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Electrophysiological Characteristics of Kisspeptin Neurons in the Hypothalamus of the Mouse
The gonadotropin-releasing hormone (GnRH) neurons are the principal neurons in a network within the hypothalamus that controls fertility in all mammals. GnRH neuron output is influenced by a wide range of neurotransmitters. ...
A novel genetically encoded voltage indicator for studying motor cortical circuitry
The primary motor cortex (M1) consists of layers that are occupied by distinctive excitatory pyramidal neuron and inhibitory interneuron populations. Neurons within each layer receive inputs from numerous cortical and ...
Altered chronotropic regulation but normal cardiac sympathetic nerve activity in type 2 diabetic rat model
Autonomic control of cardiac function is impaired in diabetes mellitus, contributing to heart disease and premature death. Specifically, global elevated sympathetic nerve activity (SNA) coupled with dysregulated post-receptor ...
Effects of Tetraplegia and Passive Heat Stress on Systemic and Cerebral Vascular Function at Rest and during Orthostasis.
Spinal cord injury (SCI) is a debilitating disorder, causing cardiovascular dysfunction at rest and during orthostasis [as simulated by lower-body negative pressure (LBNP)], which differs with the level, completeness, and ...
Restorative effect of estrogen on basal forebrain cholinergic neurons
The basal forebrain cholinergic (BFC) system is one of the most important neurotransmitter systems in the brain. It has received much attention in the past two decades, primarily for its role in learning, memory, attention ...
Functional impact of a novel migraine mutation in the CaV2.1 channel
The neuronal voltage gated Ca2+ channel CaV2.1, regulates neurotransmitter release. Recently, the E1015K polymorphism was identified in the SNARE interaction synprint site of CaV2.1 in migraine patients. In this study, we ...
The involvement of mGluR1 hyper-activation in the progression of cerebellar ataxia in SCA1 mice
Spinocerebellar ataxia type 1 (SCA1) is an incurable, autosomal dominant progressive neurodegenerative disorder characterised by ataxia, progressive motor deterioration and selective neuronal loss in the cerebellum. It ...
The degradation of KCa3.1 in FRT polarised epithelium
The intermediate conductance calcium activated potassium channel (KCa3.1) has a prominent role in numerous physiological functions, and has recently emerged as the main therapeutic target for many disorders and diseases ...
Exploring the physiological and functional differences between stem cells isolated from the human right atrium and left ventricle
Recent discovery of resident cardiac stem cells (CSCs), capable of cardiac lineage differentiation and paracrine mediated effects, suggest promise for cardiac tissue repair. The best site in the heart for obtaining CSCs ...
Comparing subpopulations of gonadotropin-releasing hormone (GnRH) neurons with viral mediated cell-filling
Gonadotropin-releasing hormone (GnRH) neurons are the central regulators of reproductive function in all mammals. The cell bodies of GnRH neurons are unique in that they are not confined to a discrete nucleus, but rather ...