Surgery - Christchurch
Recent Deposits
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Complication profiling and Evolution of pelvic exenteration surgery performed in high volume tertiary referral centres over thirty years
Objective: To examine the changes in exenterative surgery over three decades analysing oncological outcomes and whether changes in surgical approach have led to improved patient outcomes Background: Advances in surgical ... -
Bacterial Lipopolysaccharide and Immune Activation in Colorectal Cancer
Colorectal cancer (CRC), is the second deadliest cancer in New Zealand. At early stages tumours can be treated with surgery or a combination of surgery and chemotherapy. However, once the cancer has metastasized, treatment ... -
E-cadherin and APC in early-onset colorectal cancer
Colorectal cancer (CRC) is a considerable health burden being the second highest cause of cancer deaths globally. While overall cases of CRC have been declining worldwide, there has been an increase in the incidence of the ... -
The Impact of Frailty on Outcomes Following Major Colorectal Surgery
With an ageing population, an increasing number of elderly patients are presenting for surgical intervention. Perioperative risk assessment in this population is difficult and commonly used tools often fail to accurately ... -
Predicting the Response to Radiotherapy for Rectal Cancer
Aim To investigate predictors of pathological response to radiotherapy for rectal cancer by reviewing the evidence, exploring clinicopathological predictors in a local cohort and investigating markers of oxidative stress ... -
Clinical guideline use and compliance: examining variation from the clinical pathway
Introduction Clinical guidelines are developed with the aim of optimising patient care and have been shown to improve both clinical outcomes and the care process. ‘Hospital HealthPathways’ are guidelines published for use ... -
External Validation of Consensus Molecular Subtyping of Colorectal Adenocarcinoma
Background: Colorectal cancer (CRC) is the second most diagnosed cancer in New Zealand, and New Zealand has amongst the highest rates per capita of CRC in the world. CRC is a highly heterogeneous disease with varying ... -
The Canterbury Ileal Pouch-Anal Anastomosis Study
Background and aim: Inflammatory bowel disease (IBD) is an increasingly prevalent chronic disease, frequently with an early age of onset and no cure. It is important to ascertain which treatments are effective and ... -
Aspirin’s role in preventing E-cadherin cleavage by the carcinogenic Bacteroides fragilis toxin
Carriage of enterotoxigenic Bacteroides fragilis (ETBF) in the colonic mucosa is associated with increased risk of pre-cancerous lesions. Antibiotics will not selectively eradicate these bacteria, but toxin-mediated host ... -
What Factors Are Associated With Guideline Use and Compliance?
Introduction Clinical guidelines are recommendations targeted at medical professionals which aim to optimise patient care. When successfully implemented, clinical guidelines have been shown to improve processes of care ... -
Influence of Risk Factors on Incidence, Management, Recurrence, and Follow-up of Acute Diverticulitis.
Acute Diverticulitis is a significant problem, accounting for up to one third of acute surgical admissions. Despite significant and rapid advances in medical knowledge, it remains a poorly understood disease. Practice ... -
Design of cell-instructive photo-polymerisable hydrogels towards functional tissue engineered cartilage
In recent years, scaffold-based strategies adopting hydrogels for cartilage regeneration have received significant attention, offering manipulation of chemical, biological and physical parameters to match design criteria. ... -
Integration and automation of a micro-tissue and microsphere based tissue engineering system and its application in cartilage regeneration and cancer models
Bottom-up biofabrication approaches for fabricating engineered tissue constructs are emerging strategies in tissue engineering. Few technologies have been developed that are capable of assembling tissue units into 3D Plotted ... -
Development and Validation of Medical Decision Tools in Detection and Treatment of Abdominal Aortic Aneurysm
Abdominal aortic aneurysm (AAA) is a permanent dilatation of the infrarenal segment of the abdominal aorta which can be fatal if the aneurysm ruptures. Ruptured AAA is the second leading cause of global surgical mortality, ... -
The effect of polymeric formula on enterocyte differentiation
Exclusive Enteral Nutrition (EEN) is commonly used in the management of Crohn's disease (CD). Polymeric formulae (PF), comprising whole proteins along with the daily requirements of vitamins and minerals, are commonly used ... -
The Impact of Obesity on Outcomes Following Major Colorectal Surgery
Introduction Obesity is a major health problem in western society with rapidly increasing prevalence in most countries. The healthcare burden of obesity is far reaching but many of the consequences are yet to be fully ... -
The effect of Helicobacter pylori on cellular iron homeostasis
Iron deficiency anaemia (IDA) is a serious health problem worldwide, particularly in developing countries. Infection with the gastric pathogen Helicobacter pylori is more prevalent in developing countries. Additionally, ... -
Inner Ear Effects of Middle Ear Surgery
Introduction Hearing loss following middle ear surgery is an important issue because it is common, is detrimental to patients, and may be preventable. Patients are often told the risk of inner ear hearing loss following ...