Pathology and Molecular Medicine

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Recent Deposits

The role of cross-presenting dendritic cells in tumour progression and immunotherapy

Gilfillan, Connie Bep (Thesis, Doctor of Philosophy, 2017)

The recognition and eradication of cancer cells by the immune system is reliant on dendritic cells (DCs). DCs are professional antigen-presenting cells (APCs) that are integral for the initiation of an adaptive immune ...
Cytotoxic T cell-mediated immunotherapy of allergic airway inflammation

Daniels, Naomi (Thesis, Doctor of Philosophy, 2016)

The worldwide incidence of atopic disease, including asthma, has increased dramatically over the last few decades. In New Zealand, asthma affects at least one in four children and one in six adults, a prevalence among the ...
Role of TSLP in Dendritic Cell Programming during Allergic Responses

Ochiai, Sotaro (Thesis, Doctor of Philosophy, 2016)

Allergic diseases such as atopic dermatitis (AD), asthma and allergic rhinitis are among the most common chronic illnesses around the world. Although they cause significant discomfort to those affected, effective treatments ...
Role of IL-25 in the maintenance of intestinal homeostasis and host-microbial interactions

Plunkett, Catherine Heather (Thesis, Doctor of Philosophy, 2016)

Within the gastrointestinal (GI) tract a rich, diverse microbiota exists, which provide a number of benefits to the host including nutrient acquisition and immune maturation. However, strict immunological control is required ...
Serum biomarkers and paracetamol during post-chemotherapy infections

Bowden, Emily Ellen (Thesis, Bachelor of Biomedical Sciences with Honours, 2015)

Background: Febrile neutropenia (FN) is a common complication of cancer chemotherapy defined as fever with neutropenia below 1.0 x109 /L. Prompt antibiotic treatment is life-saving. Antipyretics (e.g. paracetamol) are ...
Cancer Stem Cells in Squamous Cell Carcinoma of the Oral Tongue

Baillie, Ranui Francesca (Thesis, Bachelor of Medical Science with Honours, 2015)

Background: Given the discovery of cancer stem cells (CSCs) within haematological and solid tumours and the expression of primitive markers by infantile haemangioma, it was hypothesised that a CSC population would also be ...
Liver Molecular Mechanisms Involved in Type 2 Diabetes: An Investigation Using Roux-en Y Gastric Bypass as a Human Model of Diabetes Remission

Besic, Vinko (Thesis, Doctor of Philosophy, 2014)

Type 2 diabetes mellitus is a chronic disease characterised by progressive insulin resistance and loss of β-cell function. An incomplete understanding of its pathogenesis is hindering the effective treatment of this disease. ...
The protective CD4⁺ memory T cell response to tuberculosis

Ancelet, Lindsay Rae (Thesis, Doctor of Philosophy, 2013)

Infection with Mycobacterium tuberculosis (Mtb), the pathogen responsible for tuberculosis (TB), results in 1.4 million deaths annually. The escalating rate of active TB, due to co-infection with HIV and emergence of ...
Invariant Natural Killer T Cells in Chronic Lymphocytic Leukaemia

Weinkove, Robert (Thesis, Doctor of Philosophy, 2012)

Invariant natural killer T (iNKT) cells recognise glycolipid antigens, such as the synthetic ligand alpha galactosylceramide (a-GalCer), in the context of CD1d. Upon recognition of a-GalCer on CD1d, iNKT cells become ...
Remission of Type 2 Diabetes Mellitus following Bariatric Surgery: An investigation into relevant changes in gastrointestinal physiology

Foo, Jonathan (Thesis, Doctor of Philosophy, 2012)

A rapid remission of type 2 diabetes mellitus occurs after gastric bypass surgery in the morbidly obese however, a unifying explanation for the associated normalisation of glucose and insulin parameters of diabetes of this ...
Proteomic Identification and Immunological Validation of Protein Biomarkers for Early Detection and Prognosis of Colorectal Cancer

Shi, Hongjun (Thesis, Doctor of Philosophy, 2012)

Colorectal cancer (CRC) is an important public health problem both internationally and in New Zealand. Currently available systems for early cancer detection (Faecal Occult Blood Test) and prediction of prognosis (pathological ...
An observational study investigating the objective and subjective impact of a structured gynaecology service for women who have undergone allogeneic haematopoietic stem cell transplant.

Wood, Catherine Elizabeth (Thesis, Master of Health Sciences, 2012)

Hypothesis: The hypothesis for this study is that the provision of consultative gynaecological care and the delivery of gynaecological information to women undergoing allogeneic stem cell transplant will mean a better ...
The Responses of Dental Plaque Microcosms to Experimental Environmental Changes

Wall-Manning, Glenn Michael (Thesis, Doctor of Philosophy, 2012)

The overall objective of this study was to increase our understanding of the compositional changes in dental plaque biofilms during and after the application of antimicrobial agents. Dental plaque contains thousands of ...
Role and dynamics of yeast species in oral biofilms

Weerasekera, Manjula Manoji (Thesis, Doctor of Philosophy, 2011)

Oral biofilms are complex microbial ecosystems. In humans there are more than 900 oral microbial species, most with unknown properties or roles in disease. Candida albicans has cariogenic properties but its role in dental ...