Browsing Pharmacology and Toxicology by Title
Now showing items 21-40 of 70
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The Effects of Baclofen on Chronic Tinnitus Induced By Acoustic Trauma
Tinnitus is characterised by a phantom ringing in the ear. Approximately twelve million Americans experience tinnitus in a form severe enough to require medical attention. Despite this prevalence there is no effective ... -
Elucidation of the Anticancer Mechanism of Action of a Novel Di-Palladium Helicate
Metal-based therapeutics are utilised in up to 50% of anticancer treatments. However, the therapeutic use of these agents is limited by the lack of target specificity and the development of patient resistance to therapy. ... -
Evaluation of SMA-RL71, a curcumin analogue nanomicelle as a drug in xenograft models of triple negative breast cancer
Triple negative breast cancer (TNBC) is a subtype of ER (-) cancer that currently has no treatment options. A novel drug formulation of the most potent curcumin analogue (RL71), compared to the analogues synthesised by ... -
Evidence of Renal Dysfunction, and Sclerotic Damage Secondary to Chronic Heart Failure; an Inbred Rat Model of Type 2 Cardiorenal Syndrome
Cardiovascular disease is the leading killer within the western world. Direct pathological interactions have been shown to exist between cardiovascular disease, and the development of renal disease, and vice versa. This ... -
Examination of the Hypothalamic Paraventricular Nucleus in a Rat Model of Chronic Ischaemic Myocardial Injury
Ischaemic heart disease, including heart failure (HF) is a leading cause of death worldwide. Despite pharmacological intervention, HF remains a progressive disease with a high mortality rate. The role of the central nervous ... -
Glutamate Receptors in the Medial Temporal Lobe Following Bilateral Vestibular Deafferentation
Dysfunction of the vestibular system can be caused by a number of conditions including Meniere‘s disease and aminoglycoside antibiotic induced damage. Bilateral vestibular damage results in symptoms such as vertigo, ... -
Health risk assessment and health risk management with special reference to sodium monofluoroacetate (1080) for Possum control in New Zealand
The principal use of sodium monofluoroacetate (1080) in New Zealand is to control brushtail possums (Trichosurus vulpecula). Aerial application of baits containing 1080 is the most common method used for large-scale control ... -
Heterocyclic Cyclohexanone Curcumin Analogues Inhibit Growth of Ovarian Cancer Cells, in-vitro
Background: Ovarian cancer is the most lethal gynaecological cancer in women. Nearly a quarter of a million women are newly diagnosed globally, with up to 140,200 lives lost annually. The high mortality is attributed to ... -
How Bone Marrow Mesenchymal Stem Cells Influence the Metastasis of Breast Cancer
Mesenchymal stem cells (MSCs) are multipotent non-haematopoietic cells primarily originating from within the bone marrow. Physiologically they aid in the process of wound healing. However, MSCs are also recruited by cancer ... -
Identification of differentially expressed genes in response to treatment with RL71 and SMA-RL71 in triple negative breast cancer cell lines
Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype characterised by a poor outcome when compared to other breast cancers. The lack of safe and targeted therapy for TNBC promotes the need for the ... -
In Vitro Analysis for the use of Honey Bee Products in the Treatment of Metastatic Prostate Cancer
The prognosis for men diagnosed with advanced metastatic prostate cancer is poor. A low five-year survival rate of 28% highlights the ongoing need for improved treatment options, with attention to a reduction in prostate ... -
Intranasal VEGF-A and VEGF-E in a modified Levine model of stroke
VEGF (Vascular endothelial growth factor)-A has been shown to successfully enter the brain via the intranasal pathway and improve symptoms following focal ischemia in rats. However VEGF-A promotes inflammation and vascular ... -
Investigating the Mechanisms of Pharmacological Preconditioning In Vitro and In Vivo
Preconditioning involves the induction of endogenous protective mechanisms to prevent damage due to subsequent insult. The acute window of protection could provide a neuroprotective strategy for patients with a known risk ... -
Investigation into the Anticancer Mechanism of Action of Novel 4-Substituted Phenylthiazoles and Antihelminthic Benzimidazoles
Recently, two novel 4-substituted phenylthiazoles, D1 and D2, have been synthesised based upon the marine bacterial secondary metabolite anithiactin A/thiasporine C, and shown to be cytotoxic towards cancer cells below 100 ... -
Low dose inhaled carbon monoxide and cardiac ischaemia reperfusion injury
INTRODUCTION Low dose carbon monoxide (CO), a byproduct of heme oxygenase, has been shown to cause vasodilatation, modify platelet adherence, reduce inflammation and inhibit apoptosis. Cardiac ischaemia-reperfusion (IR) ... -
Mechanism of action of pinnatoxins E, F and G
Pinnatoxins E, F and G are the three most recently discovered isomers of the pinnatoxin family. Pinnatoxins belong to the cyclic imine group of toxins that causes a fast-acting, “all or nothing” toxic response in rodent ... -
Neuroinflammation and Cannabinoid CB2 Receptor Expression in the Human Huntington's Disease Brain and R6/1 Transgenic Mouse Model
Neuroinflammation is recognised as a common feature of the pathological disease process in a number of chronic neurodegenerative conditions including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis and ... -
Neuronal activity in the striatum in response to vestibular stimulation
There has been speculation into connections between the basal ganglia and the vestibular system for the last century. However, the results of studies investigating these connections have been inconsistent and controversial. ... -
Novel drug therapies for ER- basal-like breast cancer; preclinical evaluation in a xenograft model.
Basal-like breast cancers are a subgroup of breast lesions that are triple-negative for the estrogen receptor (ER), progesterone receptor and human epidermal growth factor receptor 2. There is currently no effective treatment ... -
Novel Organic Carbon Monoxide Releasing Molecules as a Potential Treatment for Triple Negative Breast Cancer
Carbon monoxide (CO) plays a role in many physiological and pathophysiological processes as a second messenger. Emerging evidence reveals the potential CO has as a therapeutic agent as it has been implicated in the modulation ...