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Genetics in the Pathogenesis and Treatment of Panic and Anxiety
Mental disorders form a broad category of disease that may manifest as emotional or behavioural changes. These disorders are common globally and account for a significant amount of morbidity. The most frequently occurring ...
Methods for Exploiting the Childhood Acute Lymphoblastic Leukaemia DNA Methylation Profile to Detect a Novel Population of Fetal Lymphocytes
The incidence of childhood acute lymphoblastic leukaemia (B-ALL) has increased since 1950s worldwide. The disease affects young children and it has physical and psychosocial impacts on children and their families. Different ...
Radical Development: the developmental consequences of oxidative stress in zebrafish
Oxidative stress, an imbalance in the cellular redox systems, could be a major influence on organism development. To investigate this possibility I carried out basic research into the antioxidant systems in the zebrafish ...
Enhancing Adoptive Cell Transfer for the Treatment of Cancer
Cancer is currently the leading cause of death in New Zealand, accounting for 30% of all deaths in 2010. Due to factors such as an ageing population and poor lifestyle choices, the incidence and mortality of this disease ...
Development of a new microparticle vaccine adjuvant with the ability to deliver peptides and siRNAs to Dendritic Cells in order to boost the immune response
Recently, new discoveries in the field of cancer immunology have been able to increase the strength of immune responses against tumors. For example, monoclonal antibodies such as Ipilimumab and Nivolumab are able to ...
Adoptive Cell Therapy using CD4 T Helper 1-like and CD8 Cytotoxic T Lymphocytes in a Mouse Model of Melanoma
Adoptive cell therapy (ACT) with tumour-reactive T cells has been shown to be one of the most effective cancer treatments. However, there are many consensus questions that need to be answered so that ACT can deliver a more ...
The natural history of autoimmune disorders in mice and its modification by therapy
The main aim of this thesis is to study from a clinicopathological aspect the pattern of development and the nature of lesions, particularly renal ones, in NZB/BL X NZW hybrid mice. Groups of these mice were assessed ...
DISC1 in Psychiatric Illness
Major psychiatric illnesses including bipolar disorder and schizophrenia can be highly debilitating and collectively have a lifetime incidence of approximately 1% in the general population. Twin and adoption studies have ...
Bioinformatic Approaches to Analysing RRBS Data in the Context of Pre-eclampsia
The placenta is a crucial element of human life. It sustains and enables the development from a small group of cells to a whole organism. The placenta is a unique organ that fulfils multiple roles, from delivery of oxygen ...
Epigenetics and Expression of SFRP1 and PPARG and Epigenetic Effects of Glucocorticoids in B-cell Acute Lymphoblastic Leukaemia
B-cell Acute Lymphoblastic Leukaemia (B-ALL), a cancer of immature B-lymphocytes, is the most common cancer in childhood. This cancer is characterised by widespread abnormalities of DNA methylation, when compared with ...