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Browsing Pharmacology and Toxicology by Title
Now showing items 43-62 of 70
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Raloxifene along with curcumin analogue RL91, a combinational approach against hormone refractory prostate cancer
Background: Approximately 80% of prostate cancer patients undergoing hormone therapy progress within 12-18 months to a hormone insensitive form of the disease known as hormone refractory prostate cancer. The median survival ... -
Raloxifene for the Treatment of Triple Negative Breast Cancer
Triple negative breast cancer (TNBC) represents a subgroup of mammary cancers associated with particularly poor prognosis as they are refractory to currently available targeted therapy used to treat other breast cancers. ... -
The role of calcium-dependent pathways in vestibular compensation
Damage to one vestibular apparatus (unilateral vestibular deafferentation, UVD) results in severe postural and ocular motor disturbances (such as spontaneous nystagmus, SN) that recover over time in a process known as ... -
Seizure-induced cardiomyopathy: Benefit of Atenolol
Epilepsy affects 1-2% of the population in New Zealand and is associated with an increased mortality rate of two to three times that of the general population. This thesis examines the effect of seizures on cardiac function, ... -
SMA-raloxifene for the management of castrate-resistant prostate cancer
Castrate-resistant prostate cancer (CRPC) has a poor prognosis, and these tumours are refractory to conventional androgen deprivation therapy. In addition to androgen, oestrogen alone or combined with androgen induces ... -
Statin-induced deficits in memory and learning: A behavioural and electrophysiological investigation
Statins play a crucial role in reducing the risk of death from cardiovascular disease in millions of people worldwide. Recently, data show people taking statins are at increased risk of a number of psychiatric adverse ... -
Study of New Curcumin Analogs for the Treatment of Erα Negative Breast Cancers
Breast cancer is the most prevalent form of cancer diagnosed in women, and there continues to be limited drug treatment options for the ~30% of patients with estrogen receptor (ERα)-negative breast cancers. In the search ... -
Styrene maleic acid micelles as a nanocarrier system for oral anticancer drug delivery
ABSTRACT The oral route is the preferred mode of drug administration due to its non-invasive nature, economical benefits, and the potential to improve patients’ quality of life. Oral administration of anticancer agents ... -
Synthetic Cannabinoids as a Novel Treatment for Triple Negative Breast Cancer
Approximately one in five breast cancer patients exhibits triple negative tumors that are characterized by the lack of estrogen receptor (ER), progesterone receptor and HER2. While ER and HER2 positive tumors are responsive ... -
Targeting the Anaplastic Lymphoma Kinase (ALK) and the Insulin-like Growth Factor Receptor 1 (IGF1R) in crizotinib resistant lung cancer cells
Non-small lung cancer (NSCLC) accounts for approximately 85% of all lung cancer-related deaths worldwide. Historically, platinum-based chemotherapy regimens have been the first-line treatment for advanced NSCLC, however ... -
Temporal Effects of Acoustic Trauma-Induced Tinnitus on the Extracellular Levels of Amino Acids in the Inferior Colliculus of Rats.
Tinnitus is often defined as the perception of sound in the absence of a physical or an external acoustic source. While the exact underlying causes of tinnitus remain poorly understood, there is growing evidence to suggest ... -
The cannabinoid CB2 receptor as a target for the treatment of neuropathic pain
Cannabinoids are cannabis-like drugs that are moderately efficacious in the treatment of some types of chronic pain, including pain of a neuropathic origin. Limiting their therapeutic application, however, are adverse ... -
The Cytotoxic Mechanism of RL112 in Ovarian Cancer Cells
Background: Ovarian cancer is the most lethal gynecological malignancy among women, and there is limited treatment. The search for effective therapies for ovarian cancer has led to the emergence of natural compounds such ... -
The Cytotoxicity and Action of Curcumin Derivatives against Fn14+ Triple Negative Breast Cancer through repression of NF-κB p65
Triple negative breast cancer (TNBC) is an aggressive subtype of the disease which lacks options for targeted systemic therapies due to a lack of actionable clinical targets. Molecular analysis has revealed that Fn14, a ... -
The effect of anxiolytic and anxiogenic drugs on spatial memory and anxiety-related behaviours in bilateral vestibular deafferented rats
Vestibular dysfunction in humans is associated with a high rate of anxiety and depressive disorders. Although this may first appear to be due to the burden of living with a balance disorder, there is reason to think that ... -
The Effect of Photoactivation on the Mechanism of Action of tDodSNO
Since the discovery and identification of nitric oxide (NO) in vivo more than 30 years ago, a wealth of knowledge has been collected regarding its biological action. More recently, NO has been shown to be a valuable ... -
The effect of vestibular lesions on the hippocampal cholinergic system
Bilateral vestibular loss (BVL) produces profound behavioural changes, some of which do not appear to be directly associated with the acute loss of vestibular information, such as hyperlocomotion and spatial memory ... -
The Effects of Direct Infusion of L-Baclofen or CGP7930 into the Dorsal Cochlear Nucleus on the Development of Noise-Induced Tinnitus in Rats
Tinnitus is a phantom auditory sensation that many experience at some point in their lives. Generally, the sensation is transient; however, an increasing number of people suffer from chronic tinnitus. Treatment options for ... -
The Effects Of Early L-Baclofen Administration On The Development Of Tinnitus Induced By Acoustic Trauma, And GABAB-R2 Expression, In Rats
Tinnitus is an illusory auditory sensation which often manifests as ‘ringing of the ears’. While the pathophysiology of tinnitus is poorly understood, there is currently a strong body of evidence to suggest that an underlying ... -
The Effects of Pharmacological Preconditioning with GYKI-52466 and Domoic Acid on LTP and LTD Induction in the Rat Hippocampus
Many neurodegenerative diseases are associated with severe memory loss and cognitive impairment, highlighting a critical demand for the development of neuroprotectants and nootropics. It has been shown that certain compounds ...