cells Influence the Metastasis of Breast Cancer
Mesenchymal stem cells (MSCs) are multipotent non-haematopoietic cells primarily originating from within the bone marrow. Physiologically they aid in the process of wound healing. However, MSCs are also recruited by cancer ... -
Anticancer Potential of Novel Curcumin Analogues towards Hormone-Refractory Prostate Cancer
Prostate cancer, a hormonally driven and dependent malignancy, is a leading cause of cancer-related deaths in men. Hormonal therapy including surgical castration and medical/chemical castration to cause regression of ... -
Low dose inhaled carbon monoxide and cardiac ischaemia reperfusion injury
INTRODUCTION Low dose carbon monoxide (CO), a byproduct of heme oxygenase, has been shown to cause vasodilatation, modify platelet adherence, reduce inflammation and inhibit apoptosis. Cardiac ischaemia-reperfusion (IR) ... -
Targeting the Anaplastic Lymphoma Kinase (ALK) and the Insulin-like Growth Factor Receptor 1 (IGF1R) in crizotinib resistant lung cancer cells
Non-small lung cancer (NSCLC) accounts for approximately 85% of all lung cancer-related deaths worldwide. Historically, platinum-based chemotherapy regimens have been the first-line treatment for advanced NSCLC, however ... -
The effect of vestibular lesions on the hippocampal cholinergic system
Bilateral vestibular loss (BVL) produces profound behavioural changes, some of which do not appear to be directly associated with the acute loss of vestibular information, such as hyperlocomotion and spatial memory ... -
The use of combination tyrosine kinase inhibitors for the treatment of glioblastoma multiforme
Glioblastoma is the most common primary brain tumor which has a median survival of only 14.6 months. The central nervous system localization, heterogeneity of the cells and resistance to treatment constitute a significant ... -
Comparison of Spironolactone versus Amlodipine in Hypertensive Cardiorenal Pathology
Hypertension is endemic worldwide, afflicting up to 40% of the global population over the age of 25. Haemodynamic stretch stress from raised blood pressure is a driver for organ damage in the heart and kidney, contributing ... -
Identification of differentially expressed genes in response to treatment with RL71 and SMA-RL71 in triple negative breast cancer cell lines
Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype characterised by a poor outcome when compared to other breast cancers. The lack of safe and targeted therapy for TNBC promotes the need for the ... -
Styrene maleic acid micelles as a nanocarrier system for oral anticancer drug delivery
ABSTRACT The oral route is the preferred mode of drug administration due to its non-invasive nature, economical benefits, and the potential to improve patients’ quality of life. Oral administration of anticancer agents ... -
A Novel Mechanism for Nicotinic Acetylcholine Receptor Antagonist-Induced Cancer Cell Cytotoxicity
Nicotinic acetylcholine receptors (nAChRs) are common ligand-activated neurotransmitter receptors located throughout the body. The up-regulation of nAChRs subunits has been observed in a number of cancer types; while current ... -
Using Raloxifene and the Curcumin Derivative, RL91, for the Treatment of Castrate Resistant Prostate Cancer
Prostate cancer is the second most diagnosed cancer worldwide and accounts for 15% of all cancer in men. Localised prostate cancer, contained within the capsule of the prostate gland, is effectively treated with surgery, ...