Surgery and Anaesthesia: Recently added
Now showing items 1-19 of 19
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Extracellular vesicle microRNA as liquid biopsy biomarkers in early stage colorectal cancer patients
New Zealand has one of the highest rates of colorectal cancer (CRC) in the world. Current strategies to diagnose CRC, including population level stool-based screening, are flawed due to poor sensitivity in early disease ... -
ADSC-EVs and Macrophage Polarization in Fat Grafting for Breast Reconstruction
Breast Cancer is the most commonly diagnosed cancer among women in New Zealand, with an estimated 3000 women diagnosed in New Zealand every year. The most common form of treatment is surgery, and following treatment, the ... -
High Altitude Medicine: Understanding the Mechanism of Acute Mountain Sickness
The present study was undertaken to determine the integrative physiology behind acute mountain sickness (AMS) susceptibility. We compared the respiratory, cardiovascular, renal and cerebrovascular responses to acute ... -
Improving the assessment process for patients presenting with acute (non-traumatic) abdominal pain to the general surgery department.
Background Abdominal pain is a very common but also challenging presentation to general surgery. A number of implementations have been introduced to improve the diagnostic process. These include: ED 4-6 hour targets, acute ... -
Plasma microRNA biomarkers in rectal cancer patients undergoing neoadjuvant therapy
Colorectal cancer (CRC) is the second most common cause of cancer related death worldwide with an expected 1.8 million new cases this year (1). CRC claims approximately 1200 New Zealand lives per year and rectal cancer ... -
Biomarkers and Lymph Node Morphology in Early-stage Colon Cancer
New Zealand has one of the highest rates of colorectal cancer (CRC) in the world, resulting in approximately 1200 deaths per year. Optimising the use of adjuvant chemotherapy is one key area to reduce CRC-related mortalities. ... -
Antiplatelet and anticoagulant therapy in patients with acute coronary syndromes and atrial fibrillation
Dual antiplatelet therapy (DAPT), consisting of aspirin and a P2Y12 receptor antagonist, is the standard of care following an acute coronary syndrome (ACS) presentation, and oral anticoagulation (OAC) is standard of care ... -
Assessment of Baroreflex Sensitivity and its Interaction with Cerebral Pressure-flow Dynamics
Abstract Assessment of baroreflex sensitivity (BRS) is used extensively in research to study neural regulation of cardiovascular function, and BRS estimation offers a potential diagnostic and prognostic utility in ... -
Interindividual relationships between baroreflex sensitivity and cerebral autoregulation in healthy humans
Maintenance of adequate cerebral perfusion during normal physiological challenges requires integration between cerebral blood flow (CBF) and systemic blood pressure (BP) control mechanisms. Previous studies have shown that ... -
Ventricular Fibrillation waveform characteristics
This thesis has explored the information content of the ventricular fibrillation (VF) waveforms recorded as either a surface electrocardiogram (ECG) or an intracardiac electrogram (EGM). Ventricular fibrillation is lethal ... -
ECG-based Risk Stratification of Ventricular Arrhythmia in Implantable Cardioverter Defibrillator (ICD) Patients
Aim: Implantable cardioverter defibrillators (ICDs) are life-saving devices invented in the 20th century that are now the standard of care for patients at high risk of ventricular arrhythmia, largely defined by either ... -
Strain and Pacing Study: The Effect of Pacing on the Mechanics of Cardiac Strain
Aims: Our aim was to find a strain-based echocardiographic measurement that could detect a difference in the LV function cardiac mechanics between paced and intrinsic conduction. The study assessed strain-based measurements ... -
Extended Care Paramedic clinical guideline compliance, does it have potential for harm?
Background Extended Care Paramedic (ECP) practice is aimed at managing more patients at home or in the community under a delegated scope of practice applying pre-determined clinical guidelines. These clinical guidelines ... -
Effect of Toll-like Receptor agonists on platelet activation in Acute Coronary Syndromes
Introduction: Platelets express functional Toll-like receptors (TLRs), and numerous studies have found that certain TLR agonists and bacteria are capable of inducing thrombotic and inflammatory responses from isolated ... -
Workplace First Aid in New Zealand
In New Zealand the Department of Labour provides guidance on the provision of first-aid equipment, facilities and training to meet the requirements of the Health and Safety in Employment Act 1992, and Regulations 1995. ... -
The Application of Spectral Analysis of the Surface Electrocardiography Prior to Direct Current Cardioversion in Patients with Persistent Atrial Fibrillation
Aims: The decision of treatment strategy made for atrial fibrillation (AF) patients is ideally based on individual atrial remodeling. Electrical remodeling is believed to influence the outcome of direct current cardioversion ... -
Interaction between cardiac and ventilatory timing during sleep
Cardioventilatory coupling is the temporal alignment between inspiratory onset and preceding heart beat, and is a determinant of ventilatory timing. Although investigated in anaesthetised and resting individuals, as well ... -
Cardiorespiratory Rhythmicities in Humans
Although the basic determinants of cardiovascular and respiratory regulation are well described, the complex integration of these processes on a beat-to-beat, breath-to-breath basis is less widely appreciated. Cardiorespiratory ... -
The Cost Effectiveness of Implantable Cardioverter Defibrillator Therapy in New Zealand
The Implanted Cardioverter Defibrillator (ICD) has emerged as one of the strongest therapeutic options for patients at high risk of SCD [65-67]. Despite this its high cost, in relation to other therapies, has made its use ...