Browsing Pharmacology and Toxicology by Title
Now showing items 52-70 of 70
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Targeting the Anaplastic Lymphoma Kinase (ALK) and the Insulin-like Growth Factor Receptor 1 (IGF1R) in crizotinib resistant lung cancer cells
Non-small lung cancer (NSCLC) accounts for approximately 85% of all lung cancer-related deaths worldwide. Historically, platinum-based chemotherapy regimens have been the first-line treatment for advanced NSCLC, however ... -
Temporal Effects of Acoustic Trauma-Induced Tinnitus on the Extracellular Levels of Amino Acids in the Inferior Colliculus of Rats.
Tinnitus is often defined as the perception of sound in the absence of a physical or an external acoustic source. While the exact underlying causes of tinnitus remain poorly understood, there is growing evidence to suggest ... -
The cannabinoid CB2 receptor as a target for the treatment of neuropathic pain
Cannabinoids are cannabis-like drugs that are moderately efficacious in the treatment of some types of chronic pain, including pain of a neuropathic origin. Limiting their therapeutic application, however, are adverse ... -
The Cytotoxic Mechanism of RL112 in Ovarian Cancer Cells
Background: Ovarian cancer is the most lethal gynecological malignancy among women, and there is limited treatment. The search for effective therapies for ovarian cancer has led to the emergence of natural compounds such ... -
The Cytotoxicity and Action of Curcumin Derivatives against Fn14+ Triple Negative Breast Cancer through repression of NF-κB p65
Triple negative breast cancer (TNBC) is an aggressive subtype of the disease which lacks options for targeted systemic therapies due to a lack of actionable clinical targets. Molecular analysis has revealed that Fn14, a ... -
The effect of anxiolytic and anxiogenic drugs on spatial memory and anxiety-related behaviours in bilateral vestibular deafferented rats
Vestibular dysfunction in humans is associated with a high rate of anxiety and depressive disorders. Although this may first appear to be due to the burden of living with a balance disorder, there is reason to think that ... -
The Effect of Photoactivation on the Mechanism of Action of tDodSNO
Since the discovery and identification of nitric oxide (NO) in vivo more than 30 years ago, a wealth of knowledge has been collected regarding its biological action. More recently, NO has been shown to be a valuable ... -
The effect of vestibular lesions on the hippocampal cholinergic system
Bilateral vestibular loss (BVL) produces profound behavioural changes, some of which do not appear to be directly associated with the acute loss of vestibular information, such as hyperlocomotion and spatial memory ... -
The Effects of Direct Infusion of L-Baclofen or CGP7930 into the Dorsal Cochlear Nucleus on the Development of Noise-Induced Tinnitus in Rats
Tinnitus is a phantom auditory sensation that many experience at some point in their lives. Generally, the sensation is transient; however, an increasing number of people suffer from chronic tinnitus. Treatment options for ... -
The Effects Of Early L-Baclofen Administration On The Development Of Tinnitus Induced By Acoustic Trauma, And GABAB-R2 Expression, In Rats
Tinnitus is an illusory auditory sensation which often manifests as ‘ringing of the ears’. While the pathophysiology of tinnitus is poorly understood, there is currently a strong body of evidence to suggest that an underlying ... -
The Effects of Pharmacological Preconditioning with GYKI-52466 and Domoic Acid on LTP and LTD Induction in the Rat Hippocampus
Many neurodegenerative diseases are associated with severe memory loss and cognitive impairment, highlighting a critical demand for the development of neuroprotectants and nootropics. It has been shown that certain compounds ... -
The Impact of Renal Denervation on Structural Changes of Diabetic Nephropathy
Chronic bilateral renal denervation has been shown in clinical and experimental studies to reduce systemic blood pressure in resistant hypertension, along with protective effects on the kidney. However, the role of bilateral ... -
The Mechanisms of Neuroprotection by Melatonin in Cerebral Ischaemia Reperfusion
Stroke is a major cause of death and the highest cause of morbidity worldwide. In NZ, the elderly and Maori and Pacific Island ethnicities are most affected. With failure of many neuroprotectant agents, current clinical ... -
The Oxidative Modifications to Cancer Cells Induced by Three Redox-Active Drugs: Auranofin, PEITC and TDSNO
Redox homeostasis is of critical importance for normal cellular functions. The intracellular environment is maintained in a reduced state, upon which, reactive oxygen (ROS) and nitrogen (RNS) species oxidise cellular ... -
The Treatment of Neuropathic Pain with Cannabinoid Based Nanotechnology
The current treatment strategies for neuropathic pain are only partially effective at best. There is a drive to find more effective treatments for chronic forms of pain such as neuropathic pain. Cannabinoids are drugs that ... -
The use of combination tyrosine kinase inhibitors for the treatment of glioblastoma multiforme
Glioblastoma is the most common primary brain tumor which has a median survival of only 14.6 months. The central nervous system localization, heterogeneity of the cells and resistance to treatment constitute a significant ... -
Therapeutic Approaches in the Attenuation of Seizure-Induced Cardiomyopathy
Single subcutaneous administration of Kainic acid (KA) in the rat produces significant levels of seizure activity, including head tremors, salivation and tonic-clonic convulsions. Using electrophysiological quantitative ... -
Using Raloxifene and the Curcumin Derivative, RL91, for the Treatment of Castrate Resistant Prostate Cancer
Prostate cancer is the second most diagnosed cancer worldwide and accounts for 15% of all cancer in men. Localised prostate cancer, contained within the capsule of the prostate gland, is effectively treated with surgery, ... -
Vestibular Contributions to Spatial Memory and Hippocampal Function.
In addition to the deficits in the vestibulo-ocular and vestibulo-spinal reflexes that occur following vestibular dysfunction, vestibular loss may also cause cognitive disorders, especially spatial memory deficits, some ...