Pharmacology and Toxicology
Recent Deposits
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An old drug with new tricks; examining the anti-cancer potential of metformin in mouse and cell models of EML4- ALK+ non-small cell lung cancer
Lung cancer is an aggressive disease producing the highest cancer worldwide. Non-small cell lung cancer (NSCLC) accounts for the majority of all lung cancer cases. The discovery of oncogenic receptor tyrosine kinases (RTKs) ... -
Distinct Patterns of Internalization of Different Calcitonin GeneRelated Peptide Receptors
Calcitonin gene-related peptide (CGRP) is a neuropeptide that is involved in the transmission of pain. Drugs targeting CGRP or a CGRP receptor are efficacious in the treatment of migraine. The canonical CGRP receptor is a ... -
Formulation and evaluation of a stable penethamate hydriodide intramuscular injection for treatment of bovine mastitis
Purpose: The aim of this thesis was to investigate the stability of penethamate (PNT), an ester prodrug of benzylpenicillin (BP), used intramuscularly (i.m.) in the treatment of bovine mastitis. The specific objectives ... -
Evaluating the Antimicrobial and Antibiofilm Activity of a Lipid Extract from the Giant Kelp Macrocystis pyrifera
Skin and soft tissue infections (SSTIs) affect millions of individuals worldwide, every year. SSTIs vary in complexity and severity, ranging from superficial skin infections such as impetigo to more severe, polymicrobial, ... -
Impact of carbon monoxide releasing oCOm-21 on the NLRP3 inflammasome
During cardiac bypass procedure, the heart is subjected to repeat cycles of ischaemia reperfusion injury (IRI). This is highly detrimental to clinical outcomes in patients, presenting as myocardial dysfunction and contributing ... -
The effect of combination drug inhibition of ALK and Src on cell growth in ALK-positive non-small cell lung cancer
Lung cancer is the leading cause of cancer mortality worldwide, accounting for approximately 1.6 million deaths per annum. The most common form of lung cancer is non-small cell lung cancer, and within this, ALK mutations ... -
Combination of ALK and MEK inhibitors for the treatment of ALK-positive non-small cell lung cancer
Anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) most commonly arises through Echinoderm microtubule-associated protein like 4 (EML4)-ALK chromosomal fusion and is associated with younger aged ... -
Novel drug development for KRAS-mutated non-small cell lung cancer
Lung cancer is the leading cause of cancer-related death among both men and women and non-small cell lung cancer (NSCLC) accounts for 85 to 88% of all lung cancer cases. In NSCLC, kirsten rat sarcoma (KRAS) viral oncogene ... -
Oral delivery of peptides to salmon
Purpose. Oral delivery of peptide and protein drugs to fish has potential advantages to the aquaculture industry. However, the bioavailability of proteins and peptides from the intestinal tract is very low. This can be ... -
Investigation into the mechanism of action and chemical enhancement of transdermal iontophoreses of LHRH
Recent developments in drug design and advances in mapping of the human genome have quickened the pace of development of peptide and protein drugs. Unfortunately, this class of compound often has specialised delivery ... -
Biosorption of heavy metals from drinking water using fruit and vegetable peels
Heavy metals in drinking water are a serious global concern and efforts are underway to develop sustainable decontamination techniques. The present project was developed with an aim to prepare biosorbents for treating ... -
The Efficacy and Mechanism of Action of HDAC Inhibitors in Triple Negative Breast Cancer
Histone deacetylase inhibitors (HDACis) are a class of chemically heterogeneous anticancer agents which consist of a hydrophobic capping group, linker region, and Zn 2+ chelating pharmacophore. Manipulation of these three ... -
Mesenchymal stem cells homing to tumour sites: Cancer biology and therapy
Mesenchymal stem cells (MSCs) are bone marrow derived, non-hematopoietic stem cells, which home to sites of injury and inflammation. They have also been identified at tumour sites where they can have pro- or anti-tumourigenic ... -
oCOm-21 as a Cardioprotective Inotrope Through S-Nitrosylation
Patients with severe ischaemic heart disease (IHD) often undergo cardiac surgery to alleviate symptoms and improve survival outcomes. However, such interventions can inevitably induce episodes of ischaemia reperfusion (IR). ... -
Cardioprotective Potential of the Novel Organic Carbon Monoxide Releasing Molecule (oCOm-21) in Normotrophic and Hypertrophic Hearts
The imposition of ischaemia reperfusion episodes in frequently used cardiac surgery interventions involving cardiopulmonary bypass can induce perioperative complications, such as myocardial injury, arrhythmias, and end ... -
Investigation into the Anticancer Mechanism of Action of Novel 4-Substituted Phenylthiazoles and Antihelminthic Benzimidazoles
Recently, two novel 4-substituted phenylthiazoles, D1 and D2, have been synthesised based upon the marine bacterial secondary metabolite anithiactin A/thiasporine C, and shown to be cytotoxic towards cancer cells below 100 ... -
The Impact of Renal Denervation on Structural Changes of Diabetic Nephropathy
Chronic bilateral renal denervation has been shown in clinical and experimental studies to reduce systemic blood pressure in resistant hypertension, along with protective effects on the kidney. However, the role of bilateral ... -
Effects of Acoustic Trauma on the Induction of Long-term Potentiation in the Inferior Colliculus of Rats
Tinnitus is an auditory disorder that is commonly classified as a ringing in the ears without an external sound source. Tinnitus is mainly correlated with increased age, however, noise exposure to loud sounds is also ... -
Development of a viral chemokine binding protein as a diagnostic tool for chemokine detection.
Chemokines serve an integral role in the inflammatory response, specifically through the development of a chemotactic gradient which directs the trafficking of inflammatory leukocytes to the site of tissue damage or ... -
Anti-Cancer Mechanism of Phenyl Selenides in Breast Cancer
Breast cancer can be divided into a number of subtypes based upon receptor expression. Of these triple-negative breast cancer (TNBC) is the most aggressive subtype and is highly challenging to treat, as it has no targeted ...