Browsing Pharmacology and Toxicology by Title
Now showing items 7-26 of 70
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Carbon Monoxide and Hypothermic Pulsatile Perfusion in Renal Transplantation
Chronic kidney disease is a highly prevalent condition and renal transplantation is the definitive treatment for those with end stage renal failure. This life saving treatment is unfortunately hindered by a shortage of ... -
Cardiac Injury during Kainic Acid Induced Seizures: Effects of Gender on ECG
Epilepsy is associated with an increased mortality rate. In 7 to 17% of epileptics, the cause of death is unknown and this has been termed sudden unexplained death in epilepsy (SUDEP). Seizure-induced cardiac changes have ... -
Cellular and electrophysiological investigations of nitric oxide protection against a model of oxidative stress
Since the discovery of nitric oxide (NO) during the 1980’s, there has been great interest in the molecule’s mechanism of action. The main function of NO is thought to be as a second messenger in cell signalling pathways; ... -
Changes in the Endocannabinoid system in the Brain Following Bilateral Vestibular Damage
Numerous studies have shown that bilateral vestibular deafferentation (BVD) results in spatial memory deficits and hippocampal dysfunction in rats and humans. These deficits appear to be long-lasting, suggesting long-term ... -
Characterisation of Novel Nitric Oxide and Carbon Monoxide Donors
Nitrogen monoxide (NO) and carbon monoxide (CO) are small messenger molecules which play multiple roles in mammalian physiology. Currently, available NO and CO donor drugs are limited in therapeutic potential due to a lack ... -
Chronic Bilateral Renal Denervation in Experimental Diabetic Nephropathy
Chronic bilateral renal denervation (BRD) has been shown to reduce systemic blood pressure and improve insulin sensitivity and renal function in both human and experimental animal models. However, the effect of chronic BRD ... -
Comparison of Cardioprotective Therapy with Atenolol and Diltiazem in Seizure-Induced Cardiomyopathy
Seizure-induced autonomic dysregulation is frequently linked with the development of cardiac abnormalities. The current study examined the therapeutic effects of pre- and post-treatment with atenolol or diltiazem in a model ... -
Comparison of Spironolactone versus Amlodipine in Hypertensive Cardiorenal Pathology
Hypertension is endemic worldwide, afflicting up to 40% of the global population over the age of 25. Haemodynamic stretch stress from raised blood pressure is a driver for organ damage in the heart and kidney, contributing ... -
Controlled Delivery of Nitric Oxide Using Stable and Stimuli-Responsive S-nitrosothiols
Nitric oxide (NO) is a short-lived, endogenously produced gas which plays multiple roles in mammalian physiology. A broad range of NO donors has emerged as potential therapeutics in different pathological processes including ... -
Crosstalk Between Iron Homeostasis And Nitric Oxide Signalling: Impact On Cancer Cell Viability
The element iron (Fe) is essential for mammals since many enzymes require Fe as a cofactor for metabolic processes. Fe regulation is extremely important to maintain Fe homeostasis as Fe overload and Fe deprivation are ... -
Design, Synthesis and Structure-Activity Relationships of Some Novel Thiol Peroxidase Mimics
This study was designed to examine the structure activity relationships (SARs) between thiol peroxidase (TPx) activity, cytotoxicity and anti-oxidant versus pro-oxidant properties for homologous series of phenyl alkyl ... -
Development of a viral chemokine binding protein as a diagnostic tool for chemokine detection.
Chemokines serve an integral role in the inflammatory response, specifically through the development of a chemotactic gradient which directs the trafficking of inflammatory leukocytes to the site of tissue damage or ... -
Development of SMA-RL71 as a nanomedicine for the treatment of triple negative breast cancer
Patients diagnosed with triple negative breast cancer (TNBC) have a poor prognosis, due in part to the lack of targeted treatment options. In the search for novel drugs, a second-generation curcumin derivative, ... -
Effects of Acoustic Trauma on the Induction of Long-term Potentiation in the Inferior Colliculus of Rats
Tinnitus is an auditory disorder that is commonly classified as a ringing in the ears without an external sound source. Tinnitus is mainly correlated with increased age, however, noise exposure to loud sounds is also ... -
The Effects of Baclofen on Chronic Tinnitus Induced By Acoustic Trauma
Tinnitus is characterised by a phantom ringing in the ear. Approximately twelve million Americans experience tinnitus in a form severe enough to require medical attention. Despite this prevalence there is no effective ... -
Elucidation of the Anticancer Mechanism of Action of a Novel Di-Palladium Helicate
Metal-based therapeutics are utilised in up to 50% of anticancer treatments. However, the therapeutic use of these agents is limited by the lack of target specificity and the development of patient resistance to therapy. ... -
Evaluation of SMA-RL71, a curcumin analogue nanomicelle as a drug in xenograft models of triple negative breast cancer
Triple negative breast cancer (TNBC) is a subtype of ER (-) cancer that currently has no treatment options. A novel drug formulation of the most potent curcumin analogue (RL71), compared to the analogues synthesised by ... -
Evidence of Renal Dysfunction, and Sclerotic Damage Secondary to Chronic Heart Failure; an Inbred Rat Model of Type 2 Cardiorenal Syndrome
Cardiovascular disease is the leading killer within the western world. Direct pathological interactions have been shown to exist between cardiovascular disease, and the development of renal disease, and vice versa. This ... -
Examination of the Hypothalamic Paraventricular Nucleus in a Rat Model of Chronic Ischaemic Myocardial Injury
Ischaemic heart disease, including heart failure (HF) is a leading cause of death worldwide. Despite pharmacological intervention, HF remains a progressive disease with a high mortality rate. The role of the central nervous ... -
Glutamate Receptors in the Medial Temporal Lobe Following Bilateral Vestibular Deafferentation
Dysfunction of the vestibular system can be caused by a number of conditions including Meniere‘s disease and aminoglycoside antibiotic induced damage. Bilateral vestibular damage results in symptoms such as vertigo, ...