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Pharmacology and Toxicology

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Targeting the Anaplastic Lymphoma Kinase (ALK) and the Insulin-like Growth Factor Receptor 1 (IGF1R) in crizotinib resistant lung cancer cells

Wilson, Christabel (Thesis, Master of Science, 2017)

Non-small lung cancer (NSCLC) accounts for approximately 85% of all lung cancer-related deaths worldwide. Historically, platinum-based chemotherapy regimens have been the first-line treatment for advanced NSCLC, however ...
The effect of vestibular lesions on the hippocampal cholinergic system

Aitken, Phillip (Thesis, Doctor of Philosophy, 2017)

Bilateral vestibular loss (BVL) produces profound behavioural changes, some of which do not appear to be directly associated with the acute loss of vestibular information, such as hyperlocomotion and spatial memory ...
The use of combination tyrosine kinase inhibitors for the treatment of glioblastoma multiforme

Nehoff, Hayley (Thesis, Doctor of Philosophy, 2016)

Glioblastoma is the most common primary brain tumor which has a median survival of only 14.6 months. The central nervous system localization, heterogeneity of the cells and resistance to treatment constitute a significant ...
Comparison of Spironolactone versus Amlodipine in Hypertensive Cardiorenal Pathology

Strickland, James Todd Langdale (Thesis, Bachelor of Medical Science with Honours, 2016)

Hypertension is endemic worldwide, afflicting up to 40% of the global population over the age of 25. Haemodynamic stretch stress from raised blood pressure is a driver for organ damage in the heart and kidney, contributing ...
Identification of differentially expressed genes in response to treatment with RL71 and SMA-RL71 in triple negative breast cancer cell lines

Wang, Yue (Thesis, Master of Science, 2016)

Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype characterised by a poor outcome when compared to other breast cancers. The lack of safe and targeted therapy for TNBC promotes the need for the ...
Styrene maleic acid micelles as a nanocarrier system for oral anticancer drug delivery

Parayath, Neha Nitin (Thesis, Doctor of Philosophy, 2016)

ABSTRACT The oral route is the preferred mode of drug administration due to its non-invasive nature, economical benefits, and the potential to improve patients’ quality of life. Oral administration of anticancer agents ...
A Novel Mechanism for Nicotinic Acetylcholine Receptor Antagonist-Induced Cancer Cell Cytotoxicity

Clarke, Mitchell Raymond (Thesis, Master of Science, 2016)

Nicotinic acetylcholine receptors (nAChRs) are common ligand-activated neurotransmitter receptors located throughout the body. The up-regulation of nAChRs subunits has been observed in a number of cancer types; while current ...
Using Raloxifene and the Curcumin Derivative, RL91, for the Treatment of Castrate Resistant Prostate Cancer

Palmer, Hannah (Thesis, Master of Science, 2015)

Prostate cancer is the second most diagnosed cancer worldwide and accounts for 15% of all cancer in men. Localised prostate cancer, contained within the capsule of the prostate gland, is effectively treated with surgery, ...
Elucidation of the Anticancer Mechanism of Action of a Novel Di-Palladium Helicate

McNeill, Samantha Marie (Thesis, Master of Science, 2015)

Metal-based therapeutics are utilised in up to 50% of anticancer treatments. However, the therapeutic use of these agents is limited by the lack of target specificity and the development of patient resistance to therapy. ...
The Effect of Photoactivation on the Mechanism of Action of tDodSNO

Nield-Patterson, Andrea (Thesis, Master of Science, 2015)

Since the discovery and identification of nitric oxide (NO) in vivo more than 30 years ago, a wealth of knowledge has been collected regarding its biological action. More recently, NO has been shown to be a valuable ...
In Vitro Analysis for the use of Honey Bee Products in the Treatment of Metastatic Prostate Cancer

Abel, Sean (Thesis, Master of Science, 2015)

The prognosis for men diagnosed with advanced metastatic prostate cancer is poor. A low five-year survival rate of 28% highlights the ongoing need for improved treatment options, with attention to a reduction in prostate ...
Heterocyclic Cyclohexanone Curcumin Analogues Inhibit Growth of Ovarian Cancer Cells, in-vitro

Gwavava, Patrick (Thesis, Master of Science, 2015)

Background: Ovarian cancer is the most lethal gynaecological cancer in women. Nearly a quarter of a million women are newly diagnosed globally, with up to 140,200 lives lost annually. The high mortality is attributed to ...
SMA-raloxifene for the management of castrate-resistant prostate cancer

Pritchard, Tara Cheree (Thesis, Master of Science, 2015)

Castrate-resistant prostate cancer (CRPC) has a poor prognosis, and these tumours are refractory to conventional androgen deprivation therapy. In addition to androgen, oestrogen alone or combined with androgen induces ...
Therapeutic Approaches in the Attenuation of Seizure-Induced Cardiomyopathy

Andreianova, Anastasia Alexeevna (Thesis, Master of Science, 2015)

Single subcutaneous administration of Kainic acid (KA) in the rat produces significant levels of seizure activity, including head tremors, salivation and tonic-clonic convulsions. Using electrophysiological quantitative ...
Seizure-induced cardiomyopathy: Benefit of Atenolol

Read, Morgayn (Thesis, Doctor of Philosophy, 2015)

Epilepsy affects 1-2% of the population in New Zealand and is associated with an increased mortality rate of two to three times that of the general population. This thesis examines the effect of seizures on cardiac function, ...
Pharmacological Intervention with Atenolol and Diazepam in Seizure-Induced Cardiomyopathy

Millen, Rebecca Nicole (Thesis, Master of Science, 2015)

Seizures have become frequently associated with an increased risk of cardiomyopathy, with tachycardia and pathological structural changes commonly reported in both clinical and animal studies. This thesis examined the ...
Comparison of Cardioprotective Therapy with Atenolol and Diltiazem in Seizure-Induced Cardiomyopathy

McCann, Dominic Michael (Thesis, Master of Science, 2015)

Seizure-induced autonomic dysregulation is frequently linked with the development of cardiac abnormalities. The current study examined the therapeutic effects of pre- and post-treatment with atenolol or diltiazem in a model ...
Investigating the Mechanisms of Pharmacological Preconditioning In Vitro and In Vivo

Goulton, Chelsea Sarah (Thesis, Doctor of Philosophy, 2015)

Preconditioning involves the induction of endogenous protective mechanisms to prevent damage due to subsequent insult. The acute window of protection could provide a neuroprotective strategy for patients with a known risk ...
Evaluation of SMA-RL71, a curcumin analogue nanomicelle as a drug in xenograft models of triple negative breast cancer

Sundararajan, Vignesh (Thesis, Master of Science, 2014)

Triple negative breast cancer (TNBC) is a subtype of ER (-) cancer that currently has no treatment options. A novel drug formulation of the most potent curcumin analogue (RL71), compared to the analogues synthesised by ...
Mechanism of action of pinnatoxins E, F and G

Hellyer, Shane Dennis (Thesis, Doctor of Philosophy, 2014)

Pinnatoxins E, F and G are the three most recently discovered isomers of the pinnatoxin family. Pinnatoxins belong to the cyclic imine group of toxins that causes a fast-acting, “all or nothing” toxic response in rodent ...