Pharmacology and Toxicology
Recent Deposits
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oCOm-21 as a Cardioprotective Inotrope Through S-Nitrosylation
Patients with severe ischaemic heart disease (IHD) often undergo cardiac surgery to alleviate symptoms and improve survival outcomes. However, such interventions can inevitably induce episodes of ischaemia reperfusion (IR). ... -
Cardioprotective Potential of the Novel Organic Carbon Monoxide Releasing Molecule (oCOm-21) in Normotrophic and Hypertrophic Hearts
The imposition of ischaemia reperfusion episodes in frequently used cardiac surgery interventions involving cardiopulmonary bypass can induce perioperative complications, such as myocardial injury, arrhythmias, and end ... -
Investigation into the Anticancer Mechanism of Action of Novel 4-Substituted Phenylthiazoles and Antihelminthic Benzimidazoles
Recently, two novel 4-substituted phenylthiazoles, D1 and D2, have been synthesised based upon the marine bacterial secondary metabolite anithiactin A/thiasporine C, and shown to be cytotoxic towards cancer cells below 100 ... -
The Impact of Renal Denervation on Structural Changes of Diabetic Nephropathy
Chronic bilateral renal denervation has been shown in clinical and experimental studies to reduce systemic blood pressure in resistant hypertension, along with protective effects on the kidney. However, the role of bilateral ... -
Effects of Acoustic Trauma on the Induction of Long-term Potentiation in the Inferior Colliculus of Rats
Tinnitus is an auditory disorder that is commonly classified as a ringing in the ears without an external sound source. Tinnitus is mainly correlated with increased age, however, noise exposure to loud sounds is also ... -
Development of a viral chemokine binding protein as a diagnostic tool for chemokine detection.
Chemokines serve an integral role in the inflammatory response, specifically through the development of a chemotactic gradient which directs the trafficking of inflammatory leukocytes to the site of tissue damage or ... -
Anti-Cancer Mechanism of Phenyl Selenides in Breast Cancer
Breast cancer can be divided into a number of subtypes based upon receptor expression. Of these triple-negative breast cancer (TNBC) is the most aggressive subtype and is highly challenging to treat, as it has no targeted ... -
Development of SMA-RL71 as a nanomedicine for the treatment of triple negative breast cancer
Patients diagnosed with triple negative breast cancer (TNBC) have a poor prognosis, due in part to the lack of targeted treatment options. In the search for novel drugs, a second-generation curcumin derivative, ... -
Controlled Delivery of Nitric Oxide Using Stable and Stimuli-Responsive S-nitrosothiols
Nitric oxide (NO) is a short-lived, endogenously produced gas which plays multiple roles in mammalian physiology. A broad range of NO donors has emerged as potential therapeutics in different pathological processes including ... -
Temporal Effects of Acoustic Trauma-Induced Tinnitus on the Extracellular Levels of Amino Acids in the Inferior Colliculus of Rats.
Tinnitus is often defined as the perception of sound in the absence of a physical or an external acoustic source. While the exact underlying causes of tinnitus remain poorly understood, there is growing evidence to suggest ... -
Neuronal activity in the striatum in response to vestibular stimulation
There has been speculation into connections between the basal ganglia and the vestibular system for the last century. However, the results of studies investigating these connections have been inconsistent and controversial. ... -
Health risk assessment and health risk management with special reference to sodium monofluoroacetate (1080) for Possum control in New Zealand
The principal use of sodium monofluoroacetate (1080) in New Zealand is to control brushtail possums (Trichosurus vulpecula). Aerial application of baits containing 1080 is the most common method used for large-scale control ... -
Adrenergic stimulation of HK-2 proximal tubular cells in hyperglycaemic conditions
One of the most commonly associated complications of Diabetes Mellitus is nephropathy, with one in five diabetics sustaining renal injury over their lives. Renal denervation has been shown to decrease systemic blood pressure ... -
The Cytotoxicity and Action of Curcumin Derivatives against Fn14+ Triple Negative Breast Cancer through repression of NF-κB p65
Triple negative breast cancer (TNBC) is an aggressive subtype of the disease which lacks options for targeted systemic therapies due to a lack of actionable clinical targets. Molecular analysis has revealed that Fn14, a ... -
The Cytotoxic Mechanism of RL112 in Ovarian Cancer Cells
Background: Ovarian cancer is the most lethal gynecological malignancy among women, and there is limited treatment. The search for effective therapies for ovarian cancer has led to the emergence of natural compounds such ... -
Design, Synthesis and Structure-Activity Relationships of Some Novel Thiol Peroxidase Mimics
This study was designed to examine the structure activity relationships (SARs) between thiol peroxidase (TPx) activity, cytotoxicity and anti-oxidant versus pro-oxidant properties for homologous series of phenyl alkyl ... -
How Bone Marrow Mesenchymal Stem Cells Influence the Metastasis of Breast Cancer
Mesenchymal stem cells (MSCs) are multipotent non-haematopoietic cells primarily originating from within the bone marrow. Physiologically they aid in the process of wound healing. However, MSCs are also recruited by cancer ... -
Anticancer Potential of Novel Curcumin Analogues towards Hormone-Refractory Prostate Cancer
Prostate cancer, a hormonally driven and dependent malignancy, is a leading cause of cancer-related deaths in men. Hormonal therapy including surgical castration and medical/chemical castration to cause regression of ... -
Low dose inhaled carbon monoxide and cardiac ischaemia reperfusion injury
INTRODUCTION Low dose carbon monoxide (CO), a byproduct of heme oxygenase, has been shown to cause vasodilatation, modify platelet adherence, reduce inflammation and inhibit apoptosis. Cardiac ischaemia-reperfusion (IR) ... -
Targeting the Anaplastic Lymphoma Kinase (ALK) and the Insulin-like Growth Factor Receptor 1 (IGF1R) in crizotinib resistant lung cancer cells
Non-small lung cancer (NSCLC) accounts for approximately 85% of all lung cancer-related deaths worldwide. Historically, platinum-based chemotherapy regimens have been the first-line treatment for advanced NSCLC, however ...