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beta1- and beta2-adrenoceptor cardiovascular responsiveness in the type II Zucker Diabetic Fatty rat model
Sympathetic nervous system dysfunction is prevalent in diabetes. It is characterised by increased sympathetic nerve activity and elevated circulating catecholamine levels and altered β-adrenoceptor (β-AR) responsiveness. ...
Characterisation of HCO3- secretion in the small intestine of the brushtail possum, Trichosurus vulpecula
The Australian common brushtail possum, (Trichosurus vulpecula), is the most significant mammalian pest in New Zealand. The damage done by wild possums has a major impact on New Zealand flora and fauna through destruction ...
Anticonvulsant actions of antidepressants in a novel model of acute seizures in vitro
Epilepsy affects around 1 % of the population, and up to a third of patients are resistant to antiepileptic drugs (AEDs). Epilepsy is defined as an enduring predisposition of the brain to generate seizures, and the disorder ...
The role of lipopolysaccharide/Toll-like Receptor 4 signalling pathway during liver regeneration after partial hepatectomy in mice
The process of liver regeneration after partial hepatectomy is very complex and is associated with signalling cascades involving initiation signals, transcription factors, cytokines, growth factors, tissue remodelling and ...
Interaction between COMMD family proteins and the epithelial sodium channel
The epithelial sodium channel (ENaC) is located at the apical membrane of many epithelial cells throughout the body and mediates Na+ influx into epithelial cells. Classical ENaC is made up of three similar subunits, α, β ...
Cellular Mechanisms of Prolactin Regulation of Oxytocin Neurons in Reproduction
The hormone oxytocin is secreted from nerve terminals of oxytocin magnocellular cells (MNCs) in the posterior pituitary gland and is important in the timing of birth and is essential for milk secretion. Another reproductive ...
Dynamic response characteristics of calf muscle blood flow and vascular conductance during exercise and recovery
Abstract
The primary aim of this thesis was to describe the dynamic response characteristics of leg blood flow (LBF) and leg vascular conductance (LVC) during exercise and recovery, and to investigate the influence of ...
Restorative effect of estrogen on basal forebrain cholinergic neurons
The basal forebrain cholinergic (BFC) system is one of the most important neurotransmitter systems in the brain. It has received much attention in the past two decades, primarily for its role in learning, memory, attention ...
Effects of Tetraplegia and Passive Heat Stress on Systemic and Cerebral Vascular Function at Rest and during Orthostasis.
Spinal cord injury (SCI) is a debilitating disorder, causing cardiovascular dysfunction at rest and during orthostasis [as simulated by lower-body negative pressure (LBNP)], which differs with the level, completeness, and ...
Establishing an in vitro condition to study the functional relevance of cardiac-specific micrornas
Ischemic heart disease is a leading cause of mortality among individuals with Type 2 diabetes. Since their discovery in 1993, microRNAs (miRs) are described to be short non-coding RNAs that post-transcriptionally regulate ...