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Pathology Department
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Recent Deposits
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(Thesis, Bachelor of Biomedical Sciences with Honours, 2016)Triple-negative breast cancer (TNBC) is an aggressive disease subtype with no current targeted systemic therapies due to a lack of actionable molecular targets. Efforts to identify therapeutic targets in TNBC have revealed ...
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(Thesis, Doctor of Philosophy, 2016)The tumour suppressor gene p53 is the master sensor and regulator of the response to cell stress. Upon DNA damage, p53 can induce various outcomes including apoptosis, cell cycle arrest, senescence, and DNA repair in order ...
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(Thesis, Doctor of Philosophy, 2016)BACKGROUND The best APC for tumour immunotherapy is yet to be defined. The dendritic cell (DC) is well established as the key professional antigen-presenting cell (APC) for priming naïve T cells against tumours and for ... -
(Thesis, Master of Medical Science, 2016)Acute lymphoblastic leukaemia (ALL) is a malignant proliferation of immature lymphocytes, mainly occurring in childhood. The pathogenesis of the disease is characterised by multiple molecular abnormalities, including ... -
(Thesis, Master of Science, 2016)The tumour suppressor protein p53 is one of the most well-known and well-studied proteins, with a vast amount of research dedicated to understand its role in tumour formation. Despite this, little is known about its function ...
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(Thesis, Doctor of Philosophy, 2016)The inheritance of epigenetic signals involves DNA methylation. DNA methylation patterns are inherited through cell generations by the action of DNA methyltransferases (DNMTs). During DNA replication DNMTs recognise ...
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(Thesis, Doctor of Philosophy, 2016)Runx1 is crucial for blood cell development and is one of the genes most frequently translocated or mutated in leukaemia, thereby contributing to disease pathogenesis. Runx1 is transcribed from two promoters, P1 and P2, ...
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Effect of cystathionine-gamma-lyase gene silencing with siRNA on inflammation in acute pancreatitis (Thesis, Doctor of Philosophy, 2016)Hydrogen sulfide (H2S) is an endogenous inflammatory mediator produced by the activity of cystathionine γ–lyase (CSE) in mammals. Macrophages are a key element of the immune system and play a crucial role in inflammation. ... -
(Thesis, Doctor of Philosophy, 2016)Recently, new discoveries in the field of cancer immunology have been able to increase the strength of immune responses against tumors. For example, monoclonal antibodies such as Ipilimumab and Nivolumab are able to ... -
(Thesis, Bachelor of Biomedical Sciences with Honours, 2015)Gout was historically known as the king of diseases and disease of kings, reserved for those of wealthy, extravagant lifestyles. Far from being resigned to history books, gout is on the rise worldwide and in New Zealand – ... -
(Thesis, Bachelor of Biomedical Sciences with Honours, 2015)p53 gene is the most commonly mutated gene in cancer, and in many malignancies a loss of p53 promotes cancer progression. However recent evidence has shown that missense mutations in p53, particularly those that lead to ...
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(Thesis, Master of Science, 2015)Detection of nucleotide sequence variations in patients of some diseases, provides strong evidence as to which genes and regulatory elements play a critical role in vivo. Acute Myeloid Leukaemia (AML) is a fast acting blood ... -
(Thesis, Doctor of Philosophy, 2015)Two-thirds of human breast carcinomas test positive for oestrogen receptor α (ERα), which predominantly mediates oestrogenic actions in the normal breast as well in breast tumour cells. Treatment of hormone-sensitive tumours ... -
(Thesis, Doctor of Philosophy, 2015)The placenta is a crucial element of human life. It sustains and enables the development from a small group of cells to a whole organism. The placenta is a unique organ that fulfils multiple roles, from delivery of oxygen ... -
(Thesis, Doctor of Philosophy, 2015)Adoptive cell therapy (ACT) with tumour-reactive T cells has been shown to be one of the most effective cancer treatments. However, there are many consensus questions that need to be answered so that ACT can deliver a more ... -
(Thesis, Doctor of Philosophy, 2015)Major psychiatric illnesses including bipolar disorder and schizophrenia can be highly debilitating and collectively have a lifetime incidence of approximately 1% in the general population. Twin and adoption studies have ... -
(Thesis, Doctor of Medicine, 1964)The main aim of this thesis is to study from a clinicopathological aspect the pattern of development and the nature of lesions, particularly renal ones, in NZB/BL X NZW hybrid mice. Groups of these mice were assessed ... -
(Thesis, Doctor of Philosophy, 2015)Oxidative stress, an imbalance in the cellular redox systems, could be a major influence on organism development. To investigate this possibility I carried out basic research into the antioxidant systems in the zebrafish ... -
(Thesis, Master of Medical Laboratory Science, 2015)Greater understanding of the pathological mechanisms underlying recurrent driver mutations is revolutionising the clinical management of melanoma. However given the association between UV radiation and UV-associated DNA ...
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(Thesis, Bachelor of Biomedical Sciences with Honours, 2014)Cervical cancer in females is a worldwide health issue. High risk subtype of human papilloma viruses (HPV) are involved as a major risk factor. HPV oncogenes, E7 and E6 which are over-expressed in the host cells and promote ...
