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Bioinformatic Approaches to Analysing RRBS Data in the Context of Pre-eclampsia
The placenta is a crucial element of human life. It sustains and enables the development from a small group of cells to a whole organism. The placenta is a unique organ that fulfils multiple roles, from delivery of oxygen ...
Gene Regulation by Drugs Used to Treat Mood Disorders
Mood disorders such as Major Depressive Disorder and Bipolar Disorder are devastating burdens upon sufferers, their families and society as a whole. Despite their high prevalence and socioeconomic impact, understanding the ...
Reduced Representation Bisulfite Sequencing of Human Neutrophils Reveals Widespread Inter-Individual Epigenetic Variation
Methylation of DNA molecules is a fundamental mechanism for regulating gene function that is prevalent in all vertebrates. Although, the role of DNA methylation is well recognised in the disease context, the knowledge of ...
Transcriptional regulation of the Runx1 gene
Runx1 is crucial for blood cell development and is one of the genes most frequently translocated or mutated in leukaemia, thereby contributing to disease pathogenesis. Runx1 is transcribed from two promoters, P1 and P2, ...
Chemically induced DNA hemimethylation and active demethylation
The inheritance of epigenetic signals involves DNA methylation. DNA methylation patterns are inherited through cell generations by the action of DNA methyltransferases (DNMTs). During DNA replication DNMTs recognise ...
Searching for a Functional Variant in a Non-Coding Genomic Region Associated with Serum Urate
Gout was historically known as the king of diseases and disease of kings, reserved for those of wealthy, extravagant lifestyles. Far from being resigned to history books, gout is on the rise worldwide and in New Zealand – ...
Investigating the function of cis-regulatory elements for Runx1
Detection of nucleotide sequence variations in patients of some diseases, provides strong evidence as to which genes and regulatory elements play a critical role in vivo. Acute Myeloid Leukaemia (AML) is a fast acting blood ...
Mutant p53 and pro-inflammatory gene expression in colorectal cancer cells
p53 gene is the most commonly mutated gene in cancer, and in many malignancies a loss of p53 promotes cancer progression. However recent evidence has shown that missense mutations in p53, particularly those that lead to ...
Oestrogen-dependent regulation of gene expression by cohesin in breast cancer
Two-thirds of human breast carcinomas test positive for oestrogen receptor α (ERα), which predominantly mediates oestrogenic actions in the normal breast as well in breast tumour cells. Treatment of hormone-sensitive tumours ...
Peripheral lobular necrosis in hepatitis
Foreword: In recent years knowledge of the clinical and pathological features of hepatitis has so increased that the disease has now become the subject of reviews (e.g: Sodeman 1946, Editorial, Ann. Int. Med. 1946, Dible ...