Physiology
The Department of Physiology at the University of Otago is the largest Department of Physiology in New Zealand. Established in 1905, the Otago Department of Physiology celebrated its 100th anniversary mid-2005. Over the years we have made major contributions to undergraduate science, physical education, medical, dental, pharmacy and physiotherapy education and we are one of the larger departments in the University. We have contributed markedly to biomedical research both nationally and internationally and have trained many postgraduates, a number of whom have attained high international reputation for their research.
Recent Deposits
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Regulation of DEPTOR Ubiquitination by Uric Acid in the Pancreatic β-Cell
As rates of non-communicable disease such as diabetes mellitus raise the questions regarding how these diseases arise becomes more pertinent. One of the major causes of these types of disease is the effects of the modern ... -
The forgotten arm of the fight-flight response: α-adrenergic control of the diabetic heart and interactions with Calmodulin Kinase 2
In Type 2 Diabetes Mellitus (T2DM) chronic metabolic stress and associated hemodynamic dysregulation result in a two-fold increase in cardiovascular disease (CVD) risk, making CVD a leading cause of death for T2DM patients ... -
Regulation of cardiac ryanodine receptor 2 by protein kinase CK2
The cardiac muscle ryanodine receptor (RyR2) is an intracellular Ca2+ channel responsible for the release of Ca2+ during excitation-contraction coupling. It is also implicated in pathological store-overload-induced Ca2+ ... -
Arterial Hypertension. Consume Carbon Monoxide?
Epithelial sodium channels (ENaC) are generally responsible for the passive movement of sodium ions through the apical cell membrane of salt absorbing epithelia. Canonical ENaC is composed of three homologous subunits, ... -
Characterisation of Arcuate Nucleus Projections to the Paraventricular Nucleus of Thalamus
The metabolic state (fed or hungry) has been shown to influence varying responses to food-associated cues. Recent studies reveal that the paraventricular nucleus of the thalamus (PVT) may play a critical role as it receives ... -
The α-Adrenergic System and CaMKII in Diabetic Heart Disease
The relationship between diabetes mellitus and heart disease is widely documented, with heart disease being the main cause of mortality in diabetic patients. Diabetes impairs the autonomic nervous system, leading to an ... -
The Role of α-ENaC and δ-ENaC in Breast Cancer Cell Migration
Breast cancer is an important disease worldwide, primarily affecting women, and is the most common and deadliest form of female cancer. This is reflected in New Zealand’s population as breast cancer has high incidence and ... -
The role of O-GlcNAcylation in regulating the function and structure of cardiac ryanodine receptors
Diabetes mellitus is projected to be the leading cause of death worldwide by the year 2030 and has been linked to many cardiovascular disorders, which together are known as, diabetic heart diseases (DHDs). DHDs include ... -
Investigating the mechanisms driving circadian and sex differences in the stress axis
The stress response allows the body to adapt to an ever-changing environment. Stress results in the activation of corticotrophin releasing hormone (CRH) neurons in the paraventricular nucleus (PVN) of the hypothalamus. ... -
Is sarcopenia a neurodegenerative disease?
Sarcopenia is a major contributor to the loss of independence and deteriorating quality of life in elderly individuals. It is marked by declining skeletal muscle mass and strength beyond the age of 65. Sarcopenia places ... -
Toll like receptor signalling in human colonic organoids
Three-dimensional primary cultures of colonic epithelium, or colonic organoids, are thought to be a suitable culture system to investigate the properties of human intestinal epithelium and its interaction with commensal ... -
Regulation of Corticotropin-Releasing Hormone Neuron Activity by Noradrenergic Stress Signals
The stress response is crucial for allowing adaptation to an ever-changing external environment. The neuroendocrine stress response is controlled by corticotropin-releasing hormone (CRH) neurons located within the ... -
Characterising the role of Vascular ENaC for Blood Pressure Regulation
Hypertension is characterised by extracellular fluid volume expansion and increased vascular tone. The epithelial sodium channel (ENaC) in the kidney has a central role in maintenance of extracellular fluid volume. In the ... -
Impact of Dietary Fatty Acids on Neuronal and Metabolic Health
In the past decades, the worldwide prevalence of obesity has nearly trebled. This trend is mainly caused by the permanent availability of food, the consumption of a Western-style diet, and the sedentary lifestyle of our ... -
Ghrelin and peripheral artery disease
Peripheral artery disease (PAD) is the most common cardiovascular disease associated with type 2 diabetes mellitus (T2DM). PAD is characterised by the narrowing or occlusion of systemic arteries impeding blood supply to ... -
Elucidating the effect of prenatal androgen excess on male reproductive function
The in utero nutritional and hormonal environment is critical in shaping the developing male and female reproductive systems. Elevated in utero androgen exposure has been correlated with the manifestation of abnormal ... -
Endosomal SNX Proteins are Required for Recycling of the Epithelial Sodium Channel.
The epithelial sodium channel (ENaC) facilitates Na+ absorption of polarised epithelia and is required for regulation of salt and water homeostasis. ENaC’s apical membrane population is strictly controlled, and loss of ... -
The pathophysiological role of microRNAs in diabtic cardiac stem cells
Cardiac stem cells (CSCs) have been implicated as the most suitable source of stem cells in regenerating the diseased heart. However, diabetes is known to cause a progressive loss in the functional efficacy of CSCs. MicroRNAs ... -
Human epicardial adipose tissue acutely increases atrial fibrillation
Epicardial adipose tissue (EAT) is a fat layer that directly contacts the atrial myocardium. Increased EAT mass has emerged as a new risk factor for developing the most common type of irregular heart rhythm, atrial ... -
The Stress and Strain of Triathlon Racing in Different Thermal Environments
Athletic endurance competitions in hot environments have become more relevant in professional sports. The inception for this thesis was to understand why a group of elite endurance triathletes repeatedly failed to perform ...